Pseudoephedrine slow release pellets and preparation method thereof
A technology of sustained-release pellets and pseudoephedrine, which is applied in the direction of pharmaceutical formulas, medical preparations containing no active ingredients, medical preparations containing active ingredients, etc., and can solve the problem of poor drug release uniformity and large individual differences in pharmacokinetics of sustained-release tablets and other issues to achieve the effect of improving drug stability and bioavailability
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Embodiment 1
[0042] The percentage in the prescription accounts for the ball core weight calculation with this component, and following each embodiment is identical.
[0043]
[0044]
[0045] Preparation Process:
[0046] Step 1: Mix pseudoephedrine and microcrystalline cellulose evenly, add the liquid pre-formulated by binder and wetting agent, and knead the powder to make a moist and uniform soft material with certain plasticity;
[0047] Step 2: Put the soft material in the extruder to extrude, put the extruded product in the spheronizer to round, discharge and dry to get the pellet core;
[0048] Step 3: Place the ball core in a fluidized bed coating machine that can heat / insulate the atomized compressed gas, coat it with the hot melt mixture of the preheated and insulated lipid material and the porogen, and air-dry it, that is Get pseudoephedrine slow-release pellets.
[0049] In step 2, the diameter of the sieve of the extruder is 0.5 mm to 1.5 mm, the rotation speed of the ...
Embodiment 2
[0058]
[0059]
[0060] Refer to Example 1 for the preparation process.
Embodiment 3
[0062]
[0063]Refer to Example 1 for the preparation process.
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