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Preparation and sensing applications of functionalized three-dimensional graphene composite material

A composite material and functionalization technology, applied in the direction of chemical reaction of materials for analysis, chemiluminescence/bioluminescence, etc., can solve problems such as poor selectivity, achieve low detection limit, rich functional groups and ionic bonds, and improve specificity. Effects of Sexual Recognition

Inactive Publication Date: 2019-04-02
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the chemiluminescent method has a big disadvantage—poor selectivity, because various coexisting substances are likely to cause changes in the intensity of chemiluminescence, and this shortcoming can be overcome by introducing some specific recognition materials, such as molecularly imprinted materials, antigen-antibody materials , aptamer materials, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] (1) Preparation of ionic liquid@graphene: Weigh 0.10 g graphene oxide in 100 mL ultrapure water, sonicate for 15 min until uniform dispersion, then add 0.15 g 1-(3-dimethylaminopropyl) to it -3-Ethylcarbodiimide salt and 0.15 g N-hydroxysuccinimide, sonicated for 20 minutes until uniformly dispersed; then added 0.10 g of ionic liquid to the dispersion, followed by ultrasonication for 25 minutes and magnetic stirring for 25 minutes until mixed homogeneous; the mixture was magnetically stirred in an oil bath at 80°C for 2 h; then centrifuged at 8000 r / min for 8 min, and the supernatant was removed; finally, it was vacuum-dried at 50°C to obtain the ionic liquid@ Graphene;

[0018] (2) Preparation of β-cyclodextrin / ionic liquid@graphene airgel: Weigh 0.25 g ionic liquid@graphene in 50 mL ultrapure water, sonicate for 15 min until uniform dispersion; weigh 0.35 g β- Cyclodextrin and 0.10 g of sodium lauryl sulfate were added to 50 mL of ultrapure water, ultrasonicated for ...

Embodiment 2

[0021](1) Preparation of ionic liquid@graphene: Weigh 0.12 g graphene oxide in 100 mL ultrapure water, sonicate for 20 min until uniform dispersion, then add 0.18 g 1-(3-dimethylaminopropyl) to it -3-Ethylcarbodiimide salt and 0.18 g N-hydroxysuccinimide, sonicate for 25 minutes until uniformly dispersed; then add 0.12 g of ionic liquid to the dispersion, sonicate for 25 minutes and magnetically stir for 25 minutes to mix uniform; the mixture was magnetically stirred in an oil bath at 80°C for 2.5 h; then centrifuged at 8000 r / min for 8 min, and the supernatant was removed; finally, vacuum-dried at 50°C to obtain ionic liquid@ Graphene;

[0022] (2) Preparation of β-cyclodextrin / ionic liquid@graphene airgel: Weigh 0.28 g ionic liquid@graphene in 50 mL ultrapure water, sonicate for 20 min until uniform dispersion; weigh 0.40 g β- Cyclodextrin and 0.12 g of sodium lauryl sulfate were added to 50 mL of ultrapure water, ultrasonicated for 25 min until uniformly dispersed; then th...

Embodiment 3

[0025] (1) Preparation of ionic liquid@graphene: Weigh 0.15 g graphene oxide in 100 mL ultrapure water, sonicate for 20 min until uniform dispersion, then add 0.20 g 1-(3-dimethylaminopropyl) to it -3-Ethylcarbodiimide salt and 0.20 g N-hydroxysuccinimide, sonicated for 30 min until uniformly dispersed; then, 0.15 g of ionic liquid was added to the dispersion, sonicated for 30 min and magnetically stirred for 30 min until mixed homogeneous; the mixture was magnetically stirred in an oil bath at 80°C for 3 h; then centrifuged at 8000 r / min for 8 min, and the supernatant was removed; finally, it was vacuum-dried at 50°C to obtain the ionic liquid@ Graphene;

[0026] (2) Preparation of β-cyclodextrin / ionic liquid@graphene airgel: Weigh 0.30 g ionic liquid@graphene in 50 mL ultrapure water, sonicate for 20 min until uniform dispersion; weigh 0.50 g β- Cyclodextrin and 0.15 g sodium lauryl sulfate were added to 50 mL of ultrapure water, ultrasonicated for 30 min until uniformly di...

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Abstract

The invention discloses preparation of a functionalized three-dimensional graphene composite material and an application technology of the functionalized three-dimensional graphene composite materialin chemiluminescence sensors. The technology is mainly characterized in that a beta-cyclodextrin / ionic liquid@graphene aerogel is prepared, and the surface of the beta-cyclodextrin / ionic liquid@graphene aerogel is modified with an aptamer to obtain a functionalized three-dimensional graphene composite material with high specific recognition ability to streptomycin molecules, wherein the method hascharacteristics of simple preparation process, easily-controlled conditions and low production cost. The present invention further provides a new method for detecting streptomycin. According to the present invention, with the application of the aptamer functionalized beta-cyclodextrin / ionic liquid@graphene aerogel in the chemiluminescence sensor for detecting streptomycin, the advantages of highsensitivity, good selectivity, convenient operation, simple instrument and the like can be achieved; and the functionalized three-dimensional graphene composite material is successfully used in the detection of streptomycin in cucumber samples, has high accuracy and high precision, provides the possibility in actual detection, and has important biological significance in food safety and human health.

Description

technical field [0001] The present invention relates to the preparation of a functionalized three-dimensional graphene composite material and its application technology in chemiluminescent sensors, which belongs to the technical field of photochemical sensors, and specifically relates to aptamer functionalized β-cyclodextrin / ionic liquid@graphite Preparation of ene airgel composite and its application in the detection of streptomycin with chemiluminescence sensor. Background technique [0002] Graphene is a two-dimensional (2D) single-layer carbon material composed of carbon atoms. As a relatively new type of carbon material, graphene is widely used in medicine, sensing, energy storage and other fields. However, due to the van der Waals force between two-dimensional graphene flakes, graphene is prone to aggregation and stacking, which reduces its specific surface area and limits its further applications. In order to further solve this problem, researchers designed and synth...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/28C08J9/36C08L5/16C08L29/04C08K9/04C08K3/04C08K5/00G01N21/76
CPCC08J9/28C08J9/36C08J2201/0484C08J2305/16C08J2329/04C08J2429/04C08K5/00C08K9/04C08K3/042G01N21/76
Inventor 罗川南孙元玲王雪莹林燕娜韩蕊代玉雪孙玮艳朱晓冬刘浩高丹丹
Owner UNIV OF JINAN
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