Copolymer, separation membrane using same, medical device, and blood purifier
A technology of copolymers and separation membranes, applied in other medical devices, pharmaceutical devices, separation methods, etc., to achieve high water permeability, high usefulness, and maintain water permeability
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Embodiment 1）
[0273] A vinylpyrrolidone / vinyl propionate random copolymer was produced by the following method. 19.5 g of vinylpyrrolidone monomer, 17.5 g of vinyl propionate monomer, 56 g of tert-amyl alcohol as a polymerization solvent, and 2,2'-azobis(2,4-dimethylvaleronitrile as a polymerization initiator ) 0.175 g was mixed, and stirred at 70° C. for 6 hours in a nitrogen atmosphere. The reaction solution was cooled to room temperature to terminate the reaction, concentrated, and poured into hexane. The precipitated white precipitate was recovered and dried under reduced pressure to obtain 21.0 g of a copolymer. Depend on 1 As a result of H-NMR, it was known that the mole fraction of vinylpyrrolidone monomer units was 60%. In addition, according to the measurement result of GPC, the number average molecular weight was 16,500.
[0274] A medical separation membrane module having the shape of a hollow fiber membrane in which the produced vinylpyrrolidone / vinyl propionate random copol...
Embodiment 2）
[0275] (Example 2) Instead of the vinylpyrrolidone / vinyl propionate random copolymer, a vinylpyrrolidone / vinyl pivalate random copolymer was used (the mole fraction of vinylpyrrolidone monomer units was 70%, several The average molecular weight is 3,900), except that, in the same manner as in Example 1, a medical separation membrane module was produced, and the water permeability reduction rate, platelet adhesion amount, and albumin sieving coefficient were measured. As a result, as shown in Table 1, the decrease rate of water permeability was 9%, the amount of platelet adhesion was 0, and the decrease rate of albumin sieving coefficient after perfusion time from 10 minutes to 60 minutes was 3%.
[0276] (Example 3) A vinylpyrrolidone / vinyl propionate random copolymer (the mole fraction of vinylpyrrolidone monomer units is 70%, and the number average molecular weight is 20,800) was used. Similarly, a separation membrane module for medical use was produced, and the water permea...
Embodiment 6）
[0279] (Example 6) Instead of the vinylpyrrolidone / vinyl propionate random copolymer, a vinylpyrrolidone / vinyl caprate random copolymer was used (the mole fraction of vinylpyrrolidone monomer units was 80%, the number average The molecular weight is 19,000), and in the same manner as in Example 1, a medical separation membrane module was produced, and the water permeability reduction rate, platelet adhesion amount, and albumin sieving coefficient were measured. As a result, as shown in Table 1, the decrease rate of water permeability was 3%, the number of platelets attached was 2, and the decrease rate of albumin sieving coefficient after perfusion time was 10 minutes to 60 minutes was 17%.
[0280] (Example 7) Instead of the vinylpyrrolidone / vinyl propionate random copolymer, a vinylpyrrolidone / vinyl nonanoate random copolymer was used (the molar fraction of vinylpyrrolidone monomer units was 80%, the number average The molecular weight is 4,400), and in the same manner as in...
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