Unlock instant, AI-driven research and patent intelligence for your innovation.

Polymeric sorbent for removal of impurities from whole blood and blood products

A technology for blood products and polymers, applied in the fields of blood diseases, selective adsorption, alkali metal compounds, etc., can solve problems such as increased risk of death

Pending Publication Date: 2019-06-07
CYTOSORBENTS CORP
View PDF16 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In one of these studies, the risk of in-hospital death increased by 2% for each day of ageing of packed red blood cell units

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Polymeric sorbent for removal of impurities from whole blood and blood products
  • Polymeric sorbent for removal of impurities from whole blood and blood products
  • Polymeric sorbent for removal of impurities from whole blood and blood products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1 Adsorbent 1~11 is synthesized

[0044] The reactor was set up such that the kettle (0.5 L) was equipped with an over head stirrer, multi-level stirrer blades, water cooled condenser, thermocouple and bubbler. Install the gasket between the top cover and bottom kettle. Plug all unused ports with appropriate plugs. The temperature was controlled with a heating mantle regulated by a temperature controller equipped with the above-mentioned thermocouples.

[0045] Polymerization, polyvinyl alcohol was dispersed in a water load at room temperature (RT), followed by heating to 70°C. The remaining salts (see Table 1, MSP, DSP, TSP & Sodium Nitrite) were then dissolved in the water load. The PVA and salt solution was heated to 80°C and stirred. The premixed organic phase listed in Table 2 including the initiator was poured onto the aqueous phase in the reactor and the stirring speed set in rpm for proper droplet size formation. Once the temperature reached a ...

Embodiment 2

[0050] Embodiment 2 hole structure characteristic

[0051] The pore structure of the adsorbent polymers was analyzed with a granulometry AutoPore IV 9500 VI.09 Mercury Penetrometer (Hg Intrusion Instruments). The result is as figure 1 , where pore volume is plotted as a function of pore diameter.

Embodiment 3

[0052] The comparison of embodiment 3 pore structure and biomolecule adsorption

[0053] The pore structure of the adsorbent polymer was compared with cytochrome c, human serum albumin and immunoglobulin G (IgG). Cytochrome C (~12 kilodaltons) is used as a surrogate for intermediate molecular weight proteins such as cytokines, human serum albumin (67 kilodaltons) is used as a surrogate for hemoglobin (64 kilodaltons), and IgG stands for antibody. The comparison is shown in Table 3.

[0054] table 3

[0055]

[0056]

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
diameteraaaaaaaaaa
Login to View More

Abstract

Methods of treating blood, blood products or physiologic fluid maximize shelf life and / or minimize transfusion related complications such as non-hemolytic transfusion reactions such as fever, transfusion-related acute lung injury (TRALI), transfusion associated dyspnea (TAD), and allergic reactions by removing undesirable molecules in the blood, blood product or physiologic fluid milieu through use of a sorbent. The blood purification devices comprise: (a) a compliant container suitable for the storage of blood, blood product or physiologic fluid; (b) sorbent comprising hemocompatible materialsuitable for treating blood, blood product or physiologic fluid, where the sorbent is contained within the compliant container.

Description

[0001] This application is a divisional application of a Chinese patent application with an application date of January 6, 2012, an application number of 201280004791.4, and an invention title of "polymer adsorbent for removing impurities from whole blood and blood products". [0002] related application [0003] This application claims priority to U.S. Patent Application Serial No. 13 / 344,166, filed January 5, 2012, and also claims the benefit of U.S. Provisional Application Serial No. 61 / 430,374, filed January 6, 2011, the entire disclosure of which is available through Incorporated herein by reference. technical field [0004] The present invention relates to methods for removing cytokines, bioactive lipids, free hemoglobin, membrane or cellular degradation products, inflammatory mediators, vasoactive substances, foreign antigens, drugs, antibodies, and Compositions and methods of reacting other substances. Background technique [0005] Transfusion of whole blood or der...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): B01D15/08B01J20/26B01J20/28B01J20/32A01N1/02
CPCA01N1/0263A01N1/0278A61P7/08B01J20/267B01J20/28004B01J20/28069B01J20/28078B01J20/3208B01J20/327B01J20/3272B01J20/328Y10T29/49826Y10T428/2982
Inventor 菲利普·P·哈恩文森特·J·卡波尼托马斯·D·戈洛比什胡迈拉·贝居姆·阿利
Owner CYTOSORBENTS CORP