33 results about "Bromoacetonitrile" patented technology

The invention discloses a method and a product for preparing carbon dots by using bromoacetonitrile and imidazole compounds, specifically mixing bromoacetonitrile and 1-methylimidazole and directly reacting to prepare carbon dots. The synthesis process of the method of the invention is simple and green, and the synthesized carbon dots have good fluorescence performance and light stability, and provide a new method for the synthesis of carbon dots.

The invention relates to an industrial preparation method of a cis-3-amino-2-arylpyrrolidine derivative, which mainly solves the technical problems that the synthetic route is long, the yield is low, the cost is high, the obtained cis-product content is low, the post treatment operation is difficult, the intermediate compound is difficult to purify, the reaction conditions are severe and large-scale production can not be realized in the existing cis-3-amino-2-arylpyrrolidine compound synthesis. The preparation method comprises the following steps: under the action of sodium hydride, condensing conventional and readily accessible aryl methyl ketone used as an initial raw material and dimethyl carbonate in a tetrahydrofuran solution, and performing bromoacetonitrile alkylation, Raney nickel hydrogenated cyclization and enamine hydrogenated reduction to obtain (cis)-2-(substituted phenyl)-pyrrolidine-3-carboxylate; and then, adding protective groups, performing acid hydrolysis, rearranging, and removing Boc groups to obtain the target product cis-3-amino-2-arylpyrrolidine derivative. The process provided by the invention is simple, has the advantages of fewer reaction steps, high gross production rate and mild conditions, avoids the use of expensive and dangerous reagents, can realize scale-up production and is easy to realize industrial operation.

The invention discloses a preparation method for a cyanomethylation imidazopyridine compound. The preparation method comprises the steps of using an imidazo[1,2-a]pyridine compound as a raw material, and enabling the imidazo[1,2-a]pyridine compound to react with bromoacetonitrile or iodoacetonitrile under photocatalysis to obtain the cyanomethylation imidazopyridine compound. Compared with the prior art, the method disclosed by the invention avoids using highly toxic products such as potassium cyanide, sodium cyanide or methyl iodide; and in the process of preparing a cyanomethylation product of the imidazo[1,2-a]pyridine compound, the original three steps are cut down to one step in chemical conversion. According to the preparation method disclosed by the invention, the preparation route is short; the preparation method is simple; the production cost is low; the yield of products is high; the use of a solvent and pollution caused to the environment during pollution discharge are reduced; the implementation is easy; and the industrialization is convenient to realize.

The invention discloses a preparation method of an agomelatine intermediate. The preparation method comprises steps as follows: firstly, 1-bromo-7-methoxynaphthalene is dissolved in an organic solvent, and a mixed solution is formed; elementary alkali metal and an initiator are added to a reaction bottle, the organic solvent is added to the reaction bottle and stirred uniformly, the prepared mixed solution is dropwise added slowly, when a reaction liquid is boiled slightly, the organic solvent is supplemented into the reaction bottle and stirring is started, the prepared mixed solution is dropwise added continuously, and a reaction liquid of a 1-bromo-7-methoxynaphthalene Grignard reagent is obtained after the heat preservation reaction; bromoacetonitrile is added to the organic solvent, a bromoacetonitrile mixed liquid is prepared, the prepared bromoacetonitrile mixed liquid is dropwise added slowly to the reaction liquid of the Grignard reagent, and (7-methoxy-1-naphthyl) acetonitrile is obtained after the heat preservation reaction and aftertreatment. With the adoption of the method, industrial production can be realized, 1-bromo-7-methoxynaphthalene is taken as a starting material, the cost can be saved, the product quality is stable, the yield is high, and the preparation method is applicable to large-scale industrial stable production.

