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Preparation method of betamethasone tablets

A technology of betamethasone and corn starch, applied in the field of medicine, can solve the problems of high cost, one-sided roughness and low hardness, and achieve the effects of changing properties, good gloss and increasing adhesion

Inactive Publication Date: 2019-08-09
安徽金太阳生化药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing betamethasone tablets have problems such as high cost, loose tablets, rough surface, and low hardness

Method used

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Embodiment Construction

[0017] A preparation method for betamethasone tablet, comprising the following steps:

[0018] A kind of betamethasone tablet, in order to prepare 100,000 tablets of betamethasone tablet, the raw material components of this betamethasone tablet are betamethasone 0.05kg, cornstarch 7.1kg, sucrose 3.15kg, carboxymethyl starch sodium 0.85kg, Sodium lauryl sulfate 0.2kg, magnesium stearate 0.1kg, povidone K30 0.05kg.

[0019] (1) Grinding and pre-mixing: According to the prescription ratio, add 0.05kg of betamethasone and 0.85kg of sodium starch glycolate into a two-dimensional mixer and mix for 10-20min, then add 7.1kg of corn starch and 3.15kg of sucrose and mix for 15-30min, and finally Pulverized into 100 mesh powder;

[0020] (2) pulping: 0.05kg povidone K30 is added into 1.65kg purified water, stirred to make a slurry with a concentration of 3%;

[0021] (3) Put the pre-mixed materials in step (1) into the tank mixer, dry mix for 5-10 minutes, add the slurry prepared in st...

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Abstract

The invention provides a preparation method of betamethasone tablets. The betamethasone tablets comprise an effective treatment dosage of betamethasone, corn starch, saccharose, carboxymethyl starch sodium, sodium dodecyl sulfate, magnesium stearate and povidone K30. The method includes the steps of pulping, mixing, granulating, drying and tabletting. The betamethasone tablets are good in surfaceglossiness and high in hardness, and the process goal is met; the sodium dodecyl sulfate is added, so that the water solubility of the betamethasone tablets is obviously improved on the premise that the chemical structure and the pharmacological action are not changed, and the problems of low dissolution speed and low bioavailability are solved.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a preparation method of betamethasone tablets. Background technique [0002] Betamethasone tablet is a kind of corticosteroid drug, which has various pharmacological effects such as anti-inflammation, anti-allergy, anti-endotoxin and immune suppression. , triamcinolone, etc. are all strong, which can reduce and prevent the response of tissues to inflammation, eliminate the fever, redness and swelling caused by local non-infectious inflammation, thereby reducing the manifestation of inflammation. Now it is mostly used for active rheumatism, rheumatoid arthritis, lupus erythematosus, severe bronchial asthma, severe dermatitis, acute leukemia, etc. It is also used for comprehensive treatment of certain infections. Existing betamethasone tablets have the problems of high cost, loose tablets, uneven surface, and low hardness. Contents of the invention [0003] The purpose of th...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/36A61K47/26A61K47/32A61K47/20A61K31/573A61P29/00A61P19/02A61P37/02A61P11/06A61P17/00A61P35/02A61P31/00
CPCA61K9/2013A61K9/2018A61K9/2027A61K9/2059A61K31/573A61P11/06A61P17/00A61P19/02A61P29/00A61P31/00A61P35/02A61P37/02
Inventor 徐三能强泽明陈永恒陈宝乾张强
Owner 安徽金太阳生化药业有限公司
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