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A method for preparing cryptoxanthin from marigold extract

A technology of marigold and cryptoxanthin, applied in the direction of organic chemistry, etc., can solve the problems of incapable of large-scale production, difficult process realization, high cost, etc., and achieve the effects of convenient large-scale production, high product purity, and convenient separation

Active Publication Date: 2020-12-22
山东天音生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, both natural sources and artificial synthesis methods have the disadvantages of less raw materials and difficult process realization, resulting in high cost and inability to produce on a large scale

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 1) Marigold extract, sodium ethoxide and tea polyphenols were prepared at a mass ratio of 100:22:1.2, and then reacted at 70°C for 2 hours under the protection of nitrogen;

[0021] 2) Add hydrochloric acid to adjust the pH to 2, stir at 75°C for 0.5h, lutein is converted into cryptoxanthin under acid catalysis, and stand to separate the bottom water layer to obtain the upper part including cryptoxanthin;

[0022] 3) Add a mixture of ethanol and n-hexane to the mixture obtained in step 2) for dilution. The mass ratio of ethanol and n-hexane in the mixture is 1:1, heat at 54°C for 2.0h, cool down to 15°C to crystallize, and separate the solid and liquid. Obtained, the yield is 87%, and the content of cryptoxanthin in the product obtained is 89%.

Embodiment 2

[0024] 1) Marigold extract, sodium methoxide and vitamin E were prepared at a mass ratio of 100:25:1, and then reacted at 80°C for 2.5 minutes under the protection of nitrogen;

[0025] 2) Add sulfuric acid to adjust the pH to 3, stir at 80°C for 0.5h, the lutein is converted into cryptoxanthin under acid catalysis, and let stand to separate the bottom water layer to obtain the upper part including cryptoxanthin;

[0026] 3) Add a mixture of ethanol and n-hexane to the mixture obtained in step 2) for dilution. The mass ratio of ethanol and n-hexane in the mixture is 1:0.8, heat at 55°C for 2.0h, cool down to 13°C to crystallize, and separate the solid and liquid. Obtained, the yield is 86%, and the content of cryptoxanthin in the product obtained is 87%.

Embodiment 3

[0028] 1) Marigold extract, potassium ethoxide and TBHQ were prepared at a mass ratio of 100:17:1.5, and then reacted at 55°C for 3 hours under the protection of nitrogen;

[0029] 2) Add hydrochloric acid to adjust the pH to 2, stir at 70°C for 0.7h, the lutein is converted into cryptoxanthin under acid catalysis, and stand to separate the bottom water layer to obtain the upper part including cryptoxanthin;

[0030] 3) Add a mixture of ethanol and n-hexane to the mixture obtained in step 2) for dilution. The mass ratio of ethanol and n-hexane in the mixture is 1:1.2, heat at 53°C for 1.9h, cool down to 17°C to crystallize, and separate the solid and liquid. Obtained, the yield is 85%, and the content of cryptoxanthin in the product obtained is 88%.

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Abstract

The invention discloses a method for preparing kryptoxanthin from a marigold ointment and belongs to the technical field of carotenoid preparation. The method is characterized by comprising the following preparation processes: carrying out a heating reaction on the marigold ointment, an alkali and an antioxidant, adding an acid to adjust the pH value to 1-4, transforming xanthophylls into kryptoxanthin under catalysis of the acid, and leaving to stand and separating; and diluting with a mixed liquid of ethanol and normal hexane, cooling to 10-20 DEG C to implement crystallization, and carryingout solid-liquid separation, thereby obtaining the kryptoxanthin. The invention provides the method for preparing kryptoxanthin from the natural extract, namely the marigold ointment, through hydrolysis and acid treatment. The raw materials are natural and easy to obtain, and meanwhile, on-scale production is convenient to implement. The content of kryptoxanthin in the obtained product is 80% orgreater.

Description

technical field [0001] A method for preparing cryptoxanthin from marigold extract belongs to the technical field of carotenoid preparation. Background technique [0002] Cryptoxanthin is a carotenoid with good antioxidant properties. It has unique functions in anti-cancer, enhancing immunity and reducing the incidence of cardiovascular diseases. Cryptoxanthin can promote the synthesis of human protein and prevent the loss of protein. At the same time, cryptoxanthin has a coloring function. Cryptoxanthin sources include natural sources and synthetics. Natural sources of cryptoxanthin are mainly extracted from fungi, cyanobacteria and orange peel, and synthesized mainly from isoprenoids or converted from carotenoids. However, both natural sources and artificial synthesis methods have the disadvantages of less raw materials and difficult process realization, resulting in high cost and incapable of large-scale production. Contents of the invention [0003] The technical pro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C403/24
CPCC07C403/24C07C2601/16
Inventor 刘温来李勇田芸殷东东赵晨光
Owner 山东天音生物科技有限公司
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