Biological component adhesion-suppressing material
A biological and polymer technology, applied in the field of blood purifiers, can solve the problems of low recovery rate and other problems
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0171] A vinylpyrrolidone / vinyl hexanoate random copolymer was produced by the following method. Mix vinylpyrrolidone monomer (Wako Pure Chemical Industries) 16.2 g, vinyl caproate monomer (Tokyo Chemical Industry) 20.8 g, isopropanol (Wako Pure Chemical Industries) as a polymerization solvent 56 g, as a polymerization initiator Nitrobis(dimethylbutyronitrile) 0.35 g was stirred at 70° C. for 8 hours under a nitrogen atmosphere. The reaction solution was cooled to room temperature and concentrated, and the concentrated residue was poured into hexane. The precipitated white precipitate was collected and dried under reduced pressure at 50° C. for 12 hours to obtain 25.0 g of a vinylpyrrolidone / vinyl hexanoate random copolymer. according to 1 As a result of H-NMR measurement, the mole fraction of vinyl hexanoate units was 40%. According to the measurement result of GPC, the number average molecular weight was 2,200.
[0172] A 1.0% by weight aqueous ethanol solution in which ...
Embodiment 2
[0175] A hollow fiber membrane module was produced by the same means as in Example 1, except that the concentration of the copolymer during production of the hollow fiber membrane module was changed from 300 ppm to 500 ppm.
[0176]From the results of TOF-SIMS measurement and XPS measurement, it was confirmed that hexanoate was present on the surface of the functional layer of the hollow fiber membrane. In addition, according to the measurement results of ATR-IR, it can be seen that at 1711~1751cm -1 、1617~1710cm -1 and 1549~1620cm -1 There are peaks in the range. According to the measurement results of ATR-IR, it can be known that the amount of copolymer immobilized on the inner surface of the hollow fiber membrane (1711~1751cm -1 The range of peak areas A C=O 、1549~1620cm -1 The range of peak areas A C=C The ratio of A C=O / A C=C The average value) is 0.08. The relative attachment amount of fibrin was measured on the fabricated hollow fiber membrane module. The res...
Embodiment 3
[0178] A vinylpyrrolidone / vinyl propionate random copolymer was produced by the following method. Mix 19.5 g of vinylpyrrolidone monomers, 17.5 g of vinyl propionate monomers, 56 g of t-amyl alcohol as a polymerization solvent, and 2,2'-azobis(2,4-dimethylvaleronitrile as a polymerization initiator) ) 0.175 g, stirred at 70° C. for 6 hours under a nitrogen atmosphere. The reaction solution was cooled to room temperature to terminate the reaction, concentrated, and poured into hexane. The precipitated white precipitate was collected and dried under reduced pressure to obtain 21.0 g of a copolymer.
[0179] according to 1 As a result of H-NMR measurement, the mole fraction of vinyl propionate units was 40%. In addition, according to the measurement result of GPC, the number average molecular weight was 16,500.
[0180] A hollow fiber membrane module was produced in the same manner as in Example 1 except that a vinylpyrrolidone / vinyl propionate random copolymer was used inste...
PUM
| Property | Measurement | Unit |
|---|---|---|
| Peak area | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More