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Biological adhesive with tissue adhesion and growth promoting effect as well as preparation method and application of biological adhesive

A technology of bioadhesives and adherents, applied in the field of biomedicine, can solve problems that need to be improved, and achieve the effect of long shelf life

Pending Publication Date: 2019-03-01
武汉原生原代生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Therefore, existing bioadhesive products and preparation methods still need to be improved

Method used

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  • Biological adhesive with tissue adhesion and growth promoting effect as well as preparation method and application of biological adhesive
  • Biological adhesive with tissue adhesion and growth promoting effect as well as preparation method and application of biological adhesive
  • Biological adhesive with tissue adhesion and growth promoting effect as well as preparation method and application of biological adhesive

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1、40

[0067] Example 1, Preparation of tissue adhesion and growth bioadhesive with 40% water content

[0068] (1) Take 100ml of double-distilled water and pour it into a 500ml reaction vessel, and place the reaction vessel on a mechanical stirrer to keep it at 30 degrees Celsius;

[0069] (2) Tissue adhesions: slowly add 1 mass part of collagen and silk protein (mass ratio 1:1), 1 mass part of gelatin and matrigel (mass ratio 1:1), 1 mass part of shell Add polysaccharides, hyaluronic acid and chondroitin sulfate (mass ratio 1:1:1), 1-5 parts by mass of alginate, 1 part by mass of polyethylene glycol, and 1 part by mass of cell matrix into the reaction vessel, Carry out mechanical stirring, the stirring speed is 100r / min, and the stirring time is 30min;

[0070] (3) Tissue growth additives: Slowly add tissue growth additives with a mass percentage of 1% in sequence, and perform mechanical stirring at a stirring speed of 100r / min for a mixing time of 30min;

[0071] (4) Tissue pitui...

Embodiment 2、60

[0075] Example 2, Preparation of tissue adhesion and growth bioadhesive with 60% water content

[0076] (1) Take 200ml of double-distilled water and pour it into a 500ml reaction vessel, and place the reaction vessel on a mechanical stirrer to keep it at 37 degrees Celsius;

[0077] (2) Tissue adhesions: slowly add 8 parts by mass of collagen and silk protein (mass ratio 1:1), 4 parts by mass of gelatin and matrigel (mass ratio 1:1), and 4 parts by mass of shell Put polysaccharides, hyaluronic acid and chondroitin sulfate (mass ratio 1:1:1), 4 parts by mass of alginate, 4 parts by mass of polyethylene glycol, and 2 parts by mass of cell matrix into the reaction vessel for mechanical Stirring, stirring speed 120r / min, stirring time 20min;

[0078] (3) Tissue growth additives: Slowly add tissue growth additives with a mass percentage of 10% in sequence, and perform mechanical stirring at a stirring speed of 120r / min and a stirring time of 20min;

[0079] (4) Tissue pituitary e...

Embodiment 3、80

[0083] Example 3, Preparation of tissue adhesion and growth bioadhesive with 80% water content

[0084] (1) Take 300ml of double-distilled water and pour it into a 500ml reaction vessel, and place the reaction vessel on a mechanical stirrer to keep it at 55 degrees Celsius;

[0085](2) Tissue adhesions: Slowly add 20 parts by mass of collagen and silk protein (mass ratio 1:1), 10 parts by mass of gelatin and matrigel (mass ratio 1:1), 10 parts by mass of shell Polysaccharide, hyaluronic acid and chondroitin sulfate (mass ratio 1:1:1), 10 mass parts of alginate, 10 mass parts of polyethylene glycol, and 10 mass parts of cell matrix are put into the reaction vessel, and mechanically Stirring, stirring speed 150r / min, stirring time 10min;

[0086] (3) Tissue growth additives: Slowly add tissue growth additives with a mass percentage of 20% in sequence, and perform mechanical stirring at a stirring speed of 150r / min and a stirring time of 10min;

[0087] (4) Tissue pituitary ext...

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Abstract

The invention provides a biological adhesive with a tissue adhesion and growth promoting effect. The biological adhesive comprises a tissue adhesive, a tissue growth additive, a tissue hypophysis extract and a penetrating agent. The biological adhesive with the tissue adhesion and growth promoting effect has very good adhesion and growth promoting effect for tissue, can promote tissue to adhere totissue carriers such as PVC (polyvinyl chloride) on one hand and promote tissue adhered to carriers to grow on the other hand and has important application value in the biomedicine field.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular, the invention relates to a bioadhesive for promoting tissue adhesion and growth, its preparation method and application. Background technique [0002] Adhesives have the function of bonding, and can be divided into chemical adhesives and biological adhesives according to their material properties. Chemical adhesives include: cyanoacrylate adhesives; polyurethane adhesives; silicone adhesives, etc. Among them, cyanoacrylate adhesives are the earliest and most widely used chemical adhesives. Bioadhesives mainly include fibrin cement (FS). Fibrin adhesives are the earliest and most widely used biological adhesives. At present, bioadhesives are mainly used clinically, that is, medical bioadhesives, which are biomedical materials used to prevent tissue adhesion, stop bleeding, and prevent air and body fluid leakage during operations. Its main component is fibrin. Because chemical adhesive...

Claims

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Application Information

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IPC IPC(8): C12N5/077C12N5/071C12N5/09C12N5/0786
CPCC12N5/0645C12N5/0661C12N5/0671C12N5/0684C12N5/0688C12N5/0693C12N2500/80C12N2500/84C12N2533/80C12N2533/72C12N2533/50C12N2533/54C12N2533/70
Inventor 刘东旭
Owner 武汉原生原代生物医药科技有限公司
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