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Au@Se@Pt-Ce6 nano composite probe and preparation method thereof

A nano-composite and probe technology, applied in drug combinations, pharmaceutical formulations, photodynamic therapy, etc., can solve the problems of discounted treatment effect, inability to achieve oxygen production, poor stability, etc., and achieve high photothermal conversion efficiency, good photothermal Stability, good photoacoustic imaging effect

Active Publication Date: 2019-07-23
NANJING UNIV OF POSTS & TELECOMM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Au@Se is mainly used as a photothermal reagent, which cannot produce oxygen in situ at the tumor site, lacks photosensitizers, and has poor stability during heating, which greatly reduces the therapeutic effect.

Method used

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  • Au@Se@Pt-Ce6 nano composite probe and preparation method thereof
  • Au@Se@Pt-Ce6 nano composite probe and preparation method thereof
  • Au@Se@Pt-Ce6 nano composite probe and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) Mix 0.5mL chloroauric acid (concentration: 24.28mM) with 50mL deionized water, boil the mixture, add 1mL sodium citrate solution (concentration: 34mM), keep it for 15min, then cool to room temperature. Gold nanoparticles were purified by centrifugation at 10,000 rpm for 10 minutes and dispersed into 5.5 mL of deionized water. At 30 °C, mix the gold nanoparticles with 1.6 mL of surfactant PAA solution (10 mg / mL concentration).

[0037] (2) Add 0.1mL selenium dioxide (concentration: 100mM) and 0.15mL ascorbic acid (concentration: 200mM) to step (1) in sequence, keep the temperature at 30°C, and react for 10 minutes to obtain Au@Se nanoparticle solution.

[0038] (3) After the Au@Se nanoparticle solution prepared in step (2) was rapidly heated to 60 °C, 0.3 mL of chloroplatinic acid solution (concentration: 19.3 mM) was slowly added dropwise, and Au@Se / Pt nanoparticles solution.

[0039] (4) After the Au@Se / Pt nanoparticle solution prepared in step (3) was purified ...

Embodiment 2

[0042] Others are the same as in Example 1, except that the surfactant in step 1 is PSS.

Embodiment 3

[0044] Others are the same as in Example 1, except that the surfactant in step 1 is PVP.

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Abstract

The invention provides a preparation method of an Au@Se@Pt-Ce6 nano composite probe. The method comprises the following steps: (1) preparing Au nanoparticles, uniformly mixing an Au nanoparticle solution with a surfactant solution at 20-40 DEG C, adding a selenium source and ascorbic acid for reaction so as to obtain an Au@Se nanoparticle solution; (2) adding a Pt ion solution for reaction to obtain an Au@Se@Pt nanoparticle solution; and (3) modifying Ce6 in the Au@Se@Pt nanoparticle solution to obtain the Au@Se@Pt-Ce6 probe. The Au@Se@Pt-PAH-Ce6 nano composite probe synthesized by the methodhas good photothermal conversion performance, photodynamic treatment effect, photoacoustic imaging and thermal imaging capability, can be applied to photothermal treatment, photodynamic treatment andimaging for tumor cells, and has good application prospect in the aspect of multimodal imaging diagnosis and treatment of tumors.

Description

technical field [0001] The invention relates to a nanocomposite probe, specifically an Au@Se@Pt-Ce6 nanocomposite probe, which belongs to the technical field of functional materials. Background technique [0002] Compared with conventional surgery, chemotherapy, and radiotherapy, phototherapy, especially near-infrared light, has become a new therapeutic modality in cancer treatment due to its unique characteristics, including superior tissue penetration ability. Photodynamic therapy (PDT) and photothermal therapy (PTT) are two main forms of phototherapy, which require photosensitizers / radiosensitizers to convert light energy into singlet oxygen and heat energy, destroying tumor tissue and killing cancer cells . However, the hypoxic nature of the microenvironment around the tumor is not conducive to the action of photosensitizers, because photosensitizers require oxygen molecules to exert cytotoxic effects and kill tumor cells. In addition, photothermal therapy cannot compl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K49/00A61K49/22A61P35/00A61K33/243
CPCA61K41/0052A61K41/0057A61K49/0002A61K49/225A61P35/00A61K33/243A61K2300/00
Inventor 沈清明苏金中戴叶能赵红海范曲立
Owner NANJING UNIV OF POSTS & TELECOMM
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