Preparing method and application of near-infrared response carbon dots

A near-infrared and carbon dot technology, applied in chemical instruments and methods, medical preparations containing active ingredients, nano-carbon, etc., can solve problems such as high cost, limited application of carbon quantum dots, and long preparation cycle

Active Publication Date: 2019-07-30
SHANGHAI SIXTH PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, using traditional methods to prepare carbon quantum dots, the disadvantages of long preparation p...

Method used

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  • Preparing method and application of near-infrared response carbon dots
  • Preparing method and application of near-infrared response carbon dots
  • Preparing method and application of near-infrared response carbon dots

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Embodiment 1

[0052] This embodiment is a method for preparing carbon dots responding to the second near-infrared region, which includes the following steps:

[0053] 1) Add 2g of pyrene to 160mL of concentrated nitric acid, condense and reflux at 80°C for 24 hours, dilute the resulting mixture with deionized water to wash the acid in the solution, and finally use a 220nm filter to remove large particles, and then dry to obtain trinitrate Base pyrene powder.

[0054] 2) Take 0.1 g of trinitropyrene obtained in the first step, dissolve 0.1 g of polyethyleneimine in 10 mL of deionized water and stir and mix with trinitropyrene, put it into a microwave reactor, and react at 150 ° C for 120 min.

[0055] 3) the black liquid obtained in step 2 is passed through a 220nm filter membrane, the filtrate is forwarded to the dichloromethane phase, and the neutral alumina chromatography column is used to filter and remove the small molecular organic matter for reaction, and then dry to obtain a black po...

Embodiment 2

[0057] This embodiment is a method for preparing carbon dots responding to the second near-infrared region, which includes the following steps:

[0058] 1) Add 3g of pyrene to 240mL of concentrated nitric acid, condense and reflux at 80°C for 30h, dilute the resulting mixture with deionized water to wash the acid in the solution, and finally use a 220nm filter to remove large particles, and then dry to obtain trinitrate Base pyrene powder.

[0059] 2) Take 0.1 g of trinitropyrene obtained in the first step, dissolve 2.5 g of polyethyleneimine in 10 mL of deionized water and stir and mix with trinitropyrene, put it into a microwave reactor, and react at 170 ° C for 80 min.

[0060] 3) the black liquid obtained in step 2 is passed through a 220nm filter membrane, the filtrate is forwarded to the dichloromethane phase, and the neutral alumina chromatography column is used to filter and remove the small molecular organic matter for reaction, and then dry to obtain a black powder. ...

Embodiment 3

[0062] This embodiment is a method for preparing carbon dots responding to the second near-infrared region, which includes the following steps:

[0063] 1) Add 4g of pyrene to 320mL of concentrated nitric acid, condense and reflux at 80°C for 48h, dilute the resulting mixture with deionized water to wash the acid in the solution, and finally use a 220nm filter to remove large particles, and then dry to obtain trinitrate Base pyrene powder.

[0064] 2) Take 0.1 g of trinitropyrene obtained in the first step, dissolve 0.8 g of polyethyleneimine in 10 mL of deionized water and stir and mix with trinitropyrene, put it into a microwave reactor, and react at 180 ° C for 2 minutes.

[0065] 3) Pass the black liquid obtained in step 2 through a 220nm filter membrane, transfer the filtrate to the dichloromethane phase, filter with a neutral alumina chromatography column to remove the small molecule organic matter for the reaction, and then dry to obtain a black powder, namely NIR -II-...

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Abstract

The invention provides a preparing method of near-infrared response carbon dots. The preparing method includes the following steps that trinitro-pyrene and a polyethyleneimine water solution are mixedevenly, and react for 1 min to 120 min in a microwave reactor at the temperature of 150 DEG C to 230 DEG C, and the reaction product is filtered, subjected to chromatography and dried, and the carbondots are obtained. The invention also relates to application of the near-infrared response carbon dots. The carbon dots for near-infrared-region photo-thermal treatment are prepared with the rapid and efficient microwave method, the carbon dots have the excellent photo-thermal conversion efficiency, and an in-vivo and in-vitro imaging aim is achieved by effectively combining the carbon dots and fluorescence-imaging small molecules; the carbon dots are combined with small molecule drug doxorubicin, the whole system has two treatment modes of photo-thermal treatment and chemotherapy, and through combination treatment, the treatment power is lower and has better safety and higher efficiency.

Description

technical field [0001] The invention belongs to the technical field of carbon quantum dot preparation, in particular to a preparation method and application of near-infrared responsive carbon dots. Background technique [0002] Tumor refers to a new organism formed by the proliferation of local tissue cells under the action of various tumorigenic factors. Malignant tumors have biological characteristics such as abnormal cell differentiation and proliferation, uncontrolled growth, invasion, and metastasis. Its occurrence is a multi-factor and multi-step complex process, which is closely related to environment, personal life and eating habits, smoking, alcohol intake, infection and genetic factors. The treatment of malignant tumors is the frontier and hot spot of current scientific research. Although surgical treatment is the preferred method for many tumors, there are problems such as tumor spread and trauma to patients. Malignant tumors are a serious threat to human health...

Claims

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Application Information

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IPC IPC(8): C09K11/65B82Y20/00B82Y40/00C01B32/15A61K41/00A61K31/704A61P35/00
CPCC09K11/65B82Y20/00B82Y40/00C01B32/15A61K41/0052A61K31/704A61P35/00A61K2300/00
Inventor 沈龙祥潘登余耿弼江
Owner SHANGHAI SIXTH PEOPLES HOSPITAL
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