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A Method for Improving the Degradability of Hydroxyapatite by Electron Irradiation

A technology of hydroxyapatite and electron irradiation, which is used in material analysis, material excitation analysis, and instrumentation using wave/particle radiation, which can solve the complex experimental process of modification technology, slow degradation rate of hydroxyapatite, and introduction of Heterogeneous ions and other problems, to achieve the effect of large-scale production, significant modification effect, and increase the degree of degradation

Active Publication Date: 2020-07-28
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to provide a method for improving the degradability of hydroxyapatite by electron irradiation, which is easy to operate and solves the problem that the degradation rate of hydroxyapatite is too slow. Introduce defects such as heterogeneous ions

Method used

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  • A Method for Improving the Degradability of Hydroxyapatite by Electron Irradiation
  • A Method for Improving the Degradability of Hydroxyapatite by Electron Irradiation
  • A Method for Improving the Degradability of Hydroxyapatite by Electron Irradiation

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Embodiment 1

[0041] In this embodiment, the method for improving the degradability of apatite by electron irradiation comprises the following steps:

[0042] a. Put the HA powder into a φ13 tableting mold, use a hydraulic tableting machine to apply pressures of 1.5t, 2.0t, and 2.5t respectively and keep the pressure for half a minute. After demoulding, the diameter is 13mm and the height is 1.93mm. , 2.00mm and 2.07mm small wafers. Subsequently, the small discs were placed in a muffle furnace for heat treatment at 400 °C for 1 h to obtain HA block samples.

[0043] b. Transfer the HA block sample to a copper irradiated sample box with a height of 2 mm, place it evenly on the sample stage, and fix it with copper glue. The HA block sample is located directly below the irradiation window, and the electron beam will shoot vertically into the surface of the HA block sample. Turn on the electron accelerator, prepare for irradiation, control the energy of the electron accelerator at 1.19-1.21 M...

Embodiment 2

[0046] In this embodiment, the method for improving the degradability of apatite by electron irradiation comprises the following steps:

[0047] a. Put the HA powder into a φ13 tableting mold, use a hydraulic tablet press to apply a pressure of 2t and keep the pressure for half a minute, and get a small disc with a diameter of 13mm and a height of 2mm after demoulding. Subsequently, the wafer was placed in a muffle furnace for heat treatment at 400 °C for 1 h to obtain a HA block sample.

[0048] b. Transfer the HA block sample to a copper irradiated sample box with a height of 2 mm, place it evenly on the sample stage, and fix it with copper glue. The HA block sample is located directly below the irradiation window, and the electron beam will shoot vertically into the surface of the HA block sample. Turn on the electron accelerator, prepare for irradiation, control the energy of the electron accelerator at 1.19-1.21 MeV, the intensity of the electron beam at 5.00-5.70 mA, th...

Embodiment 3

[0051] In this embodiment, the method for improving the degradability of apatite by electron irradiation comprises the following steps:

[0052] a. Put the HA powder into a φ13 tableting mold, use a hydraulic tablet press to apply a pressure of 2t and keep the pressure for half a minute, and get a small disc with a diameter of 13mm and a height of 2mm after demoulding. Subsequently, the wafer was placed in a muffle furnace for heat treatment at 400 °C for 1 h to obtain a HA block sample.

[0053] b. Transfer the HA block sample to a copper irradiated sample box with a height of 2 mm, place it evenly on the sample stage, and fix it with copper glue. The HA block sample is located directly below the irradiation window, and the electron beam will shoot vertically into the surface of the HA block sample. Turn on the electron accelerator, prepare for irradiation, control the energy of the electron accelerator at 1.19-1.21 MeV, the intensity of the electron beam at 5.00-5.70 mA, th...

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Abstract

The invention belongs to the field of biomedical materials and relates to a novel method for improving degradability of apatite biomedical materials by electron irradiation. The ion release rate of hydroxyapatite blocks is improved by means of an electron irradiation method, so that the degradability of the hydroxyapatite is improved. From the perspective of a material microscopic crystal structure, the ion release rate of the hydroxyapatite is remarkably improved by utilizing the electron irradiation method. The method is simple to operate, the degradation rate of the hydroxyapatite can be greatly improved, and the modification effect is remarkable; the degradation rate of the apatite can be flexibly and effectively adjusted by regulating and controlling the irradiation dose of the electrons, so as to meet different actual clinical requirements; heterogeneous ions are not introduced into the method, thereby ensuring the phase purity of the material, and meanwhile, a complex three-dimensional structure does not need to be constructed, and the degradability of the material is improved by optimizing the crystal structure of the material; and according to the method, batch modification of the material can be realized, and large-scale production is realized.

Description

technical field [0001] The invention belongs to the field of biomedical materials and relates to a new method for improving the degradability of apatite biomedical materials by electron irradiation. Background technique [0002] The famous scholar Professor Henchman LL once proposed in the top journal "Science" that the third-generation biomaterials must integrate degradability and biological activity (see the literature Hench LL, Polak JM.Third-generation biomedicalmaterials[J].Science,2002,295 (5557):1014-1017.), and the degradability of biomedical materials is its key research direction. As the main inorganic component of human bone, hydroxyapatite is currently the most widely used calcium phosphate ceramic material, which has excellent biocompatibility and bioactivity, but its degradation rate is extremely slow, and the annual degradation rate after implantation in the human body is low If it is less than 10%, it cannot match the new bone growth rate, which hinders bone...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N23/20058G01N23/2005G01N21/73
CPCG01N21/73G01N23/2005G01N23/20058
Inventor 郭大刚朱卉
Owner XI AN JIAOTONG UNIV
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