A clam polysaccharide with immune-enhancing activity, its preparation method and application

A technology for enhancing immunity and green clams, applied in the application field of functional food or medicine, can solve problems such as limited sources
CN110128560BActive Publication Date: 2021-03-09DALIAN POLYTECHNIC UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
DALIAN POLYTECHNIC UNIVERSITY
Publication Date
2021-03-09

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Abstract

The invention discloses a clam polysaccharide with enhanced immune activity, the main chain of the clam polysaccharide is composed of →4)-α-D-Glcp(1→, in the structure of the polysaccharide →4)Glc( 1→and→4,6)Glc(1→The ratio is 6.8:1, the molecular weight is 380KDa, and the monosaccharide composition is mannose:glucose=1:35; using green clam as raw material, after degreasing, enzymatic hydrolysis, complex combined precipitation, alcohol precipitation to remove impurities, and DEAE-cellulose column purification to obtain clam polysaccharide; the obtained clam polysaccharide can promote the production of NO by RAW 264.7 cells, and the clam polysaccharide is within the range of 1 to 10 μg / mL It can significantly improve the NO secretion ability of RAW 264.7 cells and is positively correlated with the dose; the clam polysaccharide can be used as an important source for the development of immunomodulatory drugs and functional foods, and provides theoretical basis and practical guidance for the high-value transformation of marine shellfish.
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Description

technical field

[0001] The invention relates to the technical field of active polysaccharides, in particular to a clam polysaccharide with immune-enhancing activity, an extraction method and its application in immune-enhancing functional foods or medicines. Background technique

[0002] Green clam (Cyclina sinensis), also known as black clam, iron clam, round clam, clam, ox-eye clam, is widely distributed in Liaoning, Hebei, Shandong, Jiangsu, Zhejiang, Fujian, Guangdong, Guangxi and Hainan Island. The common and main edible bivalve molluscs in the north and south coasts occupy an important economic position in the tidal flat shellfish farming in my country. Green clam not only has edible value, but also has medicinal value, and is a very important marine drug; "Shen Nong's Herbal Classic" and "Compendium of Materia Medica" all include green clam as a commonly used drug. Green clam has high nutritional and medicinal value, so the development and utilization of green clam res...

Claims

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