Preparation method of tricyclic EGFR kinase inhibitor

Abstract

The invention belongs to the field of pharmaceutical chemistry, and relates to a preparation method of a tricyclic EGFR kinase inhibitor, and specifically relates to a preparation method of a compoundof formula i or a pharmaceutically acceptable salt, a crystal, a hydrate or a solvate thereof. The preparation method of the compound of formula i or the pharmaceutically acceptable salt, the crystal, the hydrate or the solvate thereof has relatively high yield and purity, the reaction conditions are mild, the purification is easy, the process is stable, the operation is easy, the environment friendly effect is achieved, and the industrial scale production and application can be met.

Description

technical field [0001] The invention belongs to the field of medicinal chemistry, in particular to N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(6,7 ,8,9-tetrahydropyrido[1,2-a]indol-10-yl)pyrimidin-2-yl)amino)phenyl)acrylamide or its pharmaceutically acceptable salt, crystal, hydrate or Preparation of solvates. Background technique [0002] Epidermal growth factor receptor (EGFR) is a transmembrane protein tyrosine kinase member of the erbB receptor family. Homodimerization and / or heterodimerization of the erbB receptor leads to phosphorylation of key tyrosine residues in the intracellular domain, stimulating many intracellular signaling pathways involved in cell proliferation and survival. Dysregulation of erbB family signaling promotes proliferation, invasion, metastasis, angiogenesis, and tumor cell survival, and has been described in many cancers, such as lung, head and neck, and breast cancers, among others. Small-molecule EGFR tyrosine kinase inhibi...

AI Technical Summary

Problems solved by technology

There is no disclosure of a preparation method suitable for industrial production of the compound of formula I or its pharmaceutically acceptable salt, crystal, hydrate or solvate at present in the art. The preparation method of crystallization, hydrate or solvate is researched to obtain the preparation formula I compound or its pharmaceutically acceptable salt, crystallization, hydration method of substance or solvate

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