Nasal nano-emulsion in-situ gel for treating hydrocephalus, and preparation method of nasal nano-emulsion in-situ gel

Abstract

The invention relates to nasal nano-emulsion in-situ gel for treating hydrocephalus, and a preparation method of the nasal nano-emulsion in-situ gel. The nasal nano-emulsion in-situ gel can effectively solve the problems that the traditional oral preparation is poorer in target ability and lower in bioavailability when being used for treating the cerebral diseases, thus limiting the application oftraditional Chinese medicines in treatment of the diseases such as the hydrocephalus to a certain extent. In order to solve the problems, the technical scheme is adopted; the nasal nano-emulsion in-situ gel is prepared from the following raw material medicines by weight: 20-100g of flos magnoliae, 15-75g of rhizoma acori graminei, 20-100g of herba lycopi, 12-60g of fructus xanthii, 15-75g of radix sophorae flavescentis, 15-75g of radix salviae miltiorrhizae, 10-50g of rhizoma chuanxiong, 15-75g of muskmelon pedicel, 3-9g of borneol, 10-30g of mirabilite, 1-3g of musk, 2-10g of storax, 12.786-63.93g of anhydrous ethanol, 20.586-102.93g of castor oil polyalkoxy ester (35), 4.176-20.88g of ethyl oleate, 21-105g of poloxamer 407 and 18-90g of poloxamer 188. The nasal nano-emulsion in-situ gelhas the advantages of nano-emulsion and in-situ gel at the same time, and not only can improve the solubility, transdermal rate and targeting effect of the medicines, but also can reduce the irritation of the medicines, thus being an innovation in medicines for treating the hydrocephalus.

Description

technical field [0001] The invention relates to medicine, in particular to a nasal nanoemulsion in-situ gel for treating hydrocephalus and a preparation method thereof. Background technique [0002] Hydrocephalus is a disease caused by the abnormal increase of cerebrospinal fluid in the brain caused by the imbalance in the production and absorption of cerebrospinal fluid, the expansion of the ventricular system or the expansion of the subarachnoid space due to craniocerebral diseases. Some data show that the incidence of hydrocephalus in the general population is 1% to 1.5%, and it increases with the growth of the population. It has the characteristics of high incidence, high disability and high mortality. Its classification and etiology are complex, and there is currently no unified and standardized treatment plan. Western medicine treats severe hydrocephalus with cerebrospinal fluid shunt as the main method, but this method is not suitable for all cases, and it is expensi...

AI Technical Summary

Problems solved by technology

[0003] In view of the above situation, in order to solve the defects of the prior art, the purpose of the present invention is to provide a nasal nanoemulsion in situ gel for the treatment of hydrocephalus and its preparation method, which can effectively solve the problem of traditional oral preparations for the treatment of brain diseases. Poor tropism and low bioavailability limit the application of traditional Chinese medicine in hydrocephalus and other diseases to a certain extent