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Nano emulsion based curcumin hydrogel sphere and preparation method thereof

A nano-emulsion and curcumin technology, applied in the field of carrier systems in medicine and food preparation technology, can solve the problems of poor water solubility and low stability of curcumin, and achieve the effect of improving water solubility and stability

Pending Publication Date: 2019-08-23
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Technical problem: The present invention aims at proposing a method for preparing curcumin hydrogel balls based on nanoemulsions to solve the problems of poor water solubility and low stability of curcumin

Method used

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  • Nano emulsion based curcumin hydrogel sphere and preparation method thereof
  • Nano emulsion based curcumin hydrogel sphere and preparation method thereof
  • Nano emulsion based curcumin hydrogel sphere and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A curcumin hydrogel ball based on nanoemulsion. The hydrogel ball uses calcium ions as a cross-linking agent and contains the following components:

[0033]

[0034]

[0035] The preparation method of the curcumin hydrogel ball based on nanoemulsion is as follows:

[0036] 1. Weigh 6g of medium-chain triglycerides, 2g of vitamin E acetate, 4g of decaglycerol monooleate, 2g of Tween 80, and 2g of polyglycerol castor oil ester in a 150mL beaker, and place it in a water bath at 75°C. Stir at a speed of 400r / min until uniform, as the mixed oil phase;

[0037] 2. Weigh 0.3g curcumin powder and add it to the oil phase, stir at 75°C and 400r / min until it is completely dissolved, then add 0.6g polyethylene glycol 400, and stir evenly at 75°C and 400r / min to obtain a homogeneous system;

[0038] 3. Weigh 83.1g of deionized water into a 100mL Erlenmeyer flask with stopper, preheat it in a 75℃ water bath, pour the preheated deionized water into the homogeneous system at one time, stir at ...

Embodiment 2

[0043] A curcumin hydrogel ball based on nanoemulsion. The hydrogel ball uses calcium ions as a cross-linking agent and contains the following components:

[0044]

[0045] The preparation method of the curcumin hydrogel ball based on nanoemulsion is as follows:

[0046] 1. Weigh 10g of medium chain triglycerides, 5g of corn oil, 8g of decaglycerol monolaurate, 4g of Tween 80, and 60 3g of phosphatidylcholine in a 150mL beaker, and place it in a 75℃ water bath at 400r / min Stir at a speed of 1 to be uniform, as the mixed oil phase;

[0047] 2. Weigh 1g curcumin powder and add it to the oil phase, stir at 75°C and 400r / min until it is completely dissolved, then add 1g calcium stearate, and stir evenly at 75°C and 500r / min to obtain a homogeneous system;

[0048] 3 Weigh 68g of deionized water in a 100mL Erlenmeyer flask with stopper, preheat it in a 75℃ water bath, pour the preheated deionized water into the homogeneous system at one time, and stir at 75℃ and 500r / min until it is comple...

Embodiment 3

[0053] A curcumin hydrogel ball based on nanoemulsion. The hydrogel ball uses calcium ions as a cross-linking agent and contains the following components:

[0054]

[0055] The preparation method of the curcumin hydrogel ball based on nanoemulsion is as follows:

[0056] 1. Weigh 13g caprylic acid glycerides, 7g medium-chain triglycerides, 14g Tween 80, and phosphatidylcholine 60 3g in a 150mL beaker. Place them in a 75℃ water bath and stir at a speed of 400r / min until uniform. As a mixed oil phase;

[0057] 2. Weigh 1g curcumin powder and add it to the oil phase, stir at 75°C, 400r / min until it is completely dissolved, then add 1.2g povidone K30, stir evenly at 75°C, 500r / min to obtain a homogeneous system;

[0058] 3. Weigh 60.8g of deionized water into a 100mL conical flask with stopper, preheat it in a 75℃ water bath, pour the preheated deionized water into the homogeneous system at one time, and stir at 75℃, 500r / min Until it is fully emulsified, cool to room temperature to obta...

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Abstract

The invention discloses a nano emulsion based curcumin hydrogel sphere and a preparation method thereof. The hydrogel sphere comprises, by mass, 0.3-1.5 parts of curcumin, 8-20 parts of liquid lipid,8-18 parts of an emulsifier, 0.6-2 parts of a dispersing agent, 0.6-1.2 parts of sodium alginate and 60-85 parts of deionized water. The preparation method includes the following steps that 1, stablecurcumin nano emulsion is prepared; 2, sodium alginate powder is added into the curcumin nano emulsion to obtain sodium alginate-curcumin nano emulsion; 3, the sodium alginate-curcumin nano emulsion is dropwise added into a calcium chloride solution, cross-linked, taken out and washed to remove surface impurities, and the curcumin hydrogel sphere is obtained. The water solubility and stability ofcurcumin can be improved, the operation is simple, the repeatability is good, and obtained gel keeps a stable spherical structure, is uniform and attractive and can be applied to various fields.

Description

Technical field [0001] The invention relates to a curcumin hydrogel ball based on nanoemulsion and a preparation method thereof, and belongs to the technical field of carrier systems in medicine and food preparation technology. Background technique [0002] Curcumin (3-methoxy-4-hydroxy-phenyl-1,6-heptadiene-3,5-dione) is a kind of plant extracted from Zingiberaceae and Araceae. It belongs to β- Polyphenols with diketone functional groups, molecular formula C 21 H 20 O 6 , The relative molecular weight is 368.39. The pure product is orange-yellow crystalline powder, insoluble in water, soluble in methanol, ethanol, acetone and glacial acetic acid. Recent studies have found that curcumin has broad pharmacological activities such as anti-inflammatory, anti-oxidant, lipid-regulating, anti-viral, anti-infective, anti-tumor, anti-coagulation, anti-hepatic fibrosis, anti-atherosclerosis, etc., and has a wide range of pharmacological activities against rodents. And the human side effe...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K9/107A61K31/12A61K47/36A61K47/44A61P29/00A61P39/06A61P3/06A61P31/12A61P31/00A61P35/00A61P1/16A61P9/10A61P7/02
CPCA61K9/06A61K9/1075A61K31/12A61K47/36A61K47/44A61P29/00A61P39/06A61P3/06A61P31/12A61P31/00A61P35/00A61P1/16A61P9/10A61P7/02
Inventor 夏强马愈迪
Owner SOUTHEAST UNIV
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