A kind of dissolving method of sodium hyaluronate dosing process
A technology of sodium hyaluronate and formulations, which is applied in pharmaceutical formulations, chemical instruments and methods, detergent compounding agents, etc., can solve problems such as increased oxygen exposure, long dissolution time, and reduced production efficiency, so as to speed up the production process and dissolve The effect of time reduction and productivity improvement
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Embodiment 1
[0034] (1) Sodium hyaluronate and disodium edetate are uniformly mixed according to different mass ratios to obtain a solid mixture. The specific ratio and dosage of the two are shown in Table 1;
[0035] (2) Add the solid mixture into the stirring 100mL water, the stirring rate is 300r / min, measure the dissolution time of the solid mixture and observe the solution, and at the same time, use a single sodium hyaluronate at the same stirring speed to compare the dissolution rate , and the results are listed in Table 1.
[0036] Table 1 Comparison table of dissolving time of different proportions of sodium hyaluronate and disodium edetate
[0037]
[0038] It can be seen from Table 1 that disodium edetate can accelerate the dissolution of sodium hyaluronate as a water-soluble solid substance. Compared with dissolving sodium hyaluronate alone, the dissolution time is greatly reduced, and the obtained solution is clear, with uniform bubbles and less bubbles.
Embodiment 2
[0040] (1) Sodium hyaluronate and boric acid are uniformly mixed in different mass ratios to obtain a solid mixture. The specific ratio and consumption of the two are shown in Table 1;
[0041] (2) Add the solid mixture into 100mL water which is being stirred, the stirring speed is 650r / min, measure the dissolution time of the solid mixture and observe the solution, and at the same time use a single sodium hyaluronate at the same stirring speed to compare the dissolution speed , and the results are listed in Table 2.
[0042] Table 2 Comparison Table of Sodium Hyaluronate and Boric Acid Dissolving Time in Different Proportions
[0043]
[0044] It can be seen from Table 2 that boric acid, as a water-soluble solid substance, can accelerate the dissolution of sodium hyaluronate. Compared with dissolving sodium hyaluronate alone, the dissolution time is greatly reduced, and the resulting solution is clear, with uniform bubbles and less bubbles.
Embodiment 3
[0046] (1) Sodium hyaluronate and sodium chloride are uniformly mixed according to different mass ratios to obtain a solid mixture, and the specific ratio and consumption of the two are shown in Table 1;
[0047] (2) Add the solid mixture into the stirring 100mL water, the stirring rate is 150r / min, measure the dissolution time of the solid mixture and observe the solution, and at the same time, use a single sodium hyaluronate at the same stirring speed to compare the dissolution rate , and the results are listed in Table 3.
[0048] Table 3 Comparison Table of Sodium Hyaluronate and Sodium Chloride Dissolving Time in Different Proportions
[0049]
[0050] It can be seen from Table 3 that sodium chloride, as a water-soluble solid substance, can accelerate the dissolution of sodium hyaluronate. Compared with dissolving sodium hyaluronate alone, the dissolution time is greatly reduced, and the resulting solution is clear, with uniform bubbles and less bubbles.
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