Preparation process for volatile oil embedded particles of acorus tatarinowii

A preparation process and technology of volatile oil, which is applied in the field of preparation of volatile oil-embedded particles of Shichangpu, which can solve the problems of low extraction rate of volatile oil, high cost, and difficult application

Inactive Publication Date: 2019-03-15
KANGMEI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The extraction rate of volatile oil by boiling method and steam distillation method is not high, but the cost of supercritical fluid method is relatively high, and it is difficult to apply to the process of ordinary traditional Chinese medicine preparations.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A kind of preparation technology of Shichangpu volatile oil embedding particle, comprises the following steps:

[0033] 1) Grind 1kg of Acorus alba to 70 mesh, add 6.5L of water, and soak at 0-4°C for 18 hours;

[0034] 2) Warm up to room temperature, add 23 g of neutral cellulase to the feed liquid, and conduct ultrasonic-assisted enzymatic hydrolysis at 40°C for 2 hours to obtain an enzymatic hydrolysis solution;

[0035] 3) steam distillation, collecting the distillate, extracting with ether, drying with anhydrous sodium sulfate, and distilling under reduced pressure to obtain volatile oil;

[0036] 4) Add 15g of monoglyceride to 1L of water, shake, heat to 70°C, add β-cyclodextrin to make a saturated solution, and add 17.5vt% volatile oil;

[0037] 5) Heating the feed liquid in step 4) to 85°C for spray drying and granulation,

[0038] The spray drying conditions are: air inlet temperature 170°C, temperature inside the tower 92.5°C; blast frequency 35Hz, induced w...

Embodiment 2

[0040] A kind of preparation technology of Shichangpu volatile oil embedding particle, comprises the following steps:

[0041] 1) Grind 1 kg of Acorus calamus to 80 mesh, add 5 L of water, and soak at 0-4°C for 24 hours;

[0042] 2) Warm up to room temperature, add 10 g of neutral cellulase to the feed solution, and perform enzymatic hydrolysis at 35° C. for 2 hours to obtain an enzymatic hydrolysis solution;

[0043] 3) steam distillation, collecting the distillate, extracting with ether, drying with anhydrous sodium sulfate, and distilling under reduced pressure to obtain volatile oil;

[0044] 4) Add 10g of monoglyceride to 1L of water, shake, heat to 65°C, add β-cyclodextrin to make a saturated solution, and add 15vt% volatile oil;

[0045] 5) Heating the feed liquid in step 4) to 90°C for spray drying and granulation,

[0046] The spray drying conditions are: air inlet temperature 185°C, temperature inside the tower 95°C; blast frequency 40Hz, induced wind frequency 35H...

Embodiment 3

[0048] A kind of preparation technology of Shichangpu volatile oil embedding particle, comprises the following steps:

[0049] 1) Grind 1kg of Acorus alba to 60 mesh, add 8L of water, and soak for 12 hours at 0-4°C;

[0050] 2) Warm up to room temperature, add 40 g of neutral cellulase to the feed solution, and perform enzymatic hydrolysis at 45° C. for 2 hours to obtain an enzymatic hydrolysis solution;

[0051] 3) steam distillation, collecting the distillate, extracting with ether, drying with anhydrous sodium sulfate, and distilling under reduced pressure to obtain volatile oil;

[0052] 4) Add 20g of monoglyceride to 1L of water, shake, heat to 75°C, add β-cyclodextrin to make a saturated solution, and add 20vt% volatile oil;

[0053] 5) Heating the feed liquid in step 4) to 80°C, spray drying and granulating,

[0054] The spray drying conditions are: air inlet temperature 155°C, temperature inside the tower 90°C; blast frequency 30Hz, induced wind frequency 45Hz, atomi...

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PUM

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Abstract

The invention discloses a preparation process for volatile oil embedded particles of acorus tatarinowii. The preparation process for the volatile oil embedded particles of the acorus tatarinowii comprises the following steps: 1) grinding raw medicinal powder of the acorus tatarinowii, adding water which is 5 to 8 times of the weight, and soaking at the temperature of 0 to 4 DEG C for 12 to 24h; 2)rising to room temperature, adding 0.2 to 0.5wt% of neutral cellulase to a material solution, and performing enzymatic hydrolysis at the temperature of 35 to 45 DEG C for 1.5 to 3h to obtain enzymatic hydrolysate; 3) carrying out steam distillation, collecting distillate, extracting with diethyl ether, drying, and distilling under reduced pressure to obtain volatile oil; 4) adding 0.1 to 0.2wt% of monoglyceride to water, shaking, heating to the temperature of 65 to 75 DEG C, adding beta-cyclodextrin to prepare a saturated solution, and adding 15 to 20vt% of the volatile oil; 5) heating the material solution in the step 4) to the temperature of 80 to 90 DEG C, and carrying out spray-drying granulation. The preparation process can effectively improve the extraction rate of the volatile oilof the acorus tatarinowii and obtain stable embedded particles.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine processing, in particular to a preparation process for volatile oil-embedded particles of Acorus calamus. Background technique [0002] Calamus calamus (Latin scientific name: Acorus tatarinowii), belongs to Araceae, Calamus is a grass-like perennial herb, and its rhizome has an odor. [0003] The rhizomes of calamus calamus contain volatile oil, the main components of which include ethers, esters, aldehydes, and phenols. Its physical and chemical properties are not stable, and it is easy to volatilize or be easily oxidized under conditions such as heat and light. The extraction methods of the volatile oil of Acorus calamus include boiling, steam distillation and supercritical fluid extraction. The extraction rate of volatile oil in the boiling method and the steam distillation method is not high, and the cost of the supercritical fluid method is relatively high, and it is di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/888A61K47/69A61K125/00
CPCA61K36/888A61K2236/19A61K2236/331A61K2236/35A61K2236/51A61K47/6951
Inventor 曾国荣许冬瑾房燕洲林哲行王文涛李宏锋杨学慧
Owner KANGMEI PHARMA
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