Method of catalyzing polymerization of lactide by using anilido-imine magnesium complex

A technology of amine imine magnesium and complexes, which is applied in the field of catalytic lactide polymerization, can solve the problems of metal residues, and achieve the effects of low cost, controllable molecular weight and high catalytic activity

Active Publication Date: 2019-03-19
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, one problem that still needs to be solved is that there will inevitably be metal residues in the products made by metal complex catalysts, and it is almost impossible to completely remove these residues from the polymer, so low-toxic magnesium complexes Become a more promising catalyst, especially when the polymer is used in the field of biomedicine, this type of catalyst is more important

Method used

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  • Method of catalyzing polymerization of lactide by using anilido-imine magnesium complex
  • Method of catalyzing polymerization of lactide by using anilido-imine magnesium complex
  • Method of catalyzing polymerization of lactide by using anilido-imine magnesium complex

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Experimental program
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Effect test

Embodiment 1

[0037] The structural formula of the ligand used is the above formula (A), where R is hydrogen, and the reaction process is as follows: under a nitrogen atmosphere, slowly add 5 mL of benzyl alcohol tetrahydrofuran solution (2.0 mol / L) to an equimolar amount of Mg( n Bu) 2 Hexane solution (2.0 mol / L, 5 mL) was reacted for 1 hour, then 2.72 g of the ligand was dissolved in 15 mL of dry toluene, and added to Mg( n Bu) 2In the reaction mixture with benzyl alcohol, after adding, let the reaction liquid rise to room temperature naturally, then heat to 60°C for 1 hour, after the reaction is completed, the solvent is vacuum-dried, and the residue is washed with dry n-hexane, filtered, and then the product is collected and dried Weighed to obtain 3.43 g of solid, the yield was 85.3%.

Embodiment 2

[0039] The structural formula of the ligand used is the above formula (A), where R is a methyl group, and the reaction process is as follows: under a nitrogen atmosphere, slowly add 5 mL of benzyl alcohol tetrahydrofuran solution (2.0 mol / L) to an equimolar amount of Mg( n Bu) 2 Hexane solution (2.0 mol / L, 5 mL) was reacted for 1 hour, then 3.28 g of the ligand was dissolved in 20 mL of dry toluene, and added to Mg( n Bu) 2 and benzyl alcohol reaction mixture, after adding, the reaction liquid was naturally raised to room temperature, and then heated to 40 ° C for 12 hours, after the reaction was completed, the solvent was vacuum-dried, and the residue was washed with dry n-hexane, filtered, and then the product was collected and dried Weighed to obtain 4.07g of solid, the yield was 88.9%.

Embodiment 3

[0041] The structural formula of the ligand used is the above formula (A), where R is ethyl, and the reaction process is as follows: under a nitrogen atmosphere, slowly add 5 mL of benzyl alcohol tetrahydrofuran solution (2.0 mol / L) to an equimolar amount of Mg( n Bu) 2 Hexane solution (2.0 mol / L, 5 mL) was reacted for 1 hour, then 3.84 g of the ligand was dissolved in 25 mL of dry toluene, and added to Mg( n Bu) 2 and benzyl alcohol reaction mixture, after adding, the reaction solution was naturally raised to room temperature, and then heated to 50 ° C for 3 hours, after the reaction was completed, the solvent was vacuum-dried, and the residue was washed with dry n-hexane, filtered, and then the product was collected and dried Weighed to obtain 4.17g of solid, the yield was 81.2%.

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Abstract

The invention discloses a method of catalyzing polymerization of lactide by using an anilido-imine magnesium complex. The method comprises the step of catalyzing polymerization of lactide in a water-and oxygen-free condition and under protection of inert gas by taking the anilido-imine magnesium complex as a catalyst and lactide as a raw material to obtain polylactide. By carrying out a ring-opening polymerization reaction on lactide by taking the independently researched and developed anilido-imine magnesium complex as the catalyst, the preparation method of the catalyst is simple, the costis low, and the structure changes are diversified. The metal center magnesium coordinates with N, N atoms of a ligand, so that the catalyst is high in activity, high in stereoselectivity, free of a cocatalyst and high in reaction speed, and is the quite ideal catalyst. When the ring-opening polymerization reaction is carried out on lactide by the independently researched and developed anilido-imine magnesium complex, the molecular weight of the polymer obtained by the reaction is narrow in distribution and controllable, and the polymer is high in yield, high in selectivity and has a very goodapplication prospect.

Description

technical field [0001] The invention relates to a method for catalyzing the polymerization of lactide, in particular to a method for catalyzing the polymerization of lactide by using an amine-imine magnesium complex. Background technique [0002] With the enhancement of people's awareness of environmental protection, the development of degradable biomaterials that can reduce environmental pollution has become one of the important research fields of polymer materials. Polylactone is a biodegradable, green and environment-friendly polymer material, and it has attracted more and more attention as a substitute for petroleum products. In the natural living environment, waste polylactone materials can be completely decomposed into small molecules by microorganisms in the soil. Because polyester is non-toxic, non-irritating, and has good biocompatibility, it is widely used in medical and environmental protection fields, such as surgical sutures, packaging, drug controlled release,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/83C08G63/08
CPCC08G63/08C08G63/823
Inventor 姚伟蒋茜茜丁蕊齐学袖王蕾杨路平王洪宾顿爱社孙丰刚张海东于广福游淇
Owner UNIV OF JINAN
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