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A kind of kelp paper solid preparation and preparation method thereof

A technology of paper millet and solid preparations, which is applied in the direction of pill delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., to achieve good effects, good fluidity, and improved solubility

Active Publication Date: 2021-07-30
BEIJING ENCHENG KANGTAI BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the polyacrylic resins EPO and E100 mentioned in the patent CN 106333943A are both dissolved in an environment with a pH less than 5 and insoluble in water, they have not been used as solubilizers for comparative research

Method used

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  • A kind of kelp paper solid preparation and preparation method thereof
  • A kind of kelp paper solid preparation and preparation method thereof
  • A kind of kelp paper solid preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] prescription:

[0032] Based on the total amount of 100g, of which:

[0033] Melaleuca paper 30g,

[0034] L-Arginine 3g,

[0035] Bulking agent (mannitol) 60g,

[0036] Disintegrant (croscarmellose sodium) 6g,

[0037] Lubricant (magnesium stearate) 1 g.

[0038] Preparation process: Mix kelp paper, L-arginine, filler and disintegrant evenly, then add appropriate amount of water-based soft material, pass through a 24-mesh sieve to make wet granules, dry, and granulate with a 24-mesh sieve. Lubricant is added, mixed evenly, and then filled into capsules to make capsules.

Embodiment 2

[0040] prescription:

[0041]Based on the total amount of 100g, of which:

[0042] Melaleuca paper 40g,

[0043] L-Arginine 12g,

[0044] Filling agent (pregelatinized starch) 20g,

[0045] Disintegrant (low-substituted hydroxypropyl cellulose) 6g,

[0046] Lubricant (sodium stearyl fumarate) 2g.

[0047] Preparation process: Mix kelp paper, L-arginine, filler and disintegrant evenly, then add appropriate amount of water-based soft material, pass through a 24-mesh sieve to make wet granules, dry, and granulate with a 24-mesh sieve. Lubricant is added to make granules.

Embodiment 3

[0049] prescription:

[0050] Based on the total amount of 100g, of which:

[0051] Melaleuca paper 10g,

[0052] L-Arginine 0.5g,

[0053] Bulking agent (mannitol) 80g,

[0054] Disintegrant (croscarmellose sodium) 8g,

[0055] Lubricant (silicon dioxide) 1.5 g.

[0056] Preparation process: Mix paper pulp with L-arginine and filler evenly, then add appropriate amount of water-based soft material, pass through a 24-mesh sieve to make wet granules, dry, granulate with a 24-mesh sieve, and add a disintegrant and lubricant, mixed evenly and compressed into tablets.

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Abstract

The invention relates to a kelp paper solid preparation and a preparation method thereof, belonging to the field of pharmaceutical preparations. The phyllophyllin solid preparation is composed of the following components by mass percentage: 10-60% phyllophyllin, 0.5-18% L-arginine, 20-80% filler, and 1-10% disintegrant , Lubricant 0‑2%. In the present invention, L-arginine can greatly improve the solubility of phyllophyllin, and compared with other solubilizers, it has good compatibility with phyllophyllin, which can ensure that the prepared solid preparation has good stability . The solid preparation prepared by adopting the technical solution of the invention has the advantages of good fluidity, good compressibility, good dissolution, good drug stability, low processing cost and the like.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a kelp paper solid preparation and a preparation method thereof. Background technique [0002] According to the "World Health Statistical Annual Report" of the World Health Organization, malignant tumors are one of the diseases with the highest mortality rate in the world. For every 100,000 people in the world, the number of deaths due to malignant tumors is about 150. With the increasing morbidity and mortality of global tumor diseases, the research and development of cancer drugs has received more and more attention. The investment proportion of domestic and foreign research institutions and pharmaceutical companies in the research and development of cancer drug technology has been increasing. Statistics show that, At present, 40%-50% of the global new drug research and development investment is used in the research and development of anti-tumor drugs, which also makes ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61K47/18A61K9/20A61K9/16A61K9/48A61P35/00
CPCA61K9/1617A61K9/2013A61K31/352A61K47/183
Inventor 孙艳玉隋鹏张晟源
Owner BEIJING ENCHENG KANGTAI BIOLOGICAL TECH
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