Determination method of zinc in calcium zinc gluconate oral solution
A technology of calcium zinc gluconate and oral solution, which is applied in the direction of chemical analysis by titration method, can solve the problems of inaccurate evaluation of zinc content, etc., achieve stable color performance, high accuracy and durability, and save experiments The effect of the reagent
Inactive Publication Date: 2019-03-08
重庆健能医药开发有限公司
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Problems solved by technology
When using this method to titrate to the end point, the color is orange-yellow and cannot reach yellow, and the color change at the end point of the titration is sensitive, and there is an indicator blocking phenomenon, which cannot accurately evaluate the zinc content in calcium zinc gluconate oral solution
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Embodiment Construction
[0011] In order to confirm the effect of the assay method of the present invention, the inventor has carried out a large number of experiments, and has carried out scientific verification to the finally determined assay method, verification experiment is as follows:
[0012] method selection
[0013] Method 1: Take 50ml of sample, add 25ml of acetic acid-sodium acetate buffer solution (pH6.0), 5 drops of xylenol orange indicator solution;
[0014] Method 2: Take 50ml of sample, add 10ml of water, add 5ml of ammonia-ammonium chloride buffer solution (pH10.0), add 1g of ammonium fluoride and a little of chrome black T indicator;
[0015] Method 3: Take 50ml of sample, add 50ml of water, add 5ml of ammonia-ammonium chloride buffer solution (pH10.0) and a little chrome black T indicator;
[0016] Method 4: Take 50ml of the sample, add water to 200ml, add 50mg of xylenol orange and hexamethylenetetramine until the solution turns purple, and add an additional 2g of hexamethylenetet...
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The invention provides a determination method of zinc in a calcium zinc gluconate oral solution. The determination method comprises the following steps: accurately measuring and taking 50 ml of the oral solution, adding 25 ml of an acetic acid-sodium acetate buffering solution with pH of 6.0, 8 ml of an ascorbic acid solution with the concentration of 17.6 g / L and 3 ml of a tartaric acid solutionwith the concentration of 15 g / L, adding 5 droplets of a xylenol orange indicator solution, titrating by using an ethylenediamine tetraacetic acid titration solution with the concentration of 0.05 mol / L till red color is changed into yellow color and recording volume (V2) of the consumed titration solution, wherein 1 ml (V2) of the ethylenediamine tetraacetic acid titration solution with the concentration of 0.05 mol / L is equivalent to 22.78 mg of zinc gluconate. The method is capable of meeting the requirements for precision, accuracy and durability of the experiment, and is also capable of saving experiment reagents and reducing experiment cost.
Description
technical field [0001] The invention relates to a method for determining zinc content in calcium zinc gluconate oral solution. In the titration process, ascorbic acid and tartaric acid are used as masking agents to eliminate interference. Background technique [0002] Calcium zinc gluconate oral solution is used for the treatment of diseases caused by calcium deficiency and zinc, including osteoporosis, tetany, bone hypoplasia, rickets, calcium supplementation for pregnant women, lactating women, menopausal women, growth and development of children Slowness, loss of appetite, anorexia, recurrent oral ulcers and hemorrhoids, etc. [0003] Zinc is an important component of multiple enzymes in the body, which can promote growth and development, improve taste, etc. When it is lacking, growth stagnation, reproductive impotence, wound healing is difficult, the body is weak, and conjunctivitis, stomatitis, glossitis, and appetite can also occur. Deficiency, loss of taste, and neur...
Claims
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IPC IPC(8): G01N31/16
CPCG01N31/16
Inventor 李朝阳冉小琴江燕刘萍白晓红
Owner 重庆健能医药开发有限公司