A synthetic method for 6-chloroimidazo[1,2-b]pyridazine-3-carbonitrile, comprising the steps of: Step 1: adding N,N-dimethylformamide dimethyl acetonitrile to the reactor Aldehyde reacts with 3-amino-6-chloropyridazine to obtain N,N-dimethyl-N'-3-(6-chloro-pyridazin) base-formamidine intermediate; step 2: the resulting N,N-dimethyl-N'-3-(6-chloro-pyridazine) base-formamidine intermediate is mixed with solvent, added bromoacetonitrile, reacted, added lye, left standing, precipitated solid, filtered, and obtained Solid mixture; Step 3: The solid mixture obtained in Step 4 is completely dissolved in ethyl acetate, washed with water and saturated brine, dried, filtered, and ethyl acetate is removed to obtain 6-chloroimidazo[1,2-b] Pyridazine‑3‑carbonitrile crude product; step 4: recrystallize 6‑chloroimidazo[1,2‑b]pyridazine‑3‑carbonitrile crude product, filter to obtain 6‑chloroimidazo[1,2‑b ] Pyridazine‑3‑carbonitrile pure product. The whole process of the invention is short in time, and the obtained product has stable quality and high purity.

The invention relates to a method for preparing high-purity Gadobutrol. The method uses 3-(1,4,7,10-tetraazacyclododecane-1-yl)butane-1,2,4-triol to react with bromoacetonitrile or bromoacetamide, anobtained intermediate is hydrolyzed under an alkaline condition, and a hydrolysate is complexed with a gadolinium ion source to obtain the high-purity Gadobutrol. The preparation process of the methodis simple and mild, and the method is suitable for large-scale process production.

The invention discloses a method for preparing dicyanomethyl phenylphosphine, which comprises the following steps of: adding tetrahydrofuran and zinc powder into a reactor, adding dropwise the mixed solution of dichlorophenylphosphine, bromoacetonitrile and the tetrahydrofuran, performing reaction at the constant temperature of 20 to 70 DEG C for 0.5 to 3 hours, performing primary distillation under reduced pressure to recover the tetrahydrofuran and the bromoacetonitrile after the reaction is finished, continuing to add dichloromethane and water into the distilled reactor, performing demixing under stirring to obtain an organic layer, and performing secondary distillation under reduced pressure to remove the dichloromethane to obtain the dicyanomethyl phenylphosphine finished product. The dicyanomethyl phenylphosphine product prepared by the method has the purity of over 98 percent; and the production process is simple, the production is easy to control and the method is favorable for large-scale production.

The invention discloses a method for preparing 3-nitrile ethyl-2-hydrocarbyl-4H-benzoxazine from bromoacetonitrile under the condition of blue light irradiation, and belongs to the technical field of alkenyl difunctionalization. Add tris(2-phenylpyridine)iridium, potassium phosphate or potassium carbonate, N-[2-isoenylaryl]amide, bromoacetonitrile, and solvent to the treated Schlenk tube, and place the Schlenk tube under nitrogen atmosphere. Stir under blue LED light for 24 hours. The reaction solution was terminated by saturated brine, then extracted, and the product was obtained by column chromatography. The present invention uses bromoacetonitrile as the source of nitrile methyl group for the first time, and constructs 3-nitrile ethyl-2-hydrocarbyl-4H-benzoxazine compound under the condition of blue LED light irradiation. The method has the advantages of simple and easy-to-obtain reaction raw materials and catalysts, no need for excessive oxidants and equivalent copper salts, mild reaction conditions, high product yield, simple operation and post-treatment processes, and the like.

The invention belongs to the chemical synthesis field, and specifically relates to a preparation method of (E)-oct-4-ene-1,8-diacid. The preparation method comprises the following steps: taking bromoacetonitrile as a starting raw material, reacting with a metal element to obtain a metal composite of bromoacetonitrile, and preparing (E)-oct-4-ene-1,8-dinitrile from the metal composite and 1,4-dibromo-2-butene; and hydrolysing (E)-oct-4-ene-1,8-dinitrile to obtain (E)-oct-4-ene-1,8-diacid. According to the method disclosed by the invention, the starting material is cheap and easily available, and a product with purity of 99% or higher can be obtained by simple post-treatment steps such as liquid-separation extraction and concentration after first-step reaction, and simple extraction after hydrolysing cyano alkali into carboxylic acid or hydrolysing cyan acid into ester in the second step. The process reaction and post-treatment operation are simple, and the obtained product is high in quality, so that using requirements can be met without further purification. The preparation method adopts an environment-friendly process, is economical and practical, and is very suitable for industrial production.