Preparation method of gold nanorod-based engineering nano gel

Abstract

The invention relates to a preparation method of a gold nanorod-based engineering nano gel, wherein the method comprises the steps: with a gold nanorod as an inorganic core, modifying the surface of the gold nanorod with carboxyl groups by mercaptohyaluronic acid and activating; then grafting with acid phosphatase, adding a small molecular gel factor, making the property of the small molecular gelfactor changed from hydrophilcity to hydrophobicity by the enzyme digestion effect of the acid phosphatase, and self-assembling on the surface of the gold nanorod to form nano gel; and finally, loading the nano gel with chloroperoxidase, and thus obtaining the gold nanorod-based engineering nano gel. Compared with the prior art, the gelling method is simple and high in efficiency, both the gelling thickness and speed are adjustable, and the method applied in photothermal-enzyme combined therapy has mild and high-efficiency characteristics.

Description

technical field

[0001] The invention belongs to the technical field of polymer biomedical materials, and in particular relates to a preparation method of gold nanorod-based engineering nanogel. Background technique

[0002] Nanogel is a nanometer-sized three-dimensional cross-linked nanoparticle, which has both the characteristics of nanomaterials and the characteristics of hydrogels. Its nanometer size can increase the time of circulation in the body, has excellent biocompatibility, is easy to surface modification, and can provide targeting. Hydrogels are self-assembled by gelling factors in water through non-covalent bonds. The network structure of microgels enables them to load guest molecules such as drugs, so they have great application potential in the field of biology.

[0003] In recent years, with the rapid development of nanotechnology, organic-inorganic hybrid nanogels have attracted much attention. This hybrid nanogel combines the functionality of inorganic mat...

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