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Vildagliptin blood sugar-reducing chewable tablet and preparation method thereof

A technology of vildagliptin and chewable tablets, applied in the field of vildagliptin hypoglycemic chewable tablets and its preparation, can solve the problems of no obvious curative effect on reducing diabetic complications, too fast and too much blood sugar rise after meals, etc. Achieve the effects of promoting the proliferation and differentiation of islet β cells, enhancing satiety, and preventing hyperglycemia

Inactive Publication Date: 2019-07-26
南京瑄宇医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The current drugs for the treatment of diabetes all focus on how to prevent the postprandial blood sugar from rising too fast and too much. The existing vildagliptin hypoglycemic drugs have no obvious effect on reducing the occurrence of diabetic complications

Method used

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  • Vildagliptin blood sugar-reducing chewable tablet and preparation method thereof
  • Vildagliptin blood sugar-reducing chewable tablet and preparation method thereof
  • Vildagliptin blood sugar-reducing chewable tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] A vildagliptin hypoglycemic chewable tablet, comprising the following components in parts by mass:

[0061] Vildagliptin 10 parts;

[0062] 8 parts of seaweed polysaccharide;

[0063] Sodium alginate 4 parts;

[0064] Vitamin C 4 parts;

[0065] 15 parts protein sugar;

[0066] Forming agent 50 parts;

[0067] Lubricant 2 parts.

[0068] Specifically, the forming agent is methyl cellulose; the lubricant is magnesium stearate.

[0069] The preparation method of the above-mentioned vildagliptin hypoglycemic chewable tablet comprises the following steps:

[0070] (1) After crushing vildagliptin, laver polysaccharide, sodium alginate and vitamin C respectively and passing through a 100-mesh sieve, they are respectively prepared for use, and then vildagliptin, laver polysaccharide and vitamin C are mixed according to the mass parts Uniformly, to obtain drug mixture;

[0071] (2) Mix the drug mixture and forming agent obtained in step (1) evenly to obtain the base mat...

Embodiment 2

[0074] A vildagliptin hypoglycemic chewable tablet, comprising the following components in parts by mass:

[0075] Vildagliptin 13 parts;

[0076] 6 parts of laver polysaccharide;

[0077] Sodium alginate 6 parts;

[0078] Vitamin C 6 parts;

[0079] 20 parts protein sugar;

[0080] Forming agent 40 parts;

[0081] Lubricant 3 parts.

[0082] Specifically, the forming agent is a composition of starch slurry, gelatin and methylcellulose, and their mass ratio is 2:1:2; the lubricant is talcum powder.

[0083] The preparation method of the above-mentioned vildagliptin hypoglycemic chewable tablet comprises the following steps:

[0084] (1) After crushing vildagliptin, laver polysaccharide, sodium alginate and vitamin C respectively and passing through a 100-mesh sieve, they are respectively prepared for use, and then vildagliptin, laver polysaccharide and vitamin C are mixed according to the mass parts Uniformly, to obtain drug mixture;

[0085] (2) Mix the drug mixture and...

Embodiment 3

[0088] A vildagliptin hypoglycemic chewable tablet, comprising the following components in parts by mass:

[0089] Vildagliptin 15 parts;

[0090] 4 parts laver polysaccharide;

[0091] Sodium alginate 8 parts;

[0092] Vitamin C 8 parts;

[0093] 25 parts protein sugar;

[0094] 30 parts of forming agent;

[0095] Lubricant 4 parts.

[0096] Specifically, the forming agent is a composition of starch slurry and gelatin, and their mass ratio is 3:2;

[0097] Described lubricant is magnesium stearate.

[0098] The preparation method of the above-mentioned vildagliptin hypoglycemic chewable tablet comprises the following steps:

[0099] (1) After crushing vildagliptin, laver polysaccharide, sodium alginate and vitamin C respectively and passing through a 100-mesh sieve, they are respectively prepared for use, and then vildagliptin, laver polysaccharide and vitamin C are mixed according to the mass parts Uniformly, to obtain drug mixture;

[0100] (2) Mix the drug mixture...

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Abstract

The invention discloses a vildagliptin blood sugar-reducing chewable tablet and a preparation method thereof and belongs to the field of hypoglycemic drugs. The vildagliptin blood sugar-reducing chewable tablet comprises, by mass, 10-15 parts of vildagliptin, 4-8 parts of laver polysaccharide, 4-8 parts of sodium alginate, 4-8 parts of vitamin C, 15-25 parts of protein sugar, 30-50 parts of a molding agent and 2-4 parts of a lubricant. The preparation method comprises the following steps: firstly mixing vildagliptin, laver polysaccharide and vitamin C according to the parts by mass to obtain adrug mixture, mixing the drug mixture with a forming agent, dissolving the drug mixture in purified water of 70 DEG C, adding protein sugar and sodium alginate to prepare a soft material, extruding,granulating, drying, granulating, mixing with a lubricant, and executing tabletting to obtain the vildagliptin blood sugar-reducing chewable tablet. The hypoglycemic effect of the hypoglycemic drug isimproved, and diabetic complications can also be reduced; the medicine prepared by the preparation method is good in specification uniformity and high in preparation efficiency.

Description

technical field [0001] The invention relates to the field of hypoglycemic drugs, in particular to a vildagliptin hypoglycemic chewable tablet and a preparation method thereof. Background technique [0002] Diabetes is a group of metabolic diseases characterized by hyperglycemia. Hyperglycemia is caused by defective insulin secretion or impaired biological action, or both. The long-term high blood sugar in diabetes leads to chronic damage and dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels, and nerves. After the human body eats, the body supplements more glycogen, which will lead to a sudden increase in blood sugar after decomposition. For diabetics, postprandial blood sugar is the main control object. [0003] Vildagliptin is a dipeptidyl peptidase IV (DPP-IV) inhibitor, also known as an incretin enhancer, which reduces the activity of glucagon-like peptide 1 (GLP-1) by inhibiting the activity of DPP-IV. ) degradation rate, and then stim...

Claims

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Application Information

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IPC IPC(8): A61K31/734A61K31/715A61K31/40A61K31/375A61K9/20A61K47/26A61K47/42A61P3/10A61J3/10
CPCA61K31/734A61K31/715A61K31/40A61K31/375A61K9/2018A61K9/2063A61K9/0056A61P3/10A61J3/10A61K2300/00
Inventor 吴娟王燕红
Owner 南京瑄宇医药科技有限公司
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