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Radionuclide pollution decontamination agent and preparation method and application thereof

A radionuclide and decontamination technology, applied in the field of medicine, can solve the problem of low decontamination efficiency of radioactive wounds or can only target certain elements, achieve good healing function, reduce absorption, and improve decontamination ability. Effect

Active Publication Date: 2019-05-03
中国人民解放军海军特色医学中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these methods have low decontamination efficiency for radioactive wounds or can only target some specific elements. Therefore, it is of great significance to develop broad-spectrum and high-efficiency decontamination agents that can be applied to radioactively contaminated wounds.

Method used

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  • Radionuclide pollution decontamination agent and preparation method and application thereof
  • Radionuclide pollution decontamination agent and preparation method and application thereof
  • Radionuclide pollution decontamination agent and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The formulation optimization of embodiment 1 radioactive pollution decontamination agent

[0029] 1. Reagents and animals

[0030] Disodium ethylenediaminetetraacetic acid (EDTA·Na 2 ), chloral hydrate, sodium alginate, carboxymethyl chitosan, lidocaine hydrochloride, cesium chloride, SD rats.

[0031] 2. Experimental method

[0032] 1. Determination of decontamination efficiency

[0033] Before the experiment, the rats were anesthetized by intraperitoneal injection of 10% chloral hydrate (0.3ml / 100g), and the hair on both sides of the back spine was removed with a shaver, and four holes were symmetrically prepared on the skin on both sides of the spine with a 1cm diameter punch. Wound, the wound is deep to the fascia layer. Infection was started immediately after the wound model was made. Take 100μl of 1000mg / L Cs +The aqueous solution is evenly applied to the wound area as a poisoning solution, and after standing for 5 minutes, take 50ml of decontamination agent...

Embodiment 2

[0047] The preparation of embodiment 2 radioactive contamination wound decontamination agent

[0048] According to the recipe: EDTA·Na 2 : 20%, carboxymethyl chitosan: 0.1%, sodium alginate: 0.2%, lidocaine hydrochloride: 1.0%, accurately weigh each component, and accurately weigh 20% of EDTA·Na 2 Add in pure water, heat in a water bath and add sodium hydroxide to adjust the pH to completely dissolve, accurately weigh 0.1% carboxymethyl chitosan and 0.2% sodium alginate, add pure water and stir to dissolve, then add EDTA Na 2 After mixing the aqueous solution, add 1% lidocaine aqueous solution, and adjust the pH of the mixed solution to 6.9 with hydrochloric acid to obtain a decontamination agent.

Embodiment 3

[0050] Determination of Decontamination Efficiency of Radioactively Contaminated Wound Decontamination Agents on Wounds Contaminated by Different Nuclides

[0051] Before the experiment, the rats were anesthetized by intraperitoneal injection of 10% chloral hydrate (0.3ml / 100g), and the hair on both sides of the back spine was removed with a shaver, and four holes were symmetrically prepared on the skin on both sides of the spine with a 1cm diameter punch. Wound, the wound is deep to the fascia layer. Infection was started immediately after the wound model was made. After preparing the wound for defecation, take 100 μL of the poisoned solution and apply it evenly on the wound area. The poisoned solution is Co 2+ , Mn 2+ 、Sr 2+ 、Ni 2+ 、Cs + The aqueous solution with a concentration of 1000mg / L, let it stand for 5min, take 50ml of the decontaminant prepared in Example 2, and use a disposable wound pulse flushing system to flush the poisoned wound once, with a flow rate of 1...

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Abstract

The invention relates to a radionuclide pollution decontamination agent and a preparation method and an application thereof. The decontaminant comprises the following components by mass percentage: 1.0%-20% of EDTA.Na2, 0.1%-0.4% of carboxymethyl chitosan, 0.05%-0.3% of sodium alginate, 0.5%-2.0% of lidocaine hydrochloride, and balance of pure water or phosphate buffer, wherein a pH value is 6.9-7.0. The preparation method comprises the following steps: EDTA-Na2, carboxymethyl chitosan, sodium alginate and lidocaine hydrochloride are accurately weighed according to the proportion, the EDTA-Na2is heated and dissolved under alkaline conditions, and then the carboxymethyl chitosan and sodium alginate are dissolved, and then the two are mixed and stirred uniformly, a lidocaine hydrochloride solution is added, the pH is adjusted to 6.7-6.9 with HCl, the material is dissolved while stirring, and metering a volume. The decontamination agent has a chelate adsorption function on a plurality ofradionuclides, has no toxic and side effects, and can be used as the low-toxic and high-efficiency radionuclide pollution decontamination agent.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a radionuclide pollution decontamination agent and its preparation method and application. Background technique [0002] Radioactive pollution refers to the occurrence of radioactive substances or rays that exceed national standards on the surface or inside of materials, human bodies, and environmental media in places due to human activities. With the rapid development of science and technology and economy, nuclear energy is widely used in energy, military, medical, testing and other fields. When people are engaged in various nuclear-related practical activities, wounds such as cuts, stab wounds, explosion injuries, burns and scalds may occur. Various body surface wounds are in a radioactively polluted environment, and wounds may be contaminated by radioactivity. After the radioactive material enters the human body through the wound, it will transfer to tissues such as blood, mus...

Claims

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Application Information

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IPC IPC(8): A61K31/734A61K9/08A61P39/02A61P17/02A61K31/167A61K31/198A61K31/722
Inventor 罗群何颖胡秀婷
Owner 中国人民解放军海军特色医学中心
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