Absorbable polymer blend compositions having enhanced nucleation rates
A polymer, absorbent technology, applied in the field of new absorbent polymer blend compositions, can solve problems such as no research
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Embodiment 1
[0052] Synthesis of Poly(p-dioxanone): Standard Molecular Weight Polymer (PDS)
[0053] Into a suitable conventional 65 gallon stainless steel oil-jacketed reactor equipped with an agitator was charged 164.211 kg of p-dioxanone monomer (PDO), along with 509 grams of dodecanol, 164 grams of D&C Violet No. 2 dye, and 100 grams of 0.33M stannous octoate in toluene. The reactor was closed and the purge cycle was started while stirring at a rotational speed of 12 RPM in an upward direction. The reactor was evacuated to a pressure of less than 500 mTorr, and then nitrogen gas was introduced. Repeat this cycle several times to ensure a dry atmosphere.
[0054] At the end of the last nitrogen introduction, the pressure was adjusted to slightly above one atmosphere. Heat the vessel at a rate of 180°C / hour until the oil temperature reaches about 100°C. The vessel was maintained at 100°C until the batch temperature reached 50°C, at which point the agitator rotation was switched to ...
Embodiment 2
[0059] Synthesis of Poly(p-dioxanone): Ultra High Molecular Weight Polymers (UHMWPDS)
[0060] The synthesis procedure for ultra-high molecular weight poly(p-dioxanone) UHMWPDS was the same as described in Example 1, except that a lower initiator content was used (monomer to initiator ratio of 5,500:1) and Longer-lasting solid phase.
[0061] Solid state curing was carried out at 80°C for 14 days, followed by grinding, sieving and drying steps. The resulting dry polymer UHMWPDS had a glass transition temperature of -7.6°C, a melting point of 117°C and an enthalpy of fusion of 93.2 J / g as measured by DSC using a heating rate of 10°C / min. The resin had a weight average molecular weight of 330,000 Daltons, as determined by the GPC method, and exhibited an intrinsic viscosity of 5.25 dL / g, as determined in hexafluoroisopropanol at a concentration of 0.10 g / dL at 25°C. measured. NMR analysis confirmed that the resin was poly(p-dioxanone), with a residual monomer content of less ...
Embodiment 3
[0063] Dry Blending of Unimodal PDS Homopolymers
[0064] Appropriate amounts of dry poly(p-dioxanone) of standard weight average molecular weight (Example 1) and ultrahigh molecular weight component (Example 2) were mixed in a dry blend in separate form (milled) . These dry blends are prepared on a weight basis, depending on the particular application and surgical needs. In this example, standard poly(p-dioxanone) resin and UHMWPDS were dry mixed as described directly below.
[0065] A clean 3 cubic foot Patterson-Kelley dryer was charged with the specified amounts of the dried resins of Example 1 and Example 2. The dryer was turned off, and the vessel pressure was reduced to less than 200 mTorr. The rotation was started at 7.5 RPM for a minimum period of one hour. The dry blend was then discharged into conventional portable vacuum storage containers and these containers were placed under vacuum until ready for the melt blending step.
[0066] For the purposes of this ...
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