A kind of gadolinium-based metal fullerene water-soluble nitrene derivative and its preparation method and application

A technology of metallofullerenes and fullerenes, which is applied in the field of carbon nanomaterials, can solve the problems of lack of new paramagnetic gadolinium-based metallofullerene water-soluble derivatives and other problems, and achieve easy large-scale industrial preparation and good smoothness. The effect of magnetic properties and simple purification and separation methods
CN109568607BActive Publication Date: 2021-08-13HENAN AGRICULTURAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HENAN AGRICULTURAL UNIVERSITY
Publication Date
2021-08-13

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Abstract

The invention discloses a water-soluble nitrobene derivative of gadolinium-based metal fullerene, a preparation method and application thereof. The gadolinium-based metal fullerene water-soluble nitrobene derivative is made of paramagnetic gadolinium-based metal fullerene Gd a N b @C 2n with azide N 3 (CH 2 ) m NH 2 or N 3 (CH 2 ) m‑1 COOH is prepared by nitrobin reaction, and its general structural formula is as follows: Gd a N b @C 2n [N(CH 2 ) m NH 2 ] x or Gd a N b @C 2n [N(CH 2 ) m‑ 1 COOM] x In the general structural formula above, a=1~3; b=0~3; n=30~45; m=2~6; x=8~30; M is H, NH 4 , Na or K. The invention provides a method for preparing gadolinium-based metal fullerene water-soluble nitrene derivatives through nitrene reaction. The gadolinium-based metallofullerene water-soluble nitrene derivatives have good water solubility and good paramagnetic properties, and can be used as magnetic resonance imaging contrast agents. When used in MRI imaging, the contrast enhancement effect is very significant. Medical diagnosis and treatment, especially in MRI image-guided diagnosis and treatment, has an important application prospect.
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Description

technical field

[0001] The invention belongs to the field of carbon nanomaterials, and relates to a class of paramagnetic gadolinium-based metal fullerene water-soluble nitrene derivatives and a preparation method and application thereof. The gadolinium-based metal fullerene water-soluble nitrene derivatives can be used as Magnetic resonance imaging (MRI) contrast agents. Background technique

[0002] have a high longitudinal relaxation rate (R 1 ), paramagnetic metallofullerenes with low biotoxicity T 1 Type MRI contrast agents have been developed for nearly 20 years. Among them, gadolinium-based metal fullerene MRI contrast agents as molecular imaging probes are most commonly reported in the literature. These MRI probes are Gd@C modified by hydroxylation, amination, Bingel-Hirsch or Prato reactions in one or more steps. 60 、Gd@C 82 、Sc x Gd 3-x N@C 80 、Gd 3 N@C 80 、Gd 3 N@C 84 derivative. Among these derivatives, Gd@C 82 (OH) 40 Labeling cells as molecular p...

Claims

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