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Application of albiglutide to medicines for treating and preventing diabetic mellitus complicated with cerebral infarction

A technology of albiglutide and cerebral infarction, which is applied in the application field of albiglutide in the treatment and prevention of diabetes combined with cerebral infarction, and can solve the problems of patients with backward treatment methods and failure to effectively control blood sugar

Inactive Publication Date: 2019-06-11
王敏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Complications caused by diabetes, such as visual impairment, low amputation, heart disease, etc., bring great pain to patients and their families, but most patients fail to effectively control blood sugar due to backward treatment methods and other reasons

Method used

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  • Application of albiglutide to medicines for treating and preventing diabetic mellitus complicated with cerebral infarction
  • Application of albiglutide to medicines for treating and preventing diabetic mellitus complicated with cerebral infarction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Example 1 The therapeutic effect of albiglutide on patients with diabetes mellitus complicated with cerebral infarction

[0012] Experimental objects and grouping: 360 cases of cerebral infarction patients within 48 hours of onset were randomly selected clinically, including 240 cases in the treatment group and 120 cases in the control group. In all cases, oral hypoglycemic drugs were used according to the condition, so that the fasting blood sugar was controlled at 6-8mmol / L, blood pressure was stabilized, and small doses of dehydrating agents, calcium antagonists (nimodipine), and platelet inhibitors (small doses of aspirin) were used. Anti-infection and other symptomatic treatment. Treatment group: subcutaneous injection of Albiglutide injection 30mg, once a day, 28 days as a course of treatment; control group: subcutaneous injection of the same amount of normal saline, once a day, 28 days as a course of treatment. Those with serious condition will take 2 courses of...

Embodiment 2

[0019] Example 2 Treatment of Albiglutide on Diabetes with Cerebral Infarction

[0020] 80 patients were randomly divided into two groups according to the random table generated by computer SPSS software. The treatment group consisted of 40 cases, 21 males and 19 females; aged 57.5-86.5 years old; neurological deficit score 15-39 points, with an average of (23.1±7.8) points. The control group consisted of 40 cases, 23 males and 17 females; aged 54.5-85.5 years; neurological deficit score l4-38 points, average (22.7 ± 6.6) points. There was no significant difference in gender, age, and neurological deficit scores between the two groups through statistical analysis (P>0.05), and they were comparable. Both groups were given routine treatment (OADs, dehydration drugs and supportive therapy, etc.). On this basis, the treatment group was given subcutaneous injection of albiglutide 30 mg, once a day, for 28 consecutive days; the control group was given the same amount of normal sal...

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PUM

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Abstract

The invention relates to a new medicinal use of albiglutide, namely an application of albiglutide to medicines for treating and preventing diabetic mellitus complicated with cerebral infarction, wherein the albiglutide is generally used in the manner of a medical composition. The composition contains an effective treatment amount of albiglutide as an active component and pharmaceutic adjuvants, medication is usually performed in the manner of subcutaneous injection, and the main preparation formulation is an injection. Clinical testing research proves that the treatment effect of the albiglutide on the diabetic mellitus complicated with cerebral infarction is better than patients suffering from nondiabetic mellitus complicated with cerebral infarction. The albiglutide not only can effectively relieve diabetic mellitus symptoms of patients, but also can improve the neurological function, so that restoration of entire illness state of the patients is facilitated.

Description

technical field [0001] The present invention relates to the field of medicinal chemistry, specifically, the present invention relates to the new medical application of albiglutide, that is, the application of albiglutide in the treatment and prevention of diabetes complicated with cerebral infarction. Background technique [0002] Albiglutide is a new type of GLP-1 drug whose main purpose is to restore β-cell dysfunction. Compared with exenatide and liraglutide, it has longer drug efficacy and in vivo half-life. [0003] Diabetes is a group of metabolic diseases characterized by hyperglycemia. Hyperglycemia is caused by defective insulin secretion or impaired biological action, or both. The long-term high blood sugar in diabetes leads to chronic damage and dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels, and nerves. It is a common chronic disease that seriously endangers human health. Currently, there are nearly 200 million diabetics in ...

Claims

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Application Information

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IPC IPC(8): A61K38/26A61K9/08A61P3/10A61P9/10
Inventor 王敏
Owner 王敏