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Use of beta-nicotinamide mononucleotide or precursor thereof in preparation of medicines or health products for treating or alleviating respiratory disorders or diseases
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A single nucleotide, breathing disorder technology, applied in the field of medicine
Active Publication Date: 2019-07-12
SICHUAN UNIV
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[0014] Currently, there is no β-nicotinamide mononucleotide (NMN) and β-nicotinamide riboside (Nicotinamide Riboside, NR) to treat or alleviate chronic obstructive pulmonary disease and treat or alleviate the symptoms caused by inhalable particles. Reports on lung diseases, especially the aging of lung macrophages
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[0076] (1) Establishment of mouse model of chronic obstructive pulmonary disease
[0077] Animals: 6-8 weeks, C57 mice;
[0078] Reagent: porcine pancreatic elastase solution PPE (USA, Sigma), diluted in sterile PBS;
[0079] method:
[0080] 1) Anesthetize the mouse (adding isoflurane at a rate between 1.5-2 L / min), remove it from the box and place it in a supine position on a ramp, carefully open its mouth and attach the rubber band to the upper incisors , to lift the rubber band from the nail.
[0081] 2) Using a small pair of tweezers, gently grasp the mouse's tongue, pull it out from the mouth by 0.5-1 cm, and drop the elastase solution (50 μL) on the distal end of the oropharynx, that is, behind the tongue.
[0082] 3) Hold the tongue with one hand and block the two nostrils with the other hand for 5-6 seconds. With the extension of the tongue and the blockage of...
Embodiment 2
[0135] Example 2 β-nicotinamide mononucleotide NMN and β-nicotinamide ribose NR reduce the aging of lung macrophages caused by carbon particles, etc.
[0136] (1) Extraction of C57BL / 6 macrophages
[0137] To extract C57BL / 6 alveolar macrophages, cut the ribs of the mouse thorax so that the lungs can fully expand, then separate the trachea, cut a small opening along the cricoid cartilage, insert a flattened 20ml empty needle into the trachea, and suck 1ml of physiological Inject saline into the trachea, fix the needle with a needle holder, withdraw, repeat twice, centrifuge at 1000 rpm, process for 5 minutes, wash once with DMEM, transfer to a culture dish, add DMEM (containing calf serum), and wait for 2 hours to adhere to the wall , the original medium was discarded, and the resulting adherent cells were alveolar macrophages. For the extraction of C57BL / 6 peritoneal macrophages, inject 10ml of normal saline into the peritoneal cavity of the mouse, massage the two sides of t...
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Abstract
The invention belongs to the technical field of medicine, and in particular, relates to a use of beta-nicotinamide mononucleotide or a precursor thereof in preparation of medicines or health productsfor treating or alleviating respiratory disorders or diseases. The technical problem to be solved by the invention comprises that a new alternative scheme is provided for preparation of the medicinesor health products for treating or alleviating the respiratory disorders or diseases, and the technical scheme for solving the technical problem comprises that provided is the use of the beta-nicotinamide mononucleotide or the precursor thereof in preparation of the medicines or health products for treating or alleviating the respiratory disorders or diseases. The beta-nicotinamide mononucleotideor beta-nicotinamide riboside can effectively treat pulmonary diseases such as chronic obstructive pulmonary disease, can significantly alleviate the aging of pulmonary macrophages caused by inhalablegranules, and has a good application prospect.
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