A kind of preparation method of starch-based large intestine targeted double-layer probiotic tablet
A probiotic tablet, starch-based technology, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve the problems that the bioavailability needs to be improved, the effect is not significant, and the limitation is limited. , to achieve the effect of effectively maintaining probiotic activity, good colon targeting, and resistance to enzymatic hydrolysis
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0030] (1) Acid hydrolysis: Weigh 100g of waxy cornstarch, add water to adjust the slurry to 50% starch solution, adjust the pH of the starch solution to 2.0 with 0.5M HCI, and stir on a magnetic stirrer at 200rpm for 30min;
[0031] (2) Pre-drying: suction filter the starch slurry in step (1), break the filter residue into small pieces, dry at 45°C for 24 hours, and grind through a 100-mesh sieve;
[0032] (3) Baking at high temperature: Divide the dried starch granules in step (2) into two equal parts, one part is baked at 120°C for 4 hours, and the obtained sample is recorded as outer layer material K1; the other part is baked at 180°C for 5 hours Recorded as core material K2;
[0033] (4) Water washing: wash the above-mentioned baked samples K1 and K2 with water until the pH is neutral;
[0034] (5) Drying and sieving: K1 and K2 after washing were dried at 45°C for 20 hours, crushed and passed through a 100-mesh sieve;
[0035] (6) Probiotic dry powder: Centrifuge the La...
Embodiment 2
[0038] (1) Acid hydrolysis: Weigh 100g of waxy cornstarch, add water to adjust the slurry to a 50% starch solution, adjust the pH of the starch solution to 3.0 with 0.5M HCI, and stir on a magnetic stirrer at 300rpm for 30min;
[0039] (2) Pre-drying: suction filter the starch slurry in step (1), break the filter residue into small pieces, dry at 55°C for 18 hours, and grind through a 100-mesh sieve;
[0040] (3) Baking at high temperature: Divide the starch granules dried in step (2) into two parts, one part is baked at 130°C for 3 hours to obtain the outer layer material; the other part is baked at 190°C for 3 hours to obtain the core layer material ;
[0041] (4) Washing: wash the baked core layer material and outer layer material with water until the pH is neutral;
[0042] (5) Drying and sieving: the washed core material and outer layer material are dried at 45°C for 20 hours, crushed and passed through a 100-mesh sieve;
[0043] (6) Probiotic dry powder: Centrifuge the...
Embodiment 3
[0046] (1) Acid hydrolysis: Weigh 100g of waxy cornstarch, add water to adjust the slurry to a 50% starch solution, adjust the pH of the starch solution to 3.0 with 0.5M HCI, and stir on a magnetic stirrer at 300rpm for 30min;
[0047] (2) Pre-drying: suction filter the starch slurry in step (1), break the filter residue into small pieces, dry at 60°C for 14 hours, and grind through a 100-mesh sieve;
[0048] (3) Baking at high temperature: Divide the dried starch granules in step (2) into two parts, one part is baked at 140°C for 2 hours to obtain the outer layer material; the other part is baked at 195°C for 2 hours to obtain the core layer;
[0049] (4) Washing: washing the baked core layer and outer layer materials with water until the pH is neutral;
[0050] (5) Drying and sieving: the washed core layer and outer layer materials are dried at 45°C for 20 hours, crushed and passed through a 100-mesh sieve;
[0051] (6) Probiotic dry powder: Centrifuge the lactic acid bacte...
PUM
| Property | Measurement | Unit |
|---|---|---|
| water content | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More