Application of hexarelin to preparing kidney ischemia reperfusion injury protecting drugs/drug combinations

A technology of ischemia-reperfusion and composition, which is applied in the field of biomedicine and can solve problems such as lack of strong evidence for drug effects
CN109908331AInactive Publication Date: 2019-06-21THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
THE AFFILIATED HOSPITAL OF QINGDAO UNIV
Publication Date
2019-06-21
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses application of hexarelin to preparing kidney ischemia reperfusion injury protecting drugs / drug combinations and belongs to the field of biological medicines. According to the application, the hexarelin is proved to possibly have protecting effects on rate ischemia reperfusion induced acute kidney injury; data prove that expression of SFN (stratifin) gene in a kidney ischemia reperfusion model is significantly increased, and with intervention of the hexarelin, is more significantly increased, while expression of apoptosis promoting genes of Bax, Bad and caspase3 are down-regulated, so that the hexarelin can protect kidney ischemia reperfusion injury by inhibiting apoptosis, and further by means of the molecular docking technology, possibility of interaction between hexarelin molecules and a 14-3-3 sigma protecting structure coded by the SFN gene can be testified, and a theoretical foundation for enlarging the possible application range of the hexarelin can be provided. The application of the hexarelin to preparing the kidney ischemia reperfusion injury protecting drugs / drug combinations can be applied to theoretical research and clinical application of kidneyischemia reperfusion injury and provide the theoretical foundation for enlarging the possible application range of the hexarelin.
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Description

technical field

[0001] The invention belongs to the field of biomedicine, and in particular relates to the application of hexarelin in the preparation of a drug / medicine composition for protecting the kidney from ischemia-reperfusion injury. Background technique

[0002] Acute Kidney Injury (AKI) refers to a series of clinical syndromes caused by a sudden (within 1-7d) and continuous (>24h) decline in glomerular filtration function due to various reasons, and it is common in renal artery embolism , kidney transplantation, severe renal vascular disease, shock, acute heart failure, etc. Studies have shown that renal proximal tubular epithelial cells are the most seriously affected part of renal ischemia-reperfusion injury, mainly manifested as renal tubular atrophy and disappearance, proximal tubular epithelial cells apoptosis, necrosis, shedding, and capillary around renal tubules reduce. Since there is still a lack of effective diagnostic and therapeutic means to block ...

Claims

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