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Preparation method of chitosan-pullulan electrostatic spinning composite nanofiber membrane

A technology of composite nanofibers and pullulan, applied in textiles, papermaking, non-woven fabrics, etc., can solve the problems of low spinnability of chitosan, hindering fiber formation, and limiting the application of chitosan nanofibers, etc. Achieve the effect of improving spinnability, avoiding the use of toxic reagents, and improving biocompatibility

Inactive Publication Date: 2019-08-16
NORTHEAST AGRICULTURAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the repulsion between ions on the chitosan backbone under high electrostatic voltage, the formation of fibers is hindered.
The spinnability of chitosan is not high
The current method to solve this difficulty mainly includes two aspects: one is to dissolve chitosan in organic solvents such as trifluoroacetic acid; This method involves the use of toxic reagents, which greatly limits the application of chitosan nanofibers in the fields of food and medicine

Method used

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  • Preparation method of chitosan-pullulan electrostatic spinning composite nanofiber membrane
  • Preparation method of chitosan-pullulan electrostatic spinning composite nanofiber membrane
  • Preparation method of chitosan-pullulan electrostatic spinning composite nanofiber membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Weigh 4 g of chitosan with a molecular weight of 400,000 in 80 ml of 50% acetic acid aqueous solution, and magnetically stir for 8 hours to obtain a uniform and stable transparent solution.

[0031] (2) Weigh 6 g of pullulan with a molecular weight of 200,000 in 20 ml of 50% acetic acid aqueous solution, and stir magnetically for 6 hours to obtain a stable transparent solution.

[0032] (3) Mix the solutions obtained in steps (1) and (2), and magnetically stir for 4 hours to obtain a uniform and stable transparent solution. This solution total polymer mass fraction is 10%, and the ratio of chitosan and pullulan is 40:60, and the concentration of chitosan this moment is the maximum ratio of preparation chitosan solution, exceeds this ratio, and solution is transformed into gel.

[0033] (4) Inhale the solution obtained in step (3) into a 10ml syringe, install a needle with a diameter of 0.8mm, control the flow rate at 0.5ml / h, adjust the distance from the needle to ...

Embodiment 2

[0035] (1) Weigh 3 g of chitosan with a molecular weight of 400,000 in 60 ml of 50% acetic acid aqueous solution, and magnetically stir for 8 hours to obtain a uniform and stable transparent solution.

[0036] (2) Weigh 7 g of pullulan with a molecular weight of 200,000 into 40 ml of 50% acetic acid aqueous solution, and stir magnetically for 6 hours to obtain a stable transparent solution.

[0037] (3) Mix the solutions obtained in steps (1) and (2), and magnetically stir for 4 hours to obtain a uniform and stable transparent solution. The total polymer mass fraction of the solution is 10%, and the ratio of chitosan to pullulan is 30:70.

[0038] (4) Inhale the solution obtained in step (3) into a 10ml syringe, install a needle with a diameter of 0.8mm, control the flow rate at 0.5ml / h, adjust the distance from the needle to the receiver to be 10cm, and set the voltage to 15kv. Spinning under normal pressure for 5 hours, and then drying at room temperature for 3 hours to obt...

Embodiment 3

[0040] (1) Weigh 2 g of chitosan with a molecular weight of 400,000 in 55 ml of 50% acetic acid aqueous solution, and magnetically stir for 8 hours to obtain a uniform and stable transparent solution.

[0041] (2) Weigh 8 g of pullulan with a molecular weight of 200,000 in 45 ml of 50% acetic acid aqueous solution, and stir magnetically for 6 hours to obtain a stable transparent solution.

[0042] (3) Mix the solutions obtained in steps (1) and (2), and magnetically stir for 4 hours to obtain a uniform and stable transparent solution. The total polymer mass fraction of the solution is 10%, and the ratio of chitosan to pullulan is 20:80.

[0043] (4) Inhale the solution obtained in step (3) into a 10ml syringe, install a needle with a diameter of 0.8mm, control the flow rate at 0.5ml / h, adjust the distance from the needle to the receiver to be 10cm, and set the voltage to 15kv. Spinning under normal pressure for 5 hours, and then drying at room temperature for 3 hours to obtai...

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Abstract

The invention relates to the field of preparation of composite nanofiber membranes, in particular to a preparation method of a chitosan-pullulan electrostatic spinning composite nanofiber membrane. The preparation method comprises steps as follows: chitosan and pullulan are dissolved in an acetic acid aqueous solution respectively and stirred, and transparent solutions are obtained; a pullulan solution and a chitosan solution are mixed in a certain proportion and stirred, and a spinning solution is obtained; the spinning solution is subjected to electrospinning by electrospinning equipment inthe normal-temperature and normal-pressure environment, and the nanofiber membrane is obtained. The spinning aiding capability of pullulan is mainly used, the defect of low probability of spinning ofchitosan is overcome, the natural and edible polysaccharide composite nanofiber membrane with good biocompatibility and heat stability is prepared, and the preparation method is simple and convenientto operate.

Description

technical field [0001] The invention relates to the field of preparation of composite nanofiber membranes, in particular to a method for preparing chitosan-pullulan electrostatic spinning composite nanofiber membranes. Background technique [0002] Nanofibers have a large specific surface area, unique mechanical, optical, electrical, thermal and surface properties, so that they can be widely used in the fields of biopharmaceuticals, filtration, food, textiles and electronics after functionalization. Electrospinning technology is currently the only spinning technology that can continuously and effectively prepare nanofibers. Its advantages include the following aspects: for example, no heating is required in the production process, simple operation, and low cost. Therefore, the use of electrospinning technology to prepare nanofibers has become a research hotspot in recent years. [0003] Compared with synthetic polymers, natural polymers have better biocompatibility, biodegr...

Claims

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Application Information

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IPC IPC(8): D04H1/728D04H1/4382
CPCD04H1/4382D04H1/728
Inventor 王浩秦泽宇孔保华
Owner NORTHEAST AGRICULTURAL UNIVERSITY
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