A method for preparing 3-nitrile ethyl-2-hydrocarbyl-4h-benzoxazine by bromoacetonitrile under blue light irradiation conditions
A technology of benzoxazine and irradiation conditions, which is applied in the field of functionalization/cyclization reaction of alkenyl-containing compounds, can solve problems such as post-processing troubles, achieve mild reaction conditions, wide applicability, and simple and easy-to-obtain reaction raw materials Effect
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Embodiment 1
[0023] Embodiment 1: prepare 4-methyl-2-phenyl-4-nitrile ethyl-(4 H )-1,3-Benzoxazine (3a)
[0024] (3-(4-methyl-2-phenyl-4H-benzo[d][1,3]oxazin-4-yl)propanenitrole)
[0025]
[0026] In the dried Schlenk tube, add the amide raw material N-(2-isopropenylphenyl)benzamide (0.1 mmol, 23.7 mg), base: K 3 PO 4 (0.2 mmol, 42.4 mg), catalyst: tris(2-phenylpyridine) iridium Ir(ppy) 3 (0.002 mmol, 1.3 mg), bromoacetonitrile (0.2 mmol, 24 mg), acetonitrile 1 mL, replace the gas in the reaction tube with nitrogen three times, and finally fill the reaction tube with nitrogen, and place the above Schlenk tube in a 16 W blue Stir for 24 h under LED light irradiation. The reaction was terminated, and the reaction solution was quenched with 2 mL of saturated ammonium chloride, and extracted several times with ethyl acetate (4 mL × 5). The organic phases were combined, and the solvent was removed on a rotary evaporator. Finally, it was separated by silica gel column chromatography (eluen...
Embodiment 2
[0028] Embodiment 2: Preparation of 4-methyl-2-phenyl-4-nitrile ethyl-(4 H )-1,3-Benzoxazine (3a)
[0029] (3-(4-methyl-2-phenyl-4H-benzo[d][1,3]oxazin-4-yl)propanenitrole)
[0030]
[0031] In the dried Schlenk tube, add the amide raw material N-(2-isopropenylphenyl)benzamide (0.1 mmol, 23.7 mg), base: K 2 CO 3 (0.2 mmol, 27.6 mg), catalyst: tris(2-phenylpyridine) iridium Ir(ppy) 3 (0.002 mmol, 1.3 mg), bromoacetonitrile (0.2 mmol, 24 mg), acetonitrile 1 mL, replace the gas in the reaction tube with nitrogen three times, and finally fill the reaction tube with nitrogen, and place the above Schlenk tube in a 16 W blue Stir for 24 h under LED light irradiation. The reaction was terminated, and the reaction solution was quenched with 2 mL of saturated ammonium chloride, and extracted several times with ethyl acetate (4 mL × 5). The organic phases were combined, and the solvent was removed on a rotary evaporator. Finally, it was separated by silica gel column chromatograp...
Embodiment 3
[0032] Embodiment 3: Preparation of 4-methyl-4-nitrile ethyl-2-(p-tolyl)-(4 H )-1,3-Benzoxazine (3b)
[0033] (3-(4-methyl-2-(p-tolyl)-4H-benzo[d][1,3]oxazin-4-yl)propanenitrole)
[0034]
[0035] In the dried Schlenk tube, add the amide raw material N-(2-isopropenylphenyl)-p-benzamide (0.1 mmol, 25.1 mg), base: K 3 PO 4 (0.2 mmol, 42.4 mg), catalyst: tris(2-phenylpyridine) iridium Ir(ppy) 3 (0.002 mmol, 1.3 mg), bromoacetonitrile (0.2 mmol, 24 mg), acetonitrile 1 mL, replace the gas in the reaction tube with nitrogen three times, and finally fill the reaction tube with nitrogen, and place the above Schlenk tube in a 16 W blue Stir for 24 h under LED light irradiation. The reaction was terminated, and the reaction solution was quenched with 2 mL of saturated ammonium chloride, and extracted several times with ethyl acetate (4 mL × 5). The organic phases were combined, and the solvent was removed on a rotary evaporator. Finally, after separation by silica gel column chr...
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