Novel asymmetric wettable electrostatic spinning double-layer film and preparation method thereof

An electrospinning and asymmetric technology, applied in bandages, absorbent pads, medical science, etc., can solve the problems of not being suitable for large-scale production and complicated preparation process, and achieve the effect of promoting rapid healing, simple process and favorable absorption

Pending Publication Date: 2019-06-21
GUANGZHOU CHUANGSAI BIOLOGICAL MEDICAL MATERIALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the dressing is prepared by freeze-drying method, the preparation process is complicated, and specific surface of the material needs to be specially modified, which is not suitable for large-scale production
Unfortunately, so far, few clinically used wound dressings meet all the requirements of an ideal skin dressing

Method used

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  • Novel asymmetric wettable electrostatic spinning double-layer film and preparation method thereof
  • Novel asymmetric wettable electrostatic spinning double-layer film and preparation method thereof
  • Novel asymmetric wettable electrostatic spinning double-layer film and preparation method thereof

Examples

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Effect test

Embodiment 1

[0044] An embodiment of the novel asymmetric wettable electrospinning double-layer membrane of the present invention, the novel asymmetric wettable electrostatic spinning double-layer membrane described in this embodiment includes a hydrophobic layer and a hydrophilic layer, so The hydrophobic layer and the hydrophilic layer are bonded and connected; the hydrophobic layer is made of hydrophobic materials, and the hydrophilic layer is made of hydrophilic materials. The hydrophobic material is poly(lactic acid-glycolic acid); the hydrophilic material comprises PEG-COOH, silk fibroin and a cross-linking agent; the mass ratio of the PEG-COOH and silk fibroin is: PEG-COOH: Silk fibroin=10:3; the cross-linking agent is a mixture of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide.

[0045] The preparation method of the novel asymmetric wettable electrospinning double-layer membrane described in this example is as follows:

[0046] (1) Preparation...

Embodiment 2

[0049] An embodiment of the novel asymmetric wettable electrospinning double-layer membrane of the present invention, the novel asymmetric wettable electrostatic spinning double-layer membrane described in this embodiment includes a hydrophobic layer and a hydrophilic layer, so The hydrophobic layer and the hydrophilic layer are bonded and connected; the hydrophobic layer is made of hydrophobic materials, and the hydrophilic layer is made of hydrophilic materials. Described hydrophobic material is poly(lactic acid-glycolic acid) and polyacrylamide, and the mass ratio of described poly(lactic acid-glycolic acid) and polyacrylamide is: poly(lactic acid-glycolic acid):polyacrylamide=5: 1; the hydrophilic material comprises PEG-COOH, silk fibroin and a cross-linking agent; the mass ratio of the PEG-COOH to silk fibroin is: PEG-COOH: silk fibroin=10:3; the cross-linking agent The joint agent is a mixture of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysu...

Embodiment 3

[0054] An embodiment of the novel asymmetric wettable electrospun double-layer membrane of the present invention, the difference between the novel asymmetric wettable electrospun double-layer membrane described in this embodiment and Example 2 is only The difference lies in the hydrophilic material, the hydrophilic material comprises PEG-COOH, silk fibroin and cross-linking agent; the mass ratio of the PEG-COOH and silk fibroin is: PEG-COOH: silk fibroin=5: 1; The crosslinking agent is a mixture of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide.

[0055] The preparation method of the novel asymmetric wettable electrospinning double-layer membrane described in this example is as follows:

[0056] (1) Preparation of hydrophobic layer: with embodiment 2;

[0057] (2) Preparation of hydrophilic layer: Weigh 1.5g of carboxypolyethylene glycol (PEG-COOH) and 0.3g of silk fibroin dissolved in 10mL of hexafluoroisopropanol, stir for 12h with an e...

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Abstract

The invention discloses a novel asymmetric wettable electrostatic spinning double-layer film comprising a hydrophobic layer and a hydrophilic layer which are in fit connection. The hydrophobic layer is made of a hydrophobic material, the hydrophilic layer is made of a hydrophilic material, and the hydrophobic material and the hydrophilic layer are made by adopting an electrostatic spinning method.The hydrophobic layer is waterproof and resistant to adhesion and bacteria, so that adverse impact on skin wounds caused by intrusion of foreign substances is prevented; the hydrophilic layer enhances hydrophilicity and water retaining performance of the film, thereby being conductive to absorbing exudates of the wounds, maintaining humid environment of the wounds and promoting quick healing of the wounds. The film is prepared through electrostatic spinning technology, and the hydrophobic layer and the hydrophilic layer are high in controllability in design, so that the film can meet all requirements of ideal wound dressings. The invention further discloses a preparation method of the film.

Description

technical field [0001] The invention relates to a biomedical material, in particular to a novel asymmetric wettable electrostatic spinning double-layer membrane and a preparation method thereof. Background technique [0002] As the largest organ in the human body, the skin not only maintains our metabolism by preventing evaporation, but also plays an important role in protecting against UV rays, chemicals, foreign organisms and other harmful environmental agents. However, trauma and burns often lead to tissue necrosis, disrupting the skin's defenses. Wound infection is the most common complication of skin injuries and a major cause of delayed healing. Severe wound infection is associated with the development of bacteremia and sepsis, and may even lead to the development of systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS). Topical drugs are widely used in the treatment of burn wounds. However, when these drugs are used to treat ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/26A61L15/24A61L15/20A61L15/42A61L15/44A61L15/46
Inventor 蓝咏刘玉胡圣学朱麒宇冯龙宝
Owner GUANGZHOU CHUANGSAI BIOLOGICAL MEDICAL MATERIALS CO LTD
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