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Drug-loaded elastomeric wound dressing containing halloysite nanotubes and preparation method thereof

A technology of halloysite nanotubes and wound dressings, which is applied in medical science, bandages, absorbent pads, etc., and can solve problems such as secondary trauma and bacterial infection

Active Publication Date: 2017-10-31
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, when it is used, the wound granulation tissue grows into the dressing and causes adhesion; when it is removed, it is easy to cause secondary trauma; it is easy to cause bacterial infection due to wound area fluid

Method used

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  • Drug-loaded elastomeric wound dressing containing halloysite nanotubes and preparation method thereof
  • Drug-loaded elastomeric wound dressing containing halloysite nanotubes and preparation method thereof
  • Drug-loaded elastomeric wound dressing containing halloysite nanotubes and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0038] Example 1: 100:50:5:1

[0039] (1) Add 32.05g of gelatin and 16.03g of water into a reaction flask, stir and put it into a vacuum oven at a temperature of 70°C. After 7 days of reaction, take it out to obtain the desired uniform elastomer raw rubber.

[0040] (2) Weigh 2g of halloysite nanotubes into a three-necked flask and add 20ml of toluene reagent, fill the three-necked flask with nitrogen, set the temperature of the oil bath to 120°C, and after the temperature rises to 120°C, pour the Continue to add 4ml of 3-aminopropyltriethoxysilane to carry out the modification reaction, and take out the toluene solution of halloysite nanotubes after 24 hours of reaction. The toluene solution containing the halloysite nanotubes is centrifuged for 5 times, and the modified halloysite nanotubes are dried and ground.

[0041] (3) Weigh 2 g of the antibacterial drug polymyxin B sulfate and add it into deionized water, stir well to dissolve it and obtain a saturated solution of po...

example 2

[0045] Example 2:100:1000:50:50

[0046] (1) Add 4.17g of gelatin and 41.67g of glycerol into the reaction flask, stir and put it into a vacuum oven with the temperature set at 50°C. After 2 days of reaction, take out the desired uniform elastomer raw rubber.

[0047] (2) Weigh 2.5g of halloysite nanotubes into a three-necked flask and add 30ml of toluene reagent, fill the three-necked flask with nitrogen, set the temperature of the oil bath to 120°C, and after the temperature rises to 120°C, pour the three-necked flask Continue to add 5ml of 3-aminopropyltriethoxysilane to carry out the modification reaction, and take out the toluene solution of halloysite nanotubes after 24 hours of reaction. The toluene solution containing the halloysite nanotubes is centrifuged for 5 times, and the modified halloysite nanotubes are dried and ground.

[0048] (3) Weigh 2.5 g of the antibacterial drug cephalosporin and add it into deionized water, stir well to dissolve it and obtain a satur...

example 3

[0052] Example 3: 100:100:15:10

[0053] (1) Add 22.22g of sodium alginate, 11.11g of glycerin and 11.11g of deionized water into the reaction flask, stir and put it into a vacuum oven with the temperature set at 60°C. After 5 days of reaction, take it out to get the desired homogeneous elastic rubber.

[0054] (2) Weigh 4g of halloysite nanotubes into a three-necked flask and add 40ml of toluene reagent, fill the three-necked flask with nitrogen, set the temperature of the oil bath to 120°C, and after the temperature rises to 120°C, pour the Continue to add 8ml of 3-aminopropyltriethoxysilane to carry out the modification reaction, and take out the toluene solution of halloysite nanotubes after 24 hours of reaction. The toluene solution containing the halloysite nanotubes is centrifuged for 5 times, and the modified halloysite nanotubes are dried and ground.

[0055] (3) Weigh 4 g of the antibacterial drug tetracycline hydrochloride and add it into deionized water, stir wel...

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Abstract

The invention relates to a drug-loaded elastic body wound dressing containing halloysite nanotubes and a preparation method thereof. It is based on a degradable natural polymer, adding antibacterial drugs and halloysite nanotubes loaded with antibacterial drugs, and preparing elastomeric biofilms with different biological activities by hot melt blending. The material of the invention is cheap, has excellent biological properties and degradability, and can also promote tissue regeneration and repair, drug release can also inhibit bacterial infection and inflammation that are prone to occur, and can be widely used in tissue engineering scaffolds, artificial organs, Medical and health fields such as wound dressings, drug release films, blood storage bags, and medical catheters.

Description

Technical field: [0001] The invention belongs to the field of biopolymer materials, and in particular relates to a wound dressing elastomer biofilm which uses a degradable natural polymer material as a matrix material and adds antibacterial drugs and halloysite nanotubes loaded with antibacterial drugs and a preparation method thereof . Background technique: [0002] The skin is a barrier to contact with the external environment, and it is easy to be injured or have skin defects due to diseases, which will lead to the loss of moisture, electrolytes and proteins in the wound, and the open wound also increases the chance of infection. [0003] In order to alleviate the occurrence of the above symptoms, dressings are generally used to cover and protect the wound and provide an environment conducive to wound healing. For quite a long time, the most common surgical wound dressings were medical absorbent cotton and gauze. It can play a certain role in promoting the treatment of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/20A61L15/22A61L15/32A61L15/28A61L15/44
Inventor 张立群牛玉昭薛佳佳廖美红
Owner BEIJING UNIV OF CHEM TECH
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