Ergosterol compounds with anti-inflammatory activity, and preparation method and application thereof

An ergosterol and compound technology, applied in the preparation of anti-inflammatory drugs, the ergosterol compound and the preparation field thereof, can solve the problems such as no ergosterol compound NO inhibitor, etc.
CN110143992AInactive Publication Date: 2019-08-20KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
Publication Date
2019-08-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses ergosterol compounds with anti-inflammatory activity, and the ergosterol compounds are from Ganoderma sinensis and are as shown in a structural formula which is described in the specification. The invention also discloses a preparation method for the compounds and application of the compounds in pharmacy. The compounds can be applied as NO inhibitors to the preparation of anti-inflammatory drugs.
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Description

technical field

[0001] The invention belongs to the technical field of medicines, and in particular relates to ergosterol compounds extracted and separated from Zizhi lucidum, a preparation method thereof and their application as NO inhibitors in the preparation of anti-inflammatory drugs. Background technique

[0002] Nitric oxide (NO) is a chemical substance with biological regulation function, which has important reference and application value in the research of inflammation. Studies have shown that when macrophages are stimulated by toxins, inflammatory mediators, etc., it will lead to a large amount of nitric oxide synthase (iNOS), and nitric oxide synthase (iNOS) catalyzes the L-arginine in its substrate , produce NO as the main product of the immune response, so the amount of NO produced in the screening of inflammatory activity can be used as an important indicator of the anti-inflammatory activity of the test drug. LPS-induced mouse macrophages (RAW 264.7) were us...

Claims

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