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Pharmaceutical composition for treating hand-foot-and-mouth disease

A hand-foot-mouth disease and composition technology, which is applied in the field of pharmaceutical compositions for treating hand-foot-mouth disease, can solve the problems of limited application, poor curative effect, high toxicity, etc., and achieve the effect of simple preparation, remarkable effect, and suitable for industrial production

Inactive Publication Date: 2019-03-05
烟台赛达医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the drugs for treating HFMD are mainly chemical synthetic drugs, but the existing chemical drugs have poor curative effect and high toxicity, so they should be further improved.
[0003] Chitosan is a secondary product of chitin, which has multiple functions such as antibacterial, antitumor, blood lipid regulation, immune regulation and wound repair promotion. However, it is easily soluble in acid and difficult to dissolve in water, which greatly limits its Applications in the field of biomedicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation (enzyme method) of embodiment 1 chitosan oligosaccharides

[0022] Chitosan 10g (derived from deep-sea white shrimp, deacetylation degree 95%, moisture 4.5%, ash content 0.5%, viscosity-average molecular weight 100,000, purchased from Zhejiang Golden Shell Biotechnology Co., Ltd.) was dissolved with 400ml of acetic acid, chitosan The sugar concentration is 0.025g / ml, add bromelain and chitosan endonuclease (weight percentage 45%:55%) mixed enzyme 5ml (enzyme content 50u) hydrolysis, 50 ℃ of hydrolysis after 30mim adjust the pH value to 6.3 , continue to degrade at 55°C for 3.5h, inactivate the enzyme at 110°C for 15min, centrifuge to take the supernatant, and freeze-dry to obtain 9.4g of chitosan oligosaccharides. Through LC-MS test, it is confirmed that it is oligomeric chitosan, the average molecular weight is 1720, and the purity is more than or equal to 98.5%.

Embodiment 2

[0023] The preparation of embodiment 2 pharmaceutical compositions

[0024] Oligomeric chitosan: the average molecular weight is 1720, the purity is more than or equal to 98.5%, and it is prepared in Example 1.

[0025] Puhuang, Sophora japonica, Mengzi Magnolia, Bowl Flowers, and Sleeping Vegetables are all commercially available.

[0026] Take a 1000ml flask, add 5g bowl of flowers, 5g Sophora japonica, 5g Mengzi Magnolia, 3g Puhuang, 3g Drowsy and mix with 500ml60% ethanol, stir well to make it even, heat and reflux for 3 hours, then cool to 2°C , After standing for 24 hours, the insoluble matter was removed by filtration, and the filtrate was concentrated to dryness to obtain 2.25 g of solid. Add 80ml of distilled water to dissolve, cool to 2°C, let stand for 48 hours, filter out insoluble matter, then add 5g of chitosan oligosaccharide, stir to make it fully dissolved, add distilled water to make the volume to 100ml, and obtain the pharmaceutical composition.

Embodiment 3

[0027] The preparation of embodiment 3 pharmaceutical compositions

[0028] Oligomeric chitosan: the average molecular weight is 1720, the purity is more than or equal to 98.5%, and it is prepared in Example 1.

[0029] Puhuang, Sophora japonica, Mengzi Magnolia, Bowl Flowers, and Sleeping Vegetables are all commercially available.

[0030] Take a 1000ml flask, add 4g bowl of flowers and plants, 6g Sophora japonica, 2g Mengzi Magnolia, 5g Puhuang, 2g Sombra and 500ml of 60% ethanol, mix well, stir well to make it even, heat and reflux for 3 hours, then cool to 2°C , After standing for 24 hours, the insoluble matter was removed by filtration, and the filtrate was concentrated to dryness to obtain 2.34 g of solid. Add 80ml of distilled water to dissolve, cool to 2°C, let stand for 48 hours, filter out insoluble matter, then add 5g of chitosan oligosaccharide, stir to make it fully dissolved, add distilled water to make the volume to 100ml, and obtain the pharmaceutical composit...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating hand-foot-and-mouth disease. The pharmaceutical composition is characterized by comprising, by weight, 2-8% of chitosan oligosaccharide, 1-10% of thunbergia fragrans, 2-8% of flos sophorae , 1-10% of herba shuteriae pampaninianae, 1-5% of pollen typhae, 1-5% of folium seu herba menyanthis trifoliatae, and 54-93% of distilled water.The pharmaceutical composition has high suppression capacity to the hand-foot-and-mouth disease according to virus inhibition tests, can be used for treatment of the hand-foot-and-mouth disease, and has high clinical application value and social benefit; the preparation method is simple and adaptable to industrial production.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for treating hand, foot and mouth disease. Background technique [0002] Hand, foot and mouth disease is a common childhood infectious disease, also known as exanthematous vesicular stomatitis, which mostly occurs in children under 5 years old and can cause herpes on the hands, feet, and oral cavity. Ulcers formed after herpes or ulceration are the main clinical symptoms. There are more than 20 types of enteroviruses that cause HFMD, among which enterovirus 71 (EV 71) is the most common. At present, the drugs for the treatment of hand, foot and mouth disease are mainly chemical synthetic drugs, but the existing chemical drugs have poor curative effect and high toxicity, so they should be further improved. [0003] Chitosan is a secondary product of chitin, which has multiple functions such as antibacterial, antitumor, blood lipid regulation, immune re...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61P31/14C12P19/26C12P19/14A61K31/722
CPCA61K31/722A61K36/19A61K36/48A61K36/489A61K36/51A61K36/88A61K2236/333A61K2236/51C12P19/14C12P19/26A61K2300/00
Inventor 翟维伟
Owner 烟台赛达医疗科技有限公司
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