Preparation method of gold nanorod-based engineering nano gel

A technology of gold nanorods and nanogels, which is applied in the field of polymer biomedical materials, can solve the problem of not further combining the photothermal properties of gold nanorods, and achieve a simple and efficient gelation method, a wide range of applications, and is conducive to cell internalization Effect

Pending Publication Date: 2019-07-12
TONGJI UNIV
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Problems solved by technology

This patent uses the self-assembly property of amino groups in polypeptide molecules to synthesize nanogels when the pH changes, and does not further improve the photothermal properties of gold nanorods themselves, so as to realize nanogels in therapeutic Aspects of application

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  • Preparation method of gold nanorod-based engineering nano gel
  • Preparation method of gold nanorod-based engineering nano gel
  • Preparation method of gold nanorod-based engineering nano gel

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Embodiment Construction

[0043] The present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0044] The reagents used in the examples are all commercially available products purchased, and the specific merchant models are shown in Table 1.

[0045] Table 1 List of Reagents

[0046]

[0047] A preparation method of gold nanorod-based engineering nanogel, the method is: using mercapto hyaluronic acid to carboxyl-modify and activate the surface of gold nanorods, then grafting acid phosphatase, adding small molecule gel factor for enzymatic The small molecular gel molecules are self-assembled and deposited on the surface of gold nanorods to form nanogels, and then chloroperoxidase is loaded on the nanogels to obtain gold nanorod-based engineering nanogels. Among them, the small molecule gelling factor is Fmoc-Tyr (H 2 PO 3 )-OH. Specific as figure 1 As shown, the method specifically includes the following steps:

[0048] (1) Dis...

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Abstract

The invention relates to a preparation method of a gold nanorod-based engineering nano gel, wherein the method comprises the steps: with a gold nanorod as an inorganic core, modifying the surface of the gold nanorod with carboxyl groups by mercaptohyaluronic acid and activating; then grafting with acid phosphatase, adding a small molecular gel factor, making the property of the small molecular gelfactor changed from hydrophilcity to hydrophobicity by the enzyme digestion effect of the acid phosphatase, and self-assembling on the surface of the gold nanorod to form nano gel; and finally, loading the nano gel with chloroperoxidase, and thus obtaining the gold nanorod-based engineering nano gel. Compared with the prior art, the gelling method is simple and high in efficiency, both the gelling thickness and speed are adjustable, and the method applied in photothermal-enzyme combined therapy has mild and high-efficiency characteristics.

Description

technical field [0001] The invention belongs to the technical field of polymer biomedical materials, and in particular relates to a preparation method of gold nanorod-based engineering nanogel. Background technique [0002] Nanogel is a nanometer-sized three-dimensional cross-linked nanoparticle, which has both the characteristics of nanomaterials and the characteristics of hydrogels. Its nanometer size can increase the time of circulation in the body, has excellent biocompatibility, is easy to surface modification, and can provide targeting. Hydrogels are self-assembled by gelling factors in water through non-covalent bonds. The network structure of microgels enables them to load guest molecules such as drugs, so they have great application potential in the field of biology. [0003] In recent years, with the rapid development of nanotechnology, organic-inorganic hybrid nanogels have attracted much attention. This hybrid nanogel combines the functionality of inorganic mat...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/06A61K47/54A61P35/00
CPCA61K41/0052A61K41/0057A61K9/06A61K47/542A61P35/00A61K2300/00
Inventor 汪晓珊王霞王启刚
Owner TONGJI UNIV
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