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Use of cannabidiol in the preparation of anti-influenza medicine

A technology of cannabidiol and use, which is applied in the field of cannabidiol in the preparation of anti-influenza drugs, can solve the problems of high patient mortality and achieve the effect of inhibiting influenza virus

Active Publication Date: 2021-04-30
HANYI BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But even with Tamiflu, patients with H5N1 avian influenza have a high mortality rate, and strains resistant to Tamiflu are constantly being isolated.

Method used

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  • Use of cannabidiol in the preparation of anti-influenza medicine
  • Use of cannabidiol in the preparation of anti-influenza medicine
  • Use of cannabidiol in the preparation of anti-influenza medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0120] Embodiment 1: Animal experiment of cannabidiol anti-influenza A virus H1N1

[0121] 1. Experimental Animals and Preliminary Preparations

[0122] Six-week-old Kunming white male mice were purchased from Beijing Weitong Lihua Experimental Technology Co., Ltd.

[0123] Animals were routinely reared in the P2 and P3 animal centers (Biosafety level2 and 3, P2 / P3) of the Institute of Microbiology, Chinese Academy of Sciences. The photoperiod was 12 hours of light / 12 hours of darkness, and the animals had free access to food and water. Animals were adapted to the new environment for 1 day before relevant experiments. Animal experiments were approved by China Agricultural University and the Animal Ethics Committee of the State Key Laboratory of Agricultural Biotechnology (SKLAB-2017-3-002).

[0124] 9-11 day-old SPF chicken embryos were purchased from Beijing Meriyawei Experimental Animal Technology Co., Ltd.

[0125] 2. Experimental method

[0126] (1) Chicken embryo am...

Embodiment 2

[0203] Example 2: In vitro experiment of cannabidiol inhibiting RNA polymerase of influenza A virus H1N1

[0204] The passaged mouse bone marrow derived macrophages (bone-marrow derived macrophage, BMDM) and human non-small cell lung cancer cell line A549 ( CCL-185 TM ), inoculated in 6-well plate, and divided into the following 4 groups:

[0205] Control group (high glucose medium DMEM, the manufacturer is Sigma, the product number is D5648-1L, diluted to 1 liter with purified water before the experiment),

[0206] H1N1 infected control group,

[0207] CBD group (5μM) and

[0208] Tamiflu group (10 μM).

[0209] The above 4 groups were cultured overnight at 37°C, and the cells were infected with H1N1WSN when the confluence reached 100% and there was no gap between the cells within 18-24 hours. Cells were infected for 1 h at MOI=0.01.

[0210] The supernatant was aspirated and discarded, and the same volume of serum-free medium containing PBS, Tamiflu and CBD was adde...

Embodiment 3

[0223] Embodiment 3: The experiment of cannabidiol anti-influenza A virus H5N1

[0224] 1. Experimental Animals and Preliminary Preparation

[0225] 6-week-old C57BL / 6 male mice were purchased from Beijing Weitong Lihua Experimental Technology Co., Ltd.

[0226] Consistent with the conditions of Example 1. Animals were routinely reared in P2 and P3 Animal Centers (Biosafety level 2 and 3, P2 / P3) of the Institute of Microbiology, Chinese Academy of Sciences. The photoperiod was 12 hours of light / 12 hours of darkness, and the animals had free access to food and water. Animals were adapted to the new environment for 1 day before relevant experiments. Animal experiments were approved by China Agricultural University and the Animal Ethics Committee of the State Key Laboratory of Agricultural Biotechnology (SKLAB-2017-3-002).

[0227] C57BL / 6 male mice were randomly divided into 2 groups, with 10 mice in each group. From the 4th day of infection, intraperitoneal injection was adm...

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Abstract

The invention belongs to the field of biomedicine and relates to the use of cannabidiol in the preparation of anti-influenza drugs. Specifically, the present invention relates to the use of any one of the following (1)-(3) in the preparation of medicines for treating or preventing influenza or medicines for relieving influenza symptoms: (1) cannabidiol or its pharmaceutical Acceptable salt or ester; (2) plant extract containing cannabidiol; preferably, cannabis extract containing cannabidiol; preferably, industrial hemp extract containing cannabidiol; (3) drug The composition contains an effective amount of cannabidiol or a pharmaceutically acceptable salt or ester thereof, and one or more pharmaceutically acceptable auxiliary materials. Cannabidiol can effectively inhibit influenza virus and has the potential to be prepared or used as a medicine for treating or preventing influenza.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to the use of cannabidiol in the preparation of anti-influenza drugs. Background technique [0002] Influenza, referred to as influenza (Influenza), is an acute respiratory infectious disease caused by influenza virus (Influenza Virus) caused by humans, poultry, and animals. Diseases that threaten human health. [0003] Influenza virus is a causative agent of influenza transmitted through the acute respiratory tract, belongs to the family Orthomyxoviridae, and is a single-stranded negative-sense RNA virus. Influenza viruses can be divided into three types according to their nucleoprotein (NP) and matrix protein (M) antigenicity (Hay et al. ,2001). Among them, Influenza A Virus (IAV) is the most common and the greatest threat to humans, which can cause influenza seasonal and regional outbreaks. In addition to infecting humans, it can also cause infections in various animals such as poultr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/05A61K36/185A61K45/06A61P31/16
CPCA61K31/05A61K36/185A61K45/06
Inventor 张可谭昕李向东于朝晖
Owner HANYI BIO TECH CO LTD
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