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Method for preparing chitosan/bacterial cellulose sulfate composite blood compatible material

A technology of bacterial cellulose and blood compatibility, applied in the direction of cellulose/protein conjugated artificial filament, fiber chemical characteristics, conjugated synthetic polymer artificial filament, etc., can solve the limitation of electrospinning membrane and mechanical strength Poor problems, to achieve the effect of simple electrospinning technology

Active Publication Date: 2017-05-31
HAINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the fiber membrane obtained by electrospinning is a non-woven material with poor mechanical strength, the application of electrospun membranes should be greatly limited.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A preparation method of chitosan / bacterial cellulose sulfate electrospinning composite blood compatibility material, comprising the steps of:

[0027] (1) take by weighing 2.0g chitosan and be dissolved in 1% acetic acid, be mixed with the solution that concentration is 3%;

[0028] (2) take by weighing 5g polyvinyl alcohol and dissolve in distilled water, be mixed with the solution that concentration is 5%;

[0029] (3) take by weighing chitosan solution and polyvinyl alcohol solution that mass ratio is 6:1, mix and stir;

[0030] (4) laying the bacterial cellulose sulfate film with a surface sulfation degree of 0.04 on the electrospinning machine receiver;

[0031] (5) Electrospinning the obtained spinning solution under the conditions of a voltage of 10kv and a distance from the needle to the receiving plate of 10 cm can obtain uniform, bead-free fibers with a fiber diameter of 50-200 nm;

[0032] (6) Characterize the hemocompatibility of the composite film after g...

Embodiment 2

[0035] A preparation method of carboxymethyl chitosan / bacterial cellulose sulfate electrospinning composite blood compatibility material, comprising the steps of:

[0036] (1) take by weighing 2.4g chitosan and be dissolved in 1% acetic acid, be mixed with the solution that concentration is 6%;

[0037] (2) Take by weighing 4.8g ethyl cellulose and dissolve it in 80% ethanol to prepare a solution with a concentration of 16%;

[0038] (3) take by weighing chitosan solution and ethyl cellulose solution that mass ratio is 5:1.5, mix and stir;

[0039] (4) the bacterial cellulose sulfate film with a surface sulfation degree of 0.25 is placed on the electrospinning machine receiver;

[0040] (5) Electrospinning the resulting spinning solution at a voltage of 25kv and a distance of 20cm from the needle to the receiving plate to obtain uniform, bead-free fibers with a fiber diameter of 100-200nm;

[0041] (6) Characterize the hemocompatibility of the composite membrane after cross-...

Embodiment 3

[0044] A kind of preparation method of chitosan / bacterial cellulose sulfate electrostatic spinning composite film, comprises the steps:

[0045] (1) take by weighing 4.0g chitosan and be dissolved in 1% acetic acid, be mixed with the solution that concentration is 10%;

[0046] (2) Mix N,N-dimethylformamide and dichloromethane uniformly at a volume ratio of 7:3, add 6g of polylactic acid to it, and prepare a solution with a concentration of 12%;

[0047] (3) take by weighing chitosan solution and polylactic acid solution that mass ratio is 1.5:3, mix and stir;

[0048] (4) The bacterial cellulose sulfate film with a surface sulfation degree of 0.41 is placed on the electrospinning machine receiver;

[0049] (5) Electrospinning the obtained spinning solution under the conditions of a voltage of 40kv and a distance of 30cm from the needle head to the receiving plate can obtain uniform, bead-free fibers with a fiber diameter of 50-300nm;

[0050] (6) Characterize the hemocompat...

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PUM

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Abstract

The invention provides a method for preparing a chitosan / bacterial cellulose sulfate composite blood compatible material. The method comprises the following steps: (1) performing surface sulfating modification on bacterial cellulose; (2) weighing 1.2-3.2g of chitosan, dissolving in a dilute acetic acid solution, and preparing into a chitosan solution with the concentration of 3-10%; (3) preparing an easily spinning high polymer into a solution with the concentration of 5-16%; (4) mixing the chitosan solution and the easily spinning high polymer solution according to a mass ratio of 6:1 to 1:4 so as to obtain a spinning solution; and (5) spinning the spinning solution under an electrospinning device, and directly spinning onto a bacterial cellulose sulfate film, wherein the spinning voltage is 10-40kV, and the distance from a pin to a receiving plate is 10-30cm. Compared with the other heparinoid structure materials, the material provided by the invention has the advantages of simple preparation method, excellent mechanical properties and the like.

Description

technical field [0001] The invention relates to a preparation method of chitosan / bacterial cellulose sulfate compound blood compatibility material. Background technique [0002] With the development of modern medicine, biomaterials play an increasingly significant role in medical processes such as tissue replacement and repair. In addition to medical functionality, biocompatibility is an essential performance of biomaterials. Biocompatibility includes blood phase. compatibility and histocompatibility. Medical materials in contact with blood, such as hemodialysis materials, artificial blood vessels, artificial skin, etc., need to have good blood compatibility to inhibit the formation of blood clots in blood vessels (that is, anticoagulation) and maintain the normal composition and function of blood. [0003] Heparin is a natural blood anticoagulant. In the treatment of clinical hemodialysis and organ transplantation, it is usually necessary to take heparin orally or intraven...

Claims

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Application Information

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IPC IPC(8): D04H1/728D04H1/4382D01F8/18D01F8/10D01F8/14D01F8/16D01F8/02
CPCD01F8/02D01F8/10D01F8/14D01F8/16D01F8/18D04H1/4382D04H1/728
Inventor 尹学琼董文苑曾庆欢朱莉陈俊华
Owner HAINAN UNIVERSITY