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Preparation method of huperzine A molecularly imprinted hydrogel microspheres

A technology of hydrogel microspheres and huperzine A is applied in the directions of medical preparations with non-active ingredients, medical preparations containing active ingredients, and capsule delivery, which can solve the problems of low feasibility and achieve high drug loading. The effect of improving the biocompatibility and reducing the difficulty of elution

Active Publication Date: 2019-04-23
FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is only one literature on the preparation of huperzine A molecularly imprinted polymers at home and abroad (Li Zhiping, "Preparation, Characterization and Adsorption Properties of Huperzine A Imprinted Polymers", 2013), the prepared The huperzine A molecularly imprinted hydrogel microspheres are a new type of adsorption material with high efficiency separation and enrichment developed with methacrylic acid as the raw material and silica gel as the sacrificial carrier. However, if it is applied to pharmaceutical dosage forms, the feasibility lower

Method used

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  • Preparation method of huperzine A molecularly imprinted hydrogel microspheres
  • Preparation method of huperzine A molecularly imprinted hydrogel microspheres
  • Preparation method of huperzine A molecularly imprinted hydrogel microspheres

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Embodiment

[0026] 1) Preparation of HPMC-huperzine A aqueous solution: take 0.4 g of HPMC and stir in 30 mL of 50 ℃ ultrapure water, let it cool, add 24 mg of huperzine A, and pre-polymerize with ultrasound for 30 min to obtain HPMC-huperzine Aqueous solution of phenidine A, for subsequent use;

[0027] 2) Preparation of compound dispersant: Mix 0.04 g Tween-80 and 0.4 g Span-80, add to 180 mL cyclohexane, and disperse evenly to obtain a compound dispersant;

[0028] 3) Preparation of huperzine A molecularly imprinted polymer: take 180 mL of compound dispersant, slowly add 30 mL of HPMC-huperzine A aqueous solution at a stirring speed of 460-720 r / min, stir for 3 hours to make it uniformly dispersed Add 40 mg TEMED and 6 mL DVS solution with a volume concentration of 1%, continue to stir until fully cross-linked, wash the product, freeze-dry and place the obtained polymer in an Erlenmeyer flask, add 50 mL methanol for ultrasonic extraction for 30 min, and discard The extraction solvent ...

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Abstract

The invention discloses a preparation method of huperzine A molecularly imprinted hydrogel microspheres. According to the method, huperzine A serves as template molecules, HPMC is a functional monomer, TEMED serves as a catalyst, DVS serves as a cross-linking agent, and a reverse suspension polymerization method is utilized to prepare the huperzine A molecularly imprinted hydrogel microspheres. The huperzine A molecularly imprinted hydrogel microspheres have relatively high specificity recognition capability, have a slow release function, are suitable for oral administration, and are a novel pharmaceutical preparation.

Description

technical field [0001] The invention belongs to the field of preparation of pharmaceutical dosage forms, and mainly relates to a carrier preparation of huperzine A, more specifically, relates to a preparation method of huperzine A molecularly imprinted hydrogel microspheres. Background technique [0002] Huperzine A (Huperzine A, HupA) is a central acetylcholinesterase (acetylcholinesterase, AChE) inhibitor isolated from the folk herb Huperzine serrata, which exhibits extensive neuroprotection and anti-oxidative stress, and has the ability to improve brain damage. It has been widely used in the treatment of neurodegenerative diseases such as Alzheimer's disease (AD), vascular dementia (VD) and mental retardation. Clinical data show that the overall clinical safety of huperzine A is good, there is no dose-limiting liver toxicity, and there is no abnormality in cardiovascular clinical data, but a small number of patients will experience mild to moderate gastrointestinal sympto...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/38A61K31/4748A61P25/28
CPCA61K9/5047A61K9/5089A61K31/4748A61P25/28
Inventor 余宇燕高璇张红艳宋煜张淑玲
Owner FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE