A kind of plant hollow capsule and preparation method thereof

A plant hollow capsule and gel technology, which is applied in the directions of capsule delivery, pharmaceutical formulations, and inactive medical preparations, can solve the problems of inconsistency in friability and disintegration time, and avoid drying water loss and absorption. The effect of high tide, high medication compliance, and not easy to deform

Active Publication Date: 2021-03-09
CHONGQING HENGSHENG MEDICINAL CAPSULE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved by the present invention is to provide a method for preparing vegetable-based hollow capsules by modifying and preparing hypromellose, and then collating related ingredients to improve the tightness of the hollow capsules. Performance, and solve the problem of inconsistent friability and disintegration time limit

Method used

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  • A kind of plant hollow capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) Add 1 kg of microcrystalline cellulose to 100 kg of hypromellose and mix well to obtain modified hypromellose.

[0037] (2) Add 25kg of modified hypromellose to 57.5kg of purified water to disperse. The temperature of the purified water is 85°C when adding, and keep it under constant stirring for 30 minutes to obtain a cellulose solution.

[0038] (3) Take 237.5 g of gellan gum and add it to 63.75 kg of purified water to stir and swell. The temperature of the purified water is 17°C when adding, then heat to 90°C and keep it for 45 minutes to obtain gellan gum swelling liquid.

[0039] (4) Add the gellan gum swelling solution to the cellulose solution at a temperature 3°C higher than that of the cellulose solution, stir for 8 minutes, and mix evenly; cool to 60°C to obtain a cellulose gel solution.

[0040] (5) Add 125g of potassium citrate to 3.75kg of purified water and stir to dissolve. The temperature of the purified water is 50°C when adding, then add to the cellu...

Embodiment 2

[0045] (1) Add 5kgkg of microcrystalline cellulose to 100kg of hypromellose and mix well to obtain modified hypromellose.

[0046] (2) Add 100 kg of modified hypromellose to 245 kg of purified water to disperse. The temperature of the purified water is 87° C. when adding, keep stirring for 40 minutes to obtain a cellulose solution.

[0047] (3) Add 900 g of gellan gum to 235 kg of purified water and stir to swell. The temperature of the purified water is 17°C when adding, and then heated to 90°C and kept for 50 minutes to obtain gellan gum swelling liquid.

[0048] (4) Add the gellan gum swelling solution to the cellulose solution at a temperature 3°C higher than the temperature of the cellulose solution, and pour the cellulose solution and the gel swelling solution into the cellulose solution at the same time at a speed of 0.5kg / s. Mix in the kettle and start stirring when pouring, and continue stirring for 9 minutes after pouring, mix well, and then cool to 63°C to obtain a ...

Embodiment 3

[0054] (1) Add 8 kg of microcrystalline cellulose to 100 kg of hypromellose and mix well to obtain modified hypromellose.

[0055] (2) Add 100 kg of modified hypromellose to 250 kg of purified water to disperse. The temperature of the purified water is 90° C. when adding, keep stirring for 45 minutes to obtain a cellulose solution.

[0056] (3) Add 950 g of gellan gum to 240 kg of purified water and stir to swell. The temperature of the purified water is 20°C when adding, and then heated to 95°C and kept for 60 minutes to obtain gellan gum swelling liquid.

[0057] (4) Add the gellan gum swelling solution to the cellulose solution at a temperature 4°C higher than the temperature of the cellulose solution, and pour the cellulose solution and the gel swelling solution into the cellulose solution at the same time at a speed of 1.0kg / s. Mix in the kettle and start stirring when pouring, and continue stirring for 10 minutes after pouring, mix well, and then cool to 65°C to obtain a...

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Abstract

A plant hollow capsule and a preparation method thereof, belonging to the field of hollow capsule production technology, which is prepared from modified hypromellose, a gelling agent, a coagulant aid, a plasticizer, a surfactant and a balance of water; Among them, modified hypromellose is formed by adding an appropriate amount of microcrystalline cellulose into hypromellose; its beneficial effect is that in addition to maintaining the moldability of hypromellose glue, it can make capsules It has a certain degree of moisture retention, and avoids drying, water loss and moisture absorption during storage, thereby avoiding shrinkage or expansion of the capsule shell, effectively avoiding powder leakage, and can also speed up the disintegration speed of the capsule; adding plasticizer properly can improve The ductility and plasticity of the capsule, combined with a gelling agent can ensure uniform thickness of the capsule wall; appropriate addition of surfactants combined with microcrystalline cellulose can speed up the disintegration speed; appropriate addition of gelling agents and coagulation aids combined with plasticizers can effectively improve Friability.

Description

technical field [0001] The invention belongs to the technical field of hollow capsule production, in particular to a plant hollow capsule prepared from hypromellose as a raw material. Background technique [0002] In the century-old history of capsules, gelatin has always maintained its position as the mainstream capsule material due to its wide range of sources, stable physical and chemical properties, and excellent processing performance. With the increase of people's preference for capsules, hollow capsules are more widely used in the fields of food, medicine and health care products. [0003] Although gelatin capsules have been widely used, there are some insurmountable problems in gelatin capsules. For example, the main component of gelatin hollow capsules is protein, which is easy to breed and reproduce bacteria and microorganisms. Preservatives and antibacterial agents need to be added during the production process, and ethylene oxide must be used to sterilize the fi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/38
Inventor 李全忠吴易果华玉容唐杰胡晓涛
Owner CHONGQING HENGSHENG MEDICINAL CAPSULE
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