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A preparation method for improving the fluidity of L-carnitine fumarate

A technology of L-carnitine fumarate and solution, which is applied in the fields of medicine, health care and food. It can solve the problems of easy coalescence and poor fluidity of L-carnitine fumarate, and achieves inhibition of coalescence and excellent fluidity , Weaken the effect of adsorption/stacking

Active Publication Date: 2022-03-01
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The technical problem to be solved in the present invention is: overcome existing L-carnitine fumarate fluidity poor, easily agglomeration etc. problem, provide a kind of preparation method that improves the fluidity of L-carnitine fumarate by controlling crystal morphology

Method used

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  • A preparation method for improving the fluidity of L-carnitine fumarate
  • A preparation method for improving the fluidity of L-carnitine fumarate
  • A preparation method for improving the fluidity of L-carnitine fumarate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] (1) Mix 12.70g of L-carnitine inner salt (L-carnitine) with 9.14g of fumaric acid, add to the mixed solvent of water-ethanol (8.5g of distilled water+79.0g of absolute ethanol), and dissolve the suspension The temperature was raised to 77°C. The solid is completely dissolved to obtain L-carnitine fumarate solution;

[0046] (2) The solution is subjected to the cooling crystallization of the first stage, under the action of stirring (rotating speed is set to 600rpm), the L-carnitine fumarate solution is cooled to 71°C at a speed of 18°C / hour, and an amount of solute equivalent to 1.75g ​​of 80-mesh seed crystal with a mass of 8.0%, and apply an ultrasonic field with a frequency of 60kHz for 5 minutes, and keep warm for 0.5 hours;

[0047] (3) The L-carnitine fumarate solution through step (2) is subjected to the cooling crystallization of the second stage, under stirring (rotating speed is set to 600rpm), the L-carnitine fumarate is mixed with the speed of 3° C. / hour C...

Embodiment 2

[0051] (1) Mix 8.84g of L-carnitine inner salt (L-carnitine) with 6.36g of fumaric acid, add to the mixed solvent of water-ethanol (6.2g of distilled water+63.2g of absolute ethanol), and dissolve the suspension The temperature was raised to 75°C. The solid is completely dissolved to obtain L-carnitine fumarate solution;

[0052] (2) The solution is subjected to the cooling crystallization of the first stage, under stirring (rotating speed is set to 500rpm), the L-carnitine fumarate solution is cooled to 68°C at a speed of 24°C / hour, and an amount of solute equivalent to 1.06g of 100-mesh seed crystal with a mass of 7.0%, and apply an ultrasonic field with a frequency of 50kHz for 10 minutes, and keep warm for 1 hour;

[0053] (3) Carry out the cooling crystallization of the second stage through the L-carnitine fumarate solution of step (2), under the action of stirring (rotating speed is set as 500rpm), with the speed of 5 ℃ / hour, L-carnitine fumarate Cool the salt solution...

Embodiment 3

[0057] (1) Mix 6.22g of L-carnitine inner salt (L-carnitine) with 4.47g of fumaric acid, add to the mixed solvent of water-ethanol (3.8g of distilled water+47.4g of absolute ethanol), and dissolve the suspension The temperature was raised to 72°C. The solid is completely dissolved to obtain L-carnitine fumarate solution;

[0058] (2) The solution is subjected to the cooling crystallization of the first stage, under stirring (rotating speed is set to 400rpm), the L-carnitine fumarate solution is cooled to 66°C at a speed of 30°C / hour, and an amount of solute equivalent to 0.64g of 120-mesh seed crystal with a mass of 6.0%, and apply an ultrasonic field with a frequency of 40kHz for 15 minutes, and keep warm for 1.5 hours;

[0059] (3) Carry out the cooling crystallization of the second stage through the L-carnitine fumarate solution of step (2), under the action of stirring (rotating speed is set as 400rpm), with the speed of 6 ℃ / hour, L-carnitine fumarate Cool the salt solut...

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Abstract

The invention relates to a preparation method for improving the fluidity of L-carnitine fumarate. The present invention is based on the solution cooling crystallization technology, by adjusting the initial concentration of the solution, the solvent ratio, the cooling curve, the size and input amount of the seed crystal, and finally adopting operations such as segmented cooling curve, multiple addition of the crystal seed combined with ultrasonic interference, etc., to prepare the Oblong sheet-shaped L-carnitine fumarate with a certain thickness. The L-carnitine fumarate product obtained by the method is monodisperse and non-agglomerated, has a certain thickness of rectangular flaky crystals, has a large particle size D50: 580-650 microns, excellent fluidity, and an angle of repose <32°. The problem of poor fluidity and easy coalescence of the existing L-carnitine fumarate is overcome, and the mass yield is as high as over 80%, which is suitable for large-scale industrial production.

Description

technical field [0001] The invention belongs to the fields of medicine, health care and food, and in particular relates to a preparation method for improving the fluidity of L-carnitine fumarate. Background technique [0002] L-carnitine (L-carnitine), also known as L-carnitine, is a white lens or white transparent fine powder. It was discovered by Russian scientists as early as 1905, and then it has been continuously developed in the course of a century-long research. More and more functions have been discovered and valued, and people are paying more and more attention to it. As an important food nutrition enhancer, L-carnitine is widely used in infant milk powder, diet food, sports nutrition and nutritional supplements for middle-aged and elderly people. At the same time, L-carnitine also has medical effects. Improve cardiovascular disease, liver disease, kidney disease, hyperlipidemia, diabetes and neuromuscular disease, etc. [0003] However, due to the strong hygrosco...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C227/42C07C227/18C07C229/22C07C51/41C07C51/43C07C57/15
CPCC07C51/412C07C51/43C07C227/18C07C227/42C07C229/22C07C57/15
Inventor 龚俊波刘诗苑杜世超曹郓朱培培吴送姑汤伟伟侯宝红
Owner TIANJIN UNIV
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