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Preparation of magnetic targeting preparation

A magnetic targeting and preparation technology, which is applied in the field of analysis and medicine, can solve the problem that hydrophobic drugs cannot be loaded, and achieve the effects of improving drug efficacy, reducing dosage, and reducing side effects

Inactive Publication Date: 2019-03-26
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its hydrophilic property is too strong, causing some hydrophobic drugs to be loaded, so sodium alginate can be loaded with hydrophobic drugs after hydrophobic modification (Pourjavadi A, Amin S S, Hosseini S H.Ind.Eng.Chem. Res.2018,57:822-832)

Method used

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  • Preparation of magnetic targeting preparation
  • Preparation of magnetic targeting preparation

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Experimental program
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Embodiment Construction

[0030] According to the steps (1)-(3) of the technical scheme, HM-alginate micelles, drug-loaded micelles, and magnetic targeting preparations in aqueous solution are obtained, and the morphology is shown in figure 1 , figure 2 , wherein, sodium alginate was purchased from Qingdao Mingyue Seaweed Co., Ltd., dodecyl glycidyl ether (DGE), sodium dodecyl sulfate (SDS) were purchased from Maya Reagent, N-hydroxysuccinimide (NHS, 0.2M), 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) and doxorubicin (Dox) were purchased from aladdin.

[0031] According to the steps (3) and (4) of the technical scheme, the condition optimization experiment was carried out on the obtained magnetic targeting preparation, and the characterization was carried out by laser confocal microscopy. For details, see image 3 .

[0032] Table 1 Ratio optimization of experimental conditions for magnetically targeted drug carriers

[0033]

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Abstract

The invention relates to preparation of a magnetic targeting preparation. According to a main preparation method, magnetic microspheres with -NH2 are used as magnetic cores with a guiding effect, sodium alginate which can be self-assembled to form micelles in an aqueous solution after being modified is used as a medicine carrier skeleton material, and adriamycin amycin is used as a hydrophobic medicine which is wrapped in the micelles. Through chemical reaction, the magnetic targeting preparation is obtained, so that subsequent application of a magnetic targeting medicine carrier in the aspects of cell-mediated immunity and the like is achieved. The method is mainly characterized in that the magnetic targeting medicine carrier has targeting capability, experimental operation is simple, themagnetic targeting medicine carrier does not have toxic or side effects, the medicine-carrying micelles and the hydrophobic medicine in the aqueous solution can be separated, and the like.

Description

technical field [0001] The invention relates to the fields of analysis and medicine. The modified hydrophobically modified sodium alginate (HM-alginate), which can self-assemble into micelles in an aqueous solution, is used as a hydrophobic drug carrier to combine with -NH 2 The magnetic microspheres of the groups are connected, and the drug-loaded micelles in the aqueous solution are separated from the hydrophobic drugs by magnetic separation to prepare magnetic targeting preparations. Specifically relates to the preparation of a magnetic targeting drug carrier. Background technique [0002] The reason why magnetically targeted drugs can be applied to targeted therapy is mainly to treat lesion sites through magnetically targeted drug delivery systems. The basic principle of using magnetic-targeted drugs in magnetic-targeted drug delivery systems is: inject magnetic drug-loaded particles into the body, apply a magnetic field externally, and through the inductivity of the ex...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/704A61K41/00A61K47/36
CPCA61K41/00A61K47/36A61K9/0009A61K9/1075A61K31/704
Inventor 杨晓燕高雪秦海新于跃芹刘树峰
Owner QINGDAO UNIV OF SCI & TECH
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