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Omeprazole aerosol and preparation method thereof

A technology of omeprazole gas and omeprazole, which is applied in the field of pharmaceutical preparations, can solve problems such as insufficient acid resistance and stability, susceptibility to gastrointestinal damage, and poor stability, so as to achieve good compliance and avoid liver headaches. overeffect, effect of avoiding destruction

Inactive Publication Date: 2019-05-17
ZHENGZHOU TAIFENG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Poor stability, easy to change color in long-term storage, and easy to be damaged by gastrointestinal tract after oral administration
In view of the problems of insufficient acid resistance and insufficient stability in the prior art preparations, the present invention provides a novel aerosol containing omeprazole by studying the prescription and process of the aerosol containing omeprazole

Method used

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  • Omeprazole aerosol and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

720g

[0021] Preparation:

[0022] Weigh 50g of omeprazole, 200g of absolute ethanol, 10g of Tween 80, and 20g of polyethylene glycol 300 in the prescribed amount, stir and dissolve the absolute ethanol, Tween 80, and polyethylene glycol 300, and then add Omeprazole Azole, fully stirred to form a transparent solution, filtered, poured into a vacuumized aluminum tank according to the specified filling volume, equipped with a quantitative valve, sealed, and finally poured into tetrafluoroethane to obtain the finished product. 10ml per bottle, 100 bottles in total, 100ul per press.

Embodiment 2

720g

[0025] Preparation:

[0026] Weigh 50g of omeprazole, 200g of propylene glycol, 10g of poloxamer, and 20g of sodium metabisulfite in the prescribed amount, stir and dissolve the propylene glycol, poloxamer, and sodium metabisulfite, then add omeprazole, stir well, and become transparent The solution is filtered, poured into a vacuumized aluminum tank according to the specified filling volume, equipped with a quantitative valve, sealed, and finally filled with heptafluoropropane to obtain the finished product. 10ml per bottle, 100 bottles in total, 100ul per press.

Embodiment 3

720g

[0029] Preparation:

[0030] Weigh 50g of omeprazole, 200g of glycerin, 10g of sodium lauryl sulfate, and 20g of vitamin E in the prescribed amount, stir and dissolve glycerin, sodium lauryl sulfate, and vitamin E, then add omeprazole, and stir well , into a transparent solution, filtered, poured into a vacuumized aluminum tank according to the specified filling volume, equipped with a quantitative valve, sealed, and finally poured into dimethyl ether to obtain the finished product. 10ml per bottle, 100 bottles in total, 50ul per press.

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PUM

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Abstract

The invention belongs to the technical field of medicine, and discloses an omeprazole aerosol and a preparation method thereof. The omeprazole aerosol is composed of an active component omeprazole, alatent solvent, a surfactant, a propellant and an antioxidant. The active ingredients in the preparation can be inhaled into a lung through a nasal cavity or oral cavity, can be quickly absorbed and take effect quickly, and can effectively avoid the destruction of the main component omeprazole in gastrointestinal tracts and the first-pass effect of liver; the omeprazole aerosol has the advantagesof high bioavailability, good compliance, and convenient carrying and use, and is suitable for industrialized production.

Description

technical field [0001] The invention relates to an omeprazole aerosol and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] The formation of gastric ulcer and duodenal ulcer is related to the digestion of gastric acid and pepsin, so it is called peptic ulcer. About 10% of the population may suffer from this disease in their lifetime, so it is a frequently-occurring and common disease and plays an important role in the Department of Gastroenterology. The etiology of gastric ulcer and duodenal ulcer is complex, including genetic factors, chemical factors, life factors, mental factors, infection factors, etc. They are common in people with irregular diet, high work pressure, and mental stress. In addition, long-term smoking and drinking are also huge incentives . Most patients with gastric ulcer and duodenal ulcer have recurrent attacks, and the attack period and remission period alternate with changes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/72A61K9/12A61K31/4439A61P1/04
Inventor 沙薇黄普广李婷
Owner ZHENGZHOU TAIFENG PHARMA CO LTD