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Compound rhubarb gel and preparation method and application thereof

A technology of yellow gel and compound recipe, applied in the field of traditional Chinese medicine, can solve the problems of lack of easy absorption, strong adhesion, non-greasy, etc.

Inactive Publication Date: 2019-06-14
苏州市吴江区中医医院(苏州市吴江区第二人民医院)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In view of the shortcomings of the prior art described above, the object of the present invention is to provide a compound rhubarb gel and its preparation method and application, which are used to solve the problems in the prior art that are easy to absorb, not greasy, and have strong adhesion on the skin surface. , Easy-to-clean external preparations of traditional Chinese medicine used to treat dermatological diseases

Method used

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  • Compound rhubarb gel and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0099] Take the components of the gel matrix according to the proportion: 12g of carbomer, 50g of glycerin, 5g of sodium hydroxide, 2g of Tween 80, 0.5g of ethylparaben, 10g of azone, 30g of ethanol, and 300g of matrix water. The matrix water is divided into the first part of matrix water 250g and the second part of matrix water 50g. Take a small amount of the first part of base water and mix glycerin to form the first mixed solution, then dissolve sodium hydroxide in the second part of base water to form an aqueous sodium hydroxide solution, then dissolve ethyl paraben and azone in ethanol to form the second mixed solution . Carbomer is Carbomer 940.

[0100] Slowly and evenly spread the carbomer into the first mixed solution for full infiltration, then add the remaining first part of matrix water to dilute, and stir at 60°C for 12 hours to fully swell the carbomer. Then slowly add aqueous sodium hydroxide solution and stir in one direction to obtain a gel intermediate, the...

Embodiment 2

[0104] The components of the gel matrix were taken according to the ratio: carbomer 11g, glycerin 45g, sodium hydroxide 4.5g, Tween 801.5g, ethylparaben 0.3g, azone 9g, ethanol 25g, matrix water 280g. The matrix water is divided into the first part of matrix water 240g and the second part of matrix water 40g. Take a small amount of the first part of base water and mix glycerin to form the first mixed solution, then dissolve sodium hydroxide in the second part of base water to form an aqueous sodium hydroxide solution, then dissolve ethyl paraben and azone in ethanol to form the second mixed solution . Carbomer is Carbomer 940.

[0105] Slowly and evenly spread the carbomer into the first mixed solution for full infiltration, then add the remaining first part of matrix water to dilute, and stir at 65°C for 10 hours to fully swell the carbomer. Then slowly add aqueous sodium hydroxide solution and stir in one direction to obtain a gel intermediate whose pH is 7.5.

[0106] Th...

Embodiment 3

[0109] The components of the gel matrix were taken according to the ratio: 13g of carbomer, 55g of glycerin, 5.5g of sodium hydroxide, 802.5g of Tween, 0.7g of ethylparaben, 11g of azone, 35g of ethanol, and 400g of matrix water. The matrix water is divided into the first part of matrix water 340g and the second part of matrix water 60g. Take a small amount of the first part of base water and mix glycerin to form the first mixed solution, then dissolve sodium hydroxide in the second part of base water to form an aqueous sodium hydroxide solution, then dissolve ethyl paraben and azone in ethanol to form the second mixed solution . Carbomer is Carbomer 940.

[0110] Slowly and evenly spread the carbomer into the first mixed solution for full infiltration, then add the remaining first part of matrix water to dilute, and stir at 55°C for 14 hours to fully swell the carbomer. Then slowly add sodium hydroxide aqueous solution and stir in one direction to obtain a gel intermediate,...

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Abstract

The invention provides a compound rhubarb gel comprising a gel matrix and a traditional Chinese medicine extract, wherein the gel matrix comprises the following raw materials and matrix water by weight: 10-14 parts of carbomer, 40-60 parts of glycerin; 1-3 parts of Tween 80; 4-6 parts of sodium hydroxide; 0.1-1 part of ethylparaben; 8-12 parts of azone; 20-40 parts of ethanol; an appropriate amount of matrix wawter. The traditional Chinese medicine extract comprises, by weight, 80-120 parts of rhubarb; 80-120 parts of forsythia; 80-120 parts of dandelion. The invention further provides a preparation method and use of the compound rhubarb gel. The compound rhubarb gel, the preparation method and the application have the effects of clearing away heat and detoxifying, reducing swelling and removing stasis, resolving carbuncle and expelling pus, and can be used for treating dermatological diseases such as acne, folliculitis and seborrheic dermatitis.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to a traditional Chinese medicine preparation for external use and a preparation method thereof, in particular to a compound rhubarb gel, a preparation method and application thereof. Background technique [0002] Gel refers to a thick liquid or semi-solid preparation in the form of uniform, suspension or emulsion made of raw material drug and excipients capable of forming gel. Because the gel has good biocompatibility, it has slow-release and controlled-release effects on drug release. The preparation process is simple and the appearance is beautiful. It is easy to apply and use. It is easy to absorb after local administration, does not pollute clothes, and has good stability. Therefore, it has been widely used in external preparations in dermatology, burns and ophthalmology. However, the bases of traditional Chinese medicine external preparations are mostly oil...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/32A61K36/708A61P17/00A61P17/10A61P17/08
Inventor 蹇强宋文琳潘永年张陶靓
Owner 苏州市吴江区中医医院(苏州市吴江区第二人民医院)
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