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A preparation method of polylactic acid/polyglycolic acid drug-loaded microspheres with controllable drug release

A technology of polyglycolic acid and drug-loaded microspheres, which is applied in the fields of biomedicine and polymer chemistry, can solve the problems of short maintenance of therapeutic levels, achieve the effects of high drug purity, advanced technology, and ease the phenomenon of burst release

Active Publication Date: 2021-03-16
TAIYUAN UNIV OF TECH
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  • Description
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  • Application Information

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Problems solved by technology

[0003] In the traditional uncontrolled release of drug administration, the drug concentration suddenly rises in a certain period of time during the administration process, which makes the drug potentially toxic, and the therapeutic level of the drug is maintained for a short time, and the drug can only be released by the next administration. Concentrations reaching therapeutic levels

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  • A preparation method of polylactic acid/polyglycolic acid drug-loaded microspheres with controllable drug release
  • A preparation method of polylactic acid/polyglycolic acid drug-loaded microspheres with controllable drug release
  • A preparation method of polylactic acid/polyglycolic acid drug-loaded microspheres with controllable drug release

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Embodiment Construction

[0053] The present invention will be further described below in conjunction with accompanying drawing:

[0054] figure 1 As shown, the state diagram for the preparation of drug-loaded microspheres, the position and connection relationship of each component must be correct, and the operations should be performed in sequence.

[0055] The water bath 1 is rectangular, the upper part of the water bath 1 is a three-necked flask 2, and the lower part is an electric heater 11; There are water inlet 6, water outlet 7, and gas outlet 8: the three-neck flask 2 contains a reaction solution 18, and a magnetic stirrer 9 is placed at the inner bottom; a display screen 12, an indicator light 13, and a power switch are arranged on the electric heater 11 14. Timing controller 15, agitator controller 16, electric heater controller 17.

[0056] figure 2 Shown is the comparison of the drug-loaded microspheres and the drug-loaded microspheres after drug release. The polylactic acid / polyglycoli...

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Abstract

The invention relates to a method for preparing polylactic acid / polyglycolic acid drug-loaded microspheres with controllable drug release. For a case of a low drug release efficiency, polylactic acid,polyglycolic acid, tea polyphenol, dichloromethane, gelatin polysorbate / 80 and deionized water are used as raw materials, a solution is prepared, the drug-loaded microspheres are prepared, suction filtering and vacuum drying are conducted to prepare the polylactic acid / polyglycolic acid drug-loaded microspheres with the controllable drug release, the degradation of drugs is effectively controlled, the phenomenon of sudden release of the drugs is relieved, the action and utilization of the drugs are effectively prolonged, and the method is advanced in process, accurate and detailed in data andhigh-purity in the prepared drugs and is an advanced preparation method for a drug slow release agent.

Description

Technical field: [0001] The invention relates to a preparation method of polylactic acid / polyglycolic acid drug-loaded microspheres, which belongs to the technical field of biomedicine and also belongs to the field of polymer chemistry. Background technique: [0002] Drug-loaded microspheres refer to skeleton-type micro-spherical entities made by dissolving or dispersing drugs in sphere-forming materials, which can release drugs slowly or controlledly, so that drugs can be concentrated in the target area; drug-loaded microspheres are used as drug delivery carriers, It has obvious advantages in improving drug stability and bioavailability, especially in drug sustained and controlled release and targeted drug delivery, and these advantages depend to a large extent on the choice of carrier materials; the carrier materials used in the preparation of drug-loaded microspheres Among them, biodegradable synthetic polymer materials have received widespread attention and been widely u...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/58A61K47/34A61K36/82A61K31/353
CPCA61K9/5031A61K31/353A61K36/82
Inventor 刘淑强吴改红张瑶刘明芳王鹏张洁李甫张曼
Owner TAIYUAN UNIV OF TECH
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