Preparation method of GO (Graphene Oxide)/NiCO LDHs catalytic material for detecting glucose and electrochemical sensor

A technology of catalytic materials and sensors, applied in electrochemical variables of materials, scientific instruments, analytical materials, etc., can solve the problems of complex immobilization process, high price, restricting the application scope of enzyme sensors, etc.

Inactive Publication Date: 2019-03-22
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In recent years, glucose sensors have been a hot topic of research by scholars. Glucose sensors are divided into enzyme sensors and enzyme-free electrochemical sensors. The stability and importance of enzyme sensors are relatively poor, mainly due to the fact that the enzyme itself is easily affected by the environment. Moreover, the price is expensive and the immobilization

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] (1) First, disperse 8-20 mg of graphene oxide (GO) in 50 ml of anhydrous methanol, and sonicate for 0.5-2 hours to obtain graphene oxide dispersion A.

[0013] (2) Take 0.498g of cobalt nitrate hexahydrate and add it to the dispersion A, and sonicate it for 0.5~2h to obtain solution B; dissolve 0.656g of dimethylimidazole in 50ml of anhydrous methanol, slowly add it into solution B, and stir After 10-15 minutes, let it stand at room temperature for 24-48 hours to obtain solution C, which was collected by suction filtration and centrifuged and washed n times with anhydrous methanol to obtain a purple-black precipitate, which was vacuum-dried at 60°C for 12-24 hours. The product GO@ZIF-67 was obtained.

[0014] (3) Take 5-20 mg of GO@ZIF-67 and disperse it in 15 ml of absolute ethanol, sonicate for 20-30 minutes to obtain solution D; take an appropriate amount of nitric acid hexahydrate at a mass ratio of 1:1 (GO@ZIF-67: nickel nitrate hexahydrate) Dissolve nickel in 15m...

Embodiment 2

[0017] Changing the mass ratio of GO@ZIF-67 to nickel nitrate hexahydrate to 1:2, it was measured that it had an obvious oxidation peak at 0.438V and an obvious reduction peak at 0.348V when the glucose concentration was 1mmol / L.

Embodiment 3

[0019] Changing the mass ratio of GO@ZIF-67 to nickel nitrate hexahydrate to 1:3, it was measured that it had an obvious oxidation peak at 0.481V and an obvious reduction peak at 0.362V when the glucose concentration was 1mmol / L.

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Abstract

The invention discloses a preparation method of a GO (Graphene Oxide)/NiCO LDHs catalytic material for detecting glucose and an electrochemical sensor. The preparation method comprises the following steps: firstly, dispersing graphene oxide (GO) into absolute methanol to obtain a graphene oxide dispersion solution; synthesizing GO@ZIF-67 by utilizing cobalt nitrate hexahydrate and dimethylimidazole; then carrying out hydrothermal synthesis on the GO@ZIF-67 and the nickel nitrate hexahydrate to obtain the GO/NiCO LDHs catalytic material; finally, dropwise adding a catalytic material solution onto a cleaned bare glass carbon electrode, so as to obtain a GO/NiCO LDHs modified electrochemical sensor. According to the preparation method, good electrochemical performance of the graphene oxide, and a porous structure and a regular shape of an MOFs (Metal Organic Frameworks) material are combined; ZIF-67 is used as a sacrificial template and oriented growth of the NiCO LDHs catalytic materialis realized; the stability of the glucose electrochemical sensor is enhanced, a detection range is expanded, the detection cost is reduced and the sensitivity of detection is improved. An enzyme-freeelectrochemical sensor makes a breakthrough of improving the analytical performance including high stability, high sensitivity and high catalytic performance and.

Description

technical field [0001] The present invention relates to the technical field of electrochemical sensors, in particular to the field of enzyme-free glucose detection, in particular to a GO / NiCO LDHs catalytic material for glucose detection and a method for preparing an electrochemical sensor, which has been successfully applied to the detection of blood glucose concentration in humans. The invention belongs to the technical field of functional materials and electrochemical sensors. Background technique [0002] Glucose is the most common substance in daily life. It is of great significance to quickly and accurately analyze and detect its content in many fields such as clinical testing of diabetic patients and food industry. Undoubtedly, the development of an ideal glucose sensor must become the primary issue of the sensor industry, and there are many methods for detecting glucose. For example, high performance liquid chromatography, spectrophotometry, optical rotation, gas ch...

Claims

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Application Information

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IPC IPC(8): G01N27/48G01N27/30
CPCG01N27/308G01N27/48
Inventor 王丽丽李艳庭宋丹丹李尚真苗雪莉唐家俊秦皓沈彦妮
Owner TIANJIN POLYTECHNIC UNIV
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