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Aluminum-free composition for inhibiting bromhidrosis

A composition and technology for underarm odor, applied in the field of biomedicine, can solve the problems of affecting the nervous system, uncertain safety, allergies, etc.

Pending Publication Date: 2019-08-16
赵叶莲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, most antiperspirant drugs on the market are antiperspirants, which inhibit the generation of underarm odor by inhibiting the sweating of the apocrine glands in the underarms. The main antiperspirants are basic aluminum chloride or basic aluminum zirconium chloride. The disadvantages of antiperspirants are: 1) The mechanism is unknown; 2) Aluminum may affect the nervous system, and there is uncertain safety; 3) There are side effects such as skin darkening or allergies

Method used

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  • Aluminum-free composition for inhibiting bromhidrosis
  • Aluminum-free composition for inhibiting bromhidrosis
  • Aluminum-free composition for inhibiting bromhidrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Mix according to the ratio, put it into a spray bottle, and make it a spray. This formulation is transparent and stable.

Embodiment 2

[0062] Glycyrrhetinic acid (GA), 1-deoxynojirimycin (1-DNJ), cetearyl ether-6 (A6), cetearyl alcohol / cetearyl ether-25 ( A25), fatty acid sucrose ester (SE), lauryl lactate (LA20), PGCC, Spectrastat PHL, azone, vitamin E (VE), triethanolamine, glycerin, absolute ethanol are mixed until fully dissolved, and lysine Add it to 10% soluble monoligand zinc salt solution to dissolve, then add it to the previous mixed solution, stir for half an hour to obtain a transparent microemulsion, put it into a spray bottle, and use it as a spray.

Embodiment 3

[0064] According to the ratio, glycyrrhetinic acid (GA), 1-deoxynojirimycin (1-DNJ), CO40, lauryl lactate (LA20), Spectrastat PHL, azone, vitamin E (VE), triethanolamine, glycerin , absolute ethanol until completely dissolved, and lysine was added to 10% soluble monoligand zinc salt solution to dissolve, and then added to the previous mixed solution, stirred for half an hour to obtain a transparent microemulsion, loaded into In a spray bottle, it is a spray.

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PUM

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Abstract

The invention relates to an aluminum-free composition for inhibiting bromhidrosis. The aluminum-free composition uses 0.01-5% of pentacyclic triterpene compound monomer or monomer composition, 0.5-10%of soluble single-ligand or multi-ligand zinc salt and 0-5.0% of 1-deoxynojirimycin or derivative thereof as the main active components. The aluminum-free composition inhibits the bromhidrosis by inhibiting body odor precursor transfer, killing bacteria capable of decomposing body odor precursors and inhibiting axillary apocrine gland sweat secretion. The aluminum-free composition is clear in component and mechanism, safe in long-term use, quick in action, good in effect, lasting in effect and the like.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to the use of compositions such as pentacyclic triterpenes and zinc salts in preparing medicines for treating underarm odor. Background technique [0002] Underarm odor, which smells bad and stains clothes, is a distressing and troublesome problem. Some people show fear, disgust, or psychological sensitivity to unpleasant smells, and even lead to some people's olfactory phobia. Underarm odor seriously affects work, life and social interaction. Underarm odor is considered a disease in Japan and is covered by national health insurance. Underarm odor is about 20% among Chinese and other Asians. [0003] At present, most antiperspirant drugs on the market are antiperspirants, which inhibit the generation of underarm odor by inhibiting the sweating of the apocrine glands in the underarms. The main antiperspirants are basic aluminum chloride or basic aluminum zirconium chloride. The disadvanta...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K33/30A61P17/00A61K31/56A61K31/445
CPCA61K45/06A61K31/56A61P17/00A61K45/00A61K2300/00
Inventor 赵叶莲
Owner 赵叶莲
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