Extractive preparation method of sinomenine hydrochloride in orienavine

Abstract

The invention provides an extractive preparation method of sinomenine hydrochloride in orienavine. The active component sinomenine in orienavine is converted to sinomenine hydrochloride under the condition of low-concentration hydrochloric acid, and water solubility is improved such that pure water can be used as a solvent. The active component sinomenine hydrochloride is dissolved out from orienavine by a leaching method; and pH of a leaching solution is regulated with alkali lye firstly, and then a flocculating agent is added to precipitate vegetable protein in the leaching solution step bystep. In the extractive preparation technology of sinomenine hydrochloride, working concentration of acid and alkali is reduced, sinomenine hydrochloride is prevented from being decomposed in the environment of high-concentration acid and alkali, and generation of new impurities in the final product is reduced. Yield of sinomenine hydrochloride prepared by the above method can reach 1.5% and aboveof yield of orienavine.

Description

[0001] 【Technical field】 [0002] The invention belongs to the technical field of pharmacy, and in particular relates to a preparation method for extracting sinomenine hydrochloride from Teng teng. [0003] 【Background technique】 [0004] Sinomenine hydrochloride has pharmacological effects such as anti-inflammatory, analgesic, antihypertensive and antiarrhythmic. At present, many preparations have been used clinically for the treatment of rheumatism and rheumatoid arthritis. [0005] Traditional sinomenine hydrochloride mostly adopts alkalization water extraction process, which is to add water and a certain amount of slaked lime to the root of ivy, alkalize for a period of time, then add a certain amount of industrial benzene, reflux extraction in a water bath, and then acidify and stand , Crystallization. This method uses a large amount of organic benzene as the extraction solvent. In terms of solvent recovery and treatment, cumbersome processes are required to meet environm...

AI Technical Summary

Problems solved by technology

In wetting, impregnation and percolation, if the concentration of hydrochloric acid (HCl) is controlled within this range, especially when the concentration of hydrochloric acid is greater than 0.3mol.L -1 When the concentration of hydrochloric acid is too high, it is easy to cause the acid decomposition of sinomenine, and other impurities dissolved by acid from S. sinensis will also increase due to the high concentration of acid; , the latter step needs to use milk of lime to neutralize hydrochloric acid, resulting in a large amount of alkali consumption and difficult wastewater treatment;

[0008] Moreover, the patent uses the percolation method to extract sinomenine hydrochloride from C. chinensis, and there is a problem that the percolation cylinder will be blocked after the C. chinensis is crushed, so that the percolation cannot be carried out;

[0009] Furthermore, the invention patent uses high-concentration milk of lime, that is, Ca(OH) 2 Saturated solution, adjust the pH of the percolation solution to 10.5-12, because the dissolving and dispersibility of milk of lime is not good, the pH of the adjusted solution is too high, and the alkali decomposition of sinomenine hydrochloride is prone to occur, resulting in the loss of sinomenine hydrochloride or the addition of new Impurities

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