Unlock instant, AI-driven research and patent intelligence for your innovation.

Anastomosing nail material capable of degrading Mg-Zn-Ca-M in organism, and preparation method thereof

A mg-zn-ca-m, biological technology, applied in medical science, surgery, etc., can solve the problems of containing, etc., achieve the effect of relieving pain, promoting tissue repair, and improving prognosis

Active Publication Date: 2019-07-05
UNIV OF SCI & TECH BEIJING
View PDF13 Cites 17 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The invention can not only avoid the problems caused by the non-degradable in vivo clinical titanium staples, but also has good biocompatibility, good mechanical and degradation matching performance, and solves the problems in the existing biodegradable biomedical magnesium alloy technology. Problems with potentially toxic elements such as rare earth elements or aluminum

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Example 1: Mg-1Zn-0.2Ca-4Ag

[0062] Weigh the required high-purity alloy raw materials in proportion, among which the purity of magnesium ingots is greater than or equal to 99.99%, the purity of zinc particles is greater than or equal to 99.99%, the purity of magnesium-calcium master alloys is greater than or equal to 99.99%, and the purity of silver particles is greater than or equal to Equal to 99.99%. After the surface of the raw material is polished, the magnesium ingot is heated and melted in a high-purity graphite crucible. 6 and CO 2 Under the protection of high-purity gas, add the rest of the raw materials one by one, raise the temperature to 750°C and keep it warm for 20 minutes, then cool down to 710°C for casting. The casting mold is a water-cooled steel mold.

[0063] Subsequently, the ingot was subjected to homogenization treatment, the holding temperature was 430° C., the holding time was 16 hours, and water quenched after holding. The homogenized ingo...

Embodiment 2

[0066] Embodiment 2: Mg-1Zn-0.2Ca-0.2Mn

[0067] Weigh the required high-purity alloy raw materials in proportion, among which the purity of magnesium ingots is greater than or equal to 99.99%, the purity of zinc particles is greater than or equal to 99.99%, the purity of magnesium-calcium master alloys is greater than or equal to 99.99%, and the purity of magnesium-manganese master alloys The degree is greater than or equal to 99.99%. After the surface of the raw material is polished, the magnesium ingot is heated and melted in a high-purity graphite crucible. 6 and CO 2 Under the protection of high-purity gas, add the rest of the raw materials one by one, raise the temperature to 750°C and keep it warm for 20 minutes, then cool down to 710°C for casting. The casting mold is a water-cooled steel mold.

[0068] Subsequently, the ingot is subjected to homogenization treatment, the holding temperature is 450° C., the holding time is 24 hours, and water quenching after holding....

Embodiment 3

[0071] Embodiment 3: Mg-1Zn-0.2Ca-4Sn

[0072] Weigh the required high-purity alloy raw materials in proportion, among which the purity of magnesium ingots is greater than or equal to 99.99%, the purity of zinc particles is greater than or equal to 99.99%, the purity of magnesium-calcium master alloys is greater than or equal to 99.99%, and the purity of tin particles is greater than or equal to Equal to 99.99%. After the surface of the raw material is polished, the magnesium ingot is heated and melted in a high-purity graphite crucible. 6 and CO 2 Under the protection of high-purity gas, add the rest of the raw materials one by one, raise the temperature to 750°C and keep it warm for 20 minutes, then cool down to 710°C for casting. The casting mold is a water-cooled steel mold.

[0073] Subsequently, the ingot is subjected to homogenization treatment, the holding temperature is 450° C., the holding time is 24 hours, and water quenching after holding. The homogenized ingot ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Tensile strengthaaaaaaaaaa
Average corrosion rateaaaaaaaaaa
Tensile strengthaaaaaaaaaa
Login to View More

Abstract

The invention discloses an anastomosing nail material capable of degrading a magnesium alloy in an organism, and a preparation method thereof. The magnesium alloy consists of Mg-Zn-Ca-M, wherein M isarbitrary combination of one or more elements of Ag, Mn, Sn, Sr, Zr and Ge. The targeted alloy is obtained through smelting casting, homogenizing treatment and hot extrusion, or through room temperature drawing and annealing treatment. Compared with the prior art, a magnesium alloy material prepared with the adoption of the component and the preparation method has the relatively high intensity andplasticity, and the controllable degrading rate, and can be naturally degraded in the organism, degrading products have no toxic or side effects, necessary nutritional supplement is provided further,and the magnesium alloy material has the relatively high biological safety. With the adoption of the anastomosing nail material for an anastomat suitable for a suturing surgery or an anastomosing surgery of organs such as the oral cavity and the stomach and intestine, a second surgery is avoided, and the pain of a patient is relieved. The slight amount of silver element released further inhibitsa bacterial inflammation around an implantation material.

Description

technical field [0001] The invention relates to a degradable medical metal material, in particular to a high-strength degradable medical magnesium alloy which can be used for oral or gastrointestinal staplers and a preparation method thereof. Background technique [0002] Staples are an important part of the stapler used in mechanical anastomosis in oral and gastrointestinal anastomosis. According to different models and parameters of the stapler, the parameters such as the height and diameter of the staple also change accordingly. During the anastomosis process, the staple mainly passes through the two layers of tissue by activating the handle, and the staple is blocked when it reaches the anvil of the stapler, and is bent inward to form a "B" shape. Staples used in traditional staplers are generally made of titanium alloy and tantalum metal, which are used to separate and anastomose tissues. Their chemical properties are stable and can be retained in the human body for a l...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C22C23/00C22C23/04C22F1/06A61L31/02A61L31/14C22C1/03
CPCA61L31/022A61L31/14A61L31/148C22C1/03C22C23/00C22C23/04C22F1/06
Inventor 李宏祥张济山马英中王德鑫
Owner UNIV OF SCI & TECH BEIJING