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Application of propylene glycol to medicine for preventing intestinal type radiation disease and radiation enteritis

A technology of radiation enteritis and propylene glycol, which is applied in the field of medicine and can solve problems such as propylene glycol that have not yet been seen

Inactive Publication Date: 2019-05-28
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, there are no reports of propylene glycol being used to prevent gastrointestinal tissue damage caused by ionizing radiation or radiation enteritis caused by tumor radiotherapy

Method used

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  • Application of propylene glycol to medicine for preventing intestinal type radiation disease and radiation enteritis
  • Application of propylene glycol to medicine for preventing intestinal type radiation disease and radiation enteritis
  • Application of propylene glycol to medicine for preventing intestinal type radiation disease and radiation enteritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1. In vitro experiments showed that in vitro incubation with propylene glycol significantly reduced the apoptosis of rat intestinal crypt epithelial cells IEC-6 induced by γ-ray irradiation

[0033] We studied the effect of 1,2-propanediol and its isomer 1,3-propanediol, and preliminarily observed that alcohol compounds can reduce the radiation of epithelial cells by X-ray irradiation of rat intestinal crypt epithelial cells IEC-6. damage. IEC-6 cells were pretreated with 2% volume concentration of propylene glycol for 30 min, the IR group was given the same volume of normal saline, irradiated with 15.0 Gy (1.325 Gy / min) X-rays and replaced the complete medium for 48 h after irradiation, and passed through the flow The apoptosis rate of cells in each group was detected by cytometer, and the results were as follows: figure 1 As shown, propylene glycol pretreatment can significantly reduce the apoptosis rate of IEC-6 cells induced by radiation, and the early apop...

Embodiment 2

[0034] Example 2. Preventing intraperitoneal injection of 1,2-propanediol from reducing radiation damage to intestinal crypts in mice

[0035] In order to further prove the preventive effect of propylene glycol on intestinal radiation injury, we conducted research on intestinal type acute radiation sickness mouse model through BrdU incorporation experiment. BrdU is an analogue of thymidine, which can be incorporated into the DNA synthesized by cells like thymidine. By detecting the expression level of BrdU in mice receiving BrdU infusion, it can reflect the state of cell proliferation.

[0036] C 57 BL6 / J mice were divided into solvent control group (IR) and propylene glycol administration groups at different times. The propylene glycol administration groups were treated before (-) 12h, 6h, 3h, 1h and after (+) 15Gy X-ray whole body irradiation. 1 hour of intraperitoneal injection of 1,2-propanediol 6g / kg, the solvent control group was given an equal volume of normal saline 1...

Embodiment 3

[0037] Example 3, prevention of intraperitoneal injection of 1,2-propanediol significantly improves the survival rate of mice with intestinal type acute radiation sickness

[0038] We firstly irradiated the abdomen with X-ray 16.0Gy C 57 Observation of the protective effect of prophylactic administration of 1,2-propanediol in BL / 6J mice simulated intestinal injury model induced by radiotherapy, healthy C 57 BL / 6J mice were intraperitoneally injected with 1,2-propanediol 6g / kg or the same volume of normal saline (IR) 1 hour before irradiation, 8 mice in each group, and then all received 16.0Gy (1.325Gy / min) X-ray local irradiation in the abdominal cavity, and observed The 30-day survival rate of the mice was recorded and the body weight was recorded, and the results were as follows: image 3As shown, all the mice in the normal saline administration group died 5 days after irradiation, and the 30-day survival rate of the mice in the 1,2-propanediol prevention administration gro...

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Abstract

The invention provides application of propylene glycol to medicine for preventing intestinal type radiation disease and radiation enteritis. According to the application disclosed by the invention, the propylene glycol is firstly applied to the field of radiation protection research, and the research proves that compared with former prevention application, the propylene glycol has an obvious experimental therapeutic effect on acute radiation injury of intestinal tracts and has curative effects on intraperitoneal injection and oral administration; moreover, a radiation protection mechanism of the propylene glycol is possibly related with removal of hydroxyl radicals through the propylene glycol and alleviation of intestinal cell DNA injuries. At present, the phenomenon that gastrointestinaltissue injuries or the radiation enteritis occurs when the propylene glycol is applied to prevention of ionizing radiation or tumor radiotherapy is not reported yet.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a method for preventing gastrointestinal tissue damage caused by ionizing radiation with propylene glycol. Specifically, the present invention relates to the use of propylene glycol, alone or in combination with other treatments, for the prevention of intestinal radiation sickness and radiation enteritis induced by tumor radiation therapy. Background technique [0002] Nuclear secondary disasters (nuclear power plants, drilling accidents), nuclear-related terrorist attacks, accidental radioactive nuclear accidents, and medical exposure to tumors may all lead to acute radiation sickness (Acute Radiation Sickness, ARS). Acute radiation sickness is a systemic disease. Depending on the exposure dose, the main damaged organs are different. When the body is exposed to radiation greater than 10Gy once or within a short period of time (several days), the intestinal damage is...

Claims

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Application Information

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IPC IPC(8): A61K31/047A61P1/00
CPCA61K31/047A61P1/00
Inventor 余祖胤申星邢爽熊国林
Owner ACADEMY OF MILITARY MEDICAL SCI
